UCSF

ZINC03871838

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Substance Information

In ZINC since Heavy atoms Benign functionality
October 4th, 2005 26 No

Popular Name: Calpeptin Calpeptin

Find On: PubMed — Wikipedia — Google

CAS Number: 117591-20-5

Download: MOL2 SDF SMILES Flexibase

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 5.84 8.3 -11.2 2 6 0 85 362.47 12 ↓

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
CAN1-1-E Calpain 1 (cluster #1 Of 2), Eukaryotic Eukaryotes 7 0.44 Binding ≤ 10μM
CATK-1-E Cathepsin K (cluster #1 Of 3), Eukaryotic Eukaryotes 0 0.00 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
CAN1_HUMAN P07384 Calpain 1, Human 1000 0.32 Binding ≤ 1μM
CATK_HUMAN P43235 Cathepsin K, Human 0.11 0.54 Binding ≤ 1μM
CAN1_HUMAN P07384 Calpain 1, Human 1000 0.32 Binding ≤ 10μM
CATK_HUMAN P43235 Cathepsin K, Human 0.11 0.54 Binding ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description Species
Activation of Matrix Metalloproteinases
Collagen degradation
Degradation of the extracellular matrix
MHC class II antigen presentation
Trafficking and processing of endosomal TLR

Analogs ( Draw Identity 99% 90% 80% 70% )

No pre-computed analogs available. Try a structural similarity search.