| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 21st, 2005 | 15 | Yes |
Popular Name: Sib 1893 Sib 1893
Find On: PubMed — Wikipedia — Google
CAS Numbers: 6266-99-5; 7370-21-0 , 7370-21-0
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.20 | 8.43 | -5.98 | 0 | 1 | 0 | 13 | 195.265 | 2 | ↓ |
| Lo Low (pH 4.5-6) | 3.20 | 8.74 | -28.48 | 1 | 1 | 1 | 14 | 196.273 | 2 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRM5-5-E | Metabotropic Glutamate Receptor 5 (cluster #5 Of 5), Eukaryotic | Eukaryotes | 1100 | 0.56 | Binding ≤ 10μM |
| GRM5-3-E | Metabotropic Glutamate Receptor 5 (cluster #3 Of 5), Eukaryotic | Eukaryotes | 3000 | 0.52 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRM5_HUMAN | P41594 | Metabotropic Glutamate Receptor 5, Human | 1100 | 0.56 | Binding ≤ 10μM |
| GRM5_RAT | P31424 | Metabotropic Glutamate Receptor 5, Rat | 1080 | 0.56 | Binding ≤ 10μM |
| GRM5_HUMAN | P41594 | Metabotropic Glutamate Receptor 5, Human | 290 | 0.61 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Class C/3 (Metabotropic glutamate/pheromone receptors) | |
| G alpha (q) signalling events |
