| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 24th, 2005 | 21 | Yes |
Popular Name: 6-methoxy-N-[2-(2-piperidinyl)ethyl]-8-quinolinamine 6-methoxy-N-[2-(2-piperidinyl)et…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 2.71 | 5.79 | -41.27 | 3 | 4 | 1 | 51 | 286.399 | 5 | ↓ |
| Mid Mid (pH 6-8) | 2.71 | 6.28 | -86.46 | 4 | 4 | 2 | 52 | 287.407 | 5 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PHLP2-1-E | PH Domain Leucine-rich Repeat-containing Protein Phosphatase 2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 4000 | 0.36 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PHLP2_HUMAN | Q6ZVD8 | PH Domain Leucine-rich Repeat-containing Protein Phosphatase 2, Human | 4000 | 0.36 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Negative regulation of the PI3K/AKT network |
