| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 25th, 2005 | 34 | Yes |
Popular Name: NVP-ADW742 NVP-ADW742
Find On: PubMed — Wikipedia — Google
CAS Numbers: 475488-23-4 , [475488-23-4]
5-(3-Phenylmethoxyphenyl)-7-[3-(pyrrolidin-1-ylmethyl)cyclobutyl]pyrrolo[2,3-d]pyrimidin-4-amine
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 4.77 | 16.07 | -45.98 | 3 | 6 | 1 | 70 | 454.598 | 7 | ↓ |
| Hi High (pH 8-9.5) | 2.44 | 7.32 | -91.15 | 7 | 7 | 2 | 113 | 458.488 | 5 | ↓ |
| Lo Low (pH 4.5-6) | 4.77 | 16.55 | -86.75 | 4 | 6 | 2 | 72 | 455.606 | 7 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| Target | IGF-1R | Selleck Chemicals |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| IGF1R-1-E | Insulin-like Growth Factor 1 Receptor (cluster #1 Of 2), Eukaryotic | Eukaryotes | 78 | 0.29 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| IGF1R_HUMAN | P08069 | Insulin-like Growth Factor I Receptor, Human | 323 | 0.27 | Binding ≤ 1μM |
| IGF1R_HUMAN | P08069 | Insulin-like Growth Factor I Receptor, Human | 323 | 0.27 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| IRS-related events triggered by IGF1R | |
| SHC-related events triggered by IGF1R | |
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
