Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	1.99	7.22	-33.91	1	2	1	17	203.309	2	↓ MOL2 SDF SMILES Flexibase
Lo Low (pH 4.5-6)	1.99	7.49	-90.84	2	2	2	19	204.317	2	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
ACHA6-3-E	Neuronal Acetylcholine Receptor Subunit Alpha-6 (cluster #3 Of 4), Eukaryotic	Eukaryotes	850	0.57	Binding ≤ 10μM
ACHA7-5-E	Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit (cluster #5 Of 6), Eukaryotic	Eukaryotes	449	0.59	Binding ≤ 10μM
ACHB4-5-E	Neuronal Acetylcholine Receptor Subunit Beta-4 (cluster #5 Of 7), Eukaryotic	Eukaryotes	16	0.73	Binding ≤ 10μM
Q8BGP7-1-E	Neuronal Acetylcholine Receptor Protein Beta-2 Subunit (cluster #1 Of 2), Eukaryotic	Eukaryotes	850	0.57	Binding ≤ 10μM
ACHA3-2-E	Neuronal Acetylcholine Receptor Subunit Alpha-3 (cluster #2 Of 2), Eukaryotic	Eukaryotes	3300	0.51	ADME/T ≤ 10μM
ACHB4-2-E	Neuronal Acetylcholine Receptor Subunit Beta-4 (cluster #2 Of 2), Eukaryotic	Eukaryotes	3300	0.51	ADME/T ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
ACHA7_MOUSE	P49582	Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit, Mouse	449	0.59	Binding ≤ 1μM
Q8BGP7_MOUSE	Q8BGP7	Neuronal Acetylcholine Receptor Protein Beta-2 Subunit, Mouse	16	0.73	Binding ≤ 1μM
ACHA6_MOUSE	Q9R0W9	Neuronal Acetylcholine Receptor Subunit Alpha-6, Mouse	26	0.71	Binding ≤ 1μM
ACHB4_MOUSE	Q8R493	Neuronal Acetylcholine Receptor Subunit Beta-4, Mouse	16	0.73	Binding ≤ 1μM
ACHA7_MOUSE	P49582	Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit, Mouse	449	0.59	Binding ≤ 10μM
Q8BGP7_MOUSE	Q8BGP7	Neuronal Acetylcholine Receptor Protein Beta-2 Subunit, Mouse	16	0.73	Binding ≤ 10μM
ACHA6_MOUSE	Q9R0W9	Neuronal Acetylcholine Receptor Subunit Alpha-6, Mouse	26	0.71	Binding ≤ 10μM
ACHB4_MOUSE	Q8R493	Neuronal Acetylcholine Receptor Subunit Beta-4, Mouse	16	0.73	Binding ≤ 10μM
ACHA3_MOUSE	Q8R4G9	Neuronal Acetylcholine Receptor Subunit Alpha-3, Mouse	3300	0.51	ADME/T ≤ 10μM
ACHB4_MOUSE	Q8R493	Neuronal Acetylcholine Receptor Subunit Beta-4, Mouse	3300	0.51	ADME/T ≤ 10μM

Description	Species
Highly calcium permeable nicotinic acetylcholine receptors	Mus musculus (ACHB4_MOUSE)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	Mus musculus (ACHA7_MOUSE)
Highly sodium permeable acetylcholine nicotinic receptors	Mus musculus (ACHB4_MOUSE)