| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| April 13th, 2010 | 28 | Yes |
Popular Name: [4-(p-tolyl)phenyl]-(1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl)methanone [4-(p-tolyl)phenyl]-(1,3,4,9-tet…
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| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 4.98 | 12.62 | -12.04 | 1 | 3 | 0 | 36 | 366.464 | 2 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| CDK4-2-E | Cyclin-dependent Kinase 4 (cluster #2 Of 3), Eukaryotic | Eukaryotes | 9000 | 0.25 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| CDK4_HUMAN | P11802 | Cyclin-dependent Kinase 4, Human | 9000 | 0.25 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Cyclin D associated events in G1 | |
| Meiotic recombination | |
| Oncogene Induced Senescence | |
| Oxidative Stress Induced Senescence | |
| RMTs methylate histone arginines | |
| Senescence-Associated Secretory Phenotype (SASP) | |
| Transcriptional regulation of white adipocyte differentiation | |
| Ubiquitin-dependent degradation of Cyclin D1 |
