| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| April 13th, 2010 | 22 | Yes |
Popular Name: 2-(2-aminoethylamino)-4-(3-methoxyanilino)pyrimidine-5-carboxamide 2-(2-aminoethylamino)-4-(3-metho…
None
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 0.36 | 1.84 | -58.35 | 7 | 8 | 1 | 130 | 303.346 | 7 | ↓ |
| Hi High (pH 8-9.5) | 0.36 | 1.45 | -12.16 | 6 | 8 | 0 | 128 | 302.338 | 7 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| KSYK-1-E | Tyrosine-protein Kinase SYK (cluster #1 Of 2), Eukaryotic | Eukaryotes | 66 | 0.46 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| KSYK_HUMAN | P43405 | Tyrosine-protein Kinase SYK, Human | 66 | 0.46 | Binding ≤ 1μM |
| KSYK_HUMAN | P43405 | Tyrosine-protein Kinase SYK, Human | 66 | 0.46 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Antigen activates B Cell Receptor (BCR) leading to generation of second messenge | |
| DAP12 signaling | |
| Fc epsilon receptor (FCERI) signaling | |
| FCERI mediated Ca+2 mobilization | |
| FCERI mediated MAPK activation | |
| FCGR activation | |
| GPVI-mediated activation cascade | |
| Integrin alphaIIb beta3 signaling | |
| Interleukin-2 signaling | |
| Regulation of actin dynamics for phagocytic cup formation | |
| Regulation of signaling by CBL | |
| Role of LAT2/NTAL/LAB on calcium mobilization | |
| Role of phospholipids in phagocytosis |
