| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| April 13th, 2010 | 25 | Yes |
Popular Name: 1-[3-butyl-2,4,6-trihydroxy-5-(3-methylbutanoyl)phenyl]-3-methyl-butan-1-one 1-[3-butyl-2,4,6-trihydroxy-5-(3…
None
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 5.21 | 7.75 | -12.11 | 3 | 5 | 0 | 95 | 350.455 | 9 | ↓ |
| Hi High (pH 8-9.5) | 5.21 | 8.37 | -34.97 | 2 | 5 | -1 | 98 | 349.447 | 9 | ↓ |
| Hi High (pH 8-9.5) | 5.21 | 9.44 | -110.56 | 1 | 5 | -2 | 100 | 348.439 | 9 | ↓ |
| Mid Mid (pH 6-8) | 5.21 | 8.43 | -32.22 | 2 | 5 | -1 | 98 | 349.447 | 9 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FFAR1-1-E | Free Fatty Acid Receptor 1 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 970 | 0.34 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FFAR1_HUMAN | O14842 | Free Fatty Acid Receptor 1, Human | 970 | 0.34 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | |
| Free fatty acid receptors | |
| G alpha (q) signalling events | |
| Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | |
| Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polyp |
