Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.19	13.15	-108.4	3	4	2	39	410.65	3	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	7.27	15.48	-8.15	0	3	0	36	414.545	3	↓ MOL2 SDF SMILES Flexibase
Lo Low (pH 4.5-6)	5.19	13.71	-184.59	4	4	3	40	411.658	3	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRD-1-E	Delta Opioid Receptor (cluster #1 Of 3), Eukaryotic	Eukaryotes	4696	0.25	Binding ≤ 10μM
OPRK-1-E	Kappa Opioid Receptor (cluster #1 Of 6), Eukaryotic	Eukaryotes	80	0.33	Binding ≤ 10μM
OPRM-1-E	Mu-type Opioid Receptor (cluster #1 Of 4), Eukaryotic	Eukaryotes	34	0.35	Binding ≤ 10μM
OPRX-1-E	Nociceptin Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	0	0.00	Binding ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRK_HUMAN	P41145	Kappa Opioid Receptor, Human	23.1	0.36	Binding ≤ 1μM
OPRM_HUMAN	P35372	Mu Opioid Receptor, Human	1.052	0.42	Binding ≤ 1μM
OPRX_HUMAN	P41146	Nociceptin Receptor, Human	0.1	0.47	Binding ≤ 1μM
OPRD_HUMAN	P41143	Delta Opioid Receptor, Human	4696	0.25	Binding ≤ 10μM
OPRK_HUMAN	P41145	Kappa Opioid Receptor, Human	23.1	0.36	Binding ≤ 10μM
OPRM_HUMAN	P35372	Mu Opioid Receptor, Human	1.052	0.42	Binding ≤ 10μM
OPRX_HUMAN	P41146	Nociceptin Receptor, Human	0.1	0.47	Binding ≤ 10μM

Description	Species
G alpha (i) signalling events	Homo sapiens (OPRM_HUMAN)
G-protein activation	Homo sapiens (OPRM_HUMAN)
Opioid Signalling	Homo sapiens (OPRM_HUMAN)
Peptide ligand-binding receptors	Homo sapiens (OPRM_HUMAN)