| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| April 13th, 2010 | 26 | Yes |
Popular Name: 1'-(5,6-dichloro-1H-benzimidazol-2-yl)spiro[isobenzofuran-3,4'-piperidine]-1-one 1'-(5,6-dichloro-1H-benzimidazol…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 4.81 | 12.55 | -12.95 | 1 | 5 | 0 | 58 | 388.254 | 1 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| NPY5R-1-E | Neuropeptide Y Receptor Type 5 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 2 | 0.47 | Binding ≤ 10μM |
| NPY5R-1-E | Neuropeptide Y Receptor Type 5 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1 | 0.48 | Functional ≤ 10μM |
| Z50597-1-O | Rattus Norvegicus (cluster #1 Of 1), Other | Other | 4600 | 0.29 | ADME/T ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| NPY5R_HUMAN | Q15761 | Neuropeptide Y Receptor Type 5, Human | 1.6 | 0.47 | Binding ≤ 1μM |
| NPY5R_HUMAN | Q15761 | Neuropeptide Y Receptor Type 5, Human | 1.6 | 0.47 | Binding ≤ 10μM |
| NPY5R_HUMAN | Q15761 | Neuropeptide Y Receptor Type 5, Human | 1.4 | 0.48 | Functional ≤ 10μM |
| Z50597 | Z50597 | Rattus Norvegicus | 2900 | 0.30 | ADME/T ≤ 10μM |
| Description | Species |
|---|---|
| G alpha (i) signalling events | |
| Peptide ligand-binding receptors |
