| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| November 7th, 2005 | 29 | No |
Popular Name: 27-Hydroxycholesterol 27-Hydroxycholesterol
Find On: PubMed — Wikipedia — Google
CAS Numbers: 13095-61-9 , 20380-11-4 , 26259-77-8
(25R)-cholest-5-ene-3beta,26-diol
26-hydroxycholesterol; Cholest-5-ene-3beta,26-diol; Cholest-5-ene-3beta,27-diol
CHEBI:1311; CHEBI:19816; CHEBI:11665
cholest-(25R)-5-en-3beta,26-diol
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 6.35 | -1.65 | -3.71 | 2 | 2 | 0 | 40 | 402.663 | 6 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| UniProt Database Links | CP7B1_HUMAN; CP7B1_MOUSE; CP7B1_RAT | ChEBI |
| Reactome Database Links | REACT_10057; REACT_6881; REACT_9953; REACT_9984; REACT_9994 | ChEBI |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| NR1H3-2-E | LXR-alpha (cluster #2 Of 2), Eukaryotic | Eukaryotes | 250 | 0.32 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| NR1H3_HUMAN | Q13133 | LXR-alpha, Human | 250 | 0.32 | Binding ≤ 1μM |
| NR1H3_HUMAN | Q13133 | LXR-alpha, Human | 250 | 0.32 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Cytosolic sulfonation of small molecules | |
| Endogenous sterols | |
| Synthesis of bile acids and bile salts via 27-hydroxycholesterol |
