Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.48	6.7	-64.03	6	10	1	141	547.632	11	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	3.66	4.33	-42.81	5	10	0	148	546.624	11	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
ACM1-2-E	Muscarinic Acetylcholine Receptor M1 (cluster #2 Of 3), Eukaryotic	Eukaryotes	1000	0.21	Functional ≤ 10μM
ACM1-2-E	Muscarinic Acetylcholine Receptor M1 (cluster #2 Of 3), Eukaryotic	Eukaryotes	1995	0.20	Functional ≤ 10μM
ACM2-1-E	Muscarinic Acetylcholine Receptor M2 (cluster #1 Of 3), Eukaryotic	Eukaryotes	126	0.24	Functional ≤ 10μM
ACM2-1-E	Muscarinic Acetylcholine Receptor M2 (cluster #1 Of 3), Eukaryotic	Eukaryotes	158	0.24	Functional ≤ 10μM
ACM3-2-E	Muscarinic Acetylcholine Receptor M3 (cluster #2 Of 3), Eukaryotic	Eukaryotes	16	0.27	Functional ≤ 10μM
ACM3-2-E	Muscarinic Acetylcholine Receptor M3 (cluster #2 Of 3), Eukaryotic	Eukaryotes	20	0.27	Functional ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
ACM1_HUMAN	P11229	Muscarinic Acetylcholine Receptor M1, Human	1995.26231	0.20	Functional ≤ 10μM
ACM2_HUMAN	P08172	Muscarinic Acetylcholine Receptor M2, Human	158.489319	0.24	Functional ≤ 10μM
ACM3_HUMAN	P20309	Muscarinic Acetylcholine Receptor M3, Human	19.9526231	0.27	Functional ≤ 10μM

Description	Species
Acetylcholine regulates insulin secretion	Homo sapiens (ACM3_HUMAN)
G alpha (i) signalling events	Homo sapiens (ACM2_HUMAN)
G alpha (q) signalling events	Homo sapiens (ACM1_HUMAN)
Muscarinic acetylcholine receptors	Homo sapiens (ACM2_HUMAN)