UCSF

ZINC04324633

Draw Identity 99% 90% 80% 70%

Substance Information

In ZINC since Heavy atoms Benign functionality
November 20th, 2005 25 Yes

Popular Name: GSK264220A GSK264220A

Find On: PubMed — Wikipedia — Google

CAS Number: 685506-42-7

Download: MOL2 SDF SMILES Flexibase

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.82 4.61 -17.16 2 7 0 92 363.439 4 ↓

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
LIPE-1-E Endothelial Lipase (cluster #1 Of 1), Eukaryotic Eukaryotes 130 0.39 Binding ≤ 10μM
LIPL-1-E Lipoprotein Lipase (cluster #1 Of 1), Eukaryotic Eukaryotes 100 0.39 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
LIPE_HUMAN Q9Y5X9 Endothelial Lipase, Human 130 0.39 Binding ≤ 1μM
LIPL_RAT Q06000 Lipoprotein Lipase, Rat 100 0.39 Binding ≤ 1μM
LIPE_HUMAN Q9Y5X9 Endothelial Lipase, Human 130 0.39 Binding ≤ 10μM
LIPL_RAT Q06000 Lipoprotein Lipase, Rat 100 0.39 Binding ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description Species
Chylomicron-mediated lipid transport
Retinoid metabolism and transport
Transcriptional regulation of white adipocyte differentiation

Analogs ( Draw Identity 99% 90% 80% 70% )

No pre-computed analogs available. Try a structural similarity search.