| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| July 28th, 2010 | 25 | No |
Popular Name: SU 6656 SU 6656
None
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.83 | 9.42 | -16.99 | 2 | 5 | 0 | 66 | 355.463 | 3 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| AAPK1-1-E | AMP-activated Protein Kinase, Alpha-1 Subunit (cluster #1 Of 1), Eukaryotic | Eukaryotes | 110 | 0.39 | Binding ≤ 10μM |
| AAPK2-1-E | AMP-activated Protein Kinase, Alpha-2 Subunit (cluster #1 Of 1), Eukaryotic | Eukaryotes | 110 | 0.39 | Binding ≤ 10μM |
| AURKB-1-E | Serine/threonine-protein Kinase Aurora-B (cluster #1 Of 2), Eukaryotic | Eukaryotes | 19 | 0.43 | Binding ≤ 10μM |
| AURKC-1-E | Serine/threonine-protein Kinase Aurora-C (cluster #1 Of 2), Eukaryotic | Eukaryotes | 17 | 0.44 | Binding ≤ 10μM |
| BRSK2-1-E | BR Serine/threonine-protein Kinase 2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 100 | 0.39 | Binding ≤ 10μM |
| LCK-1-E | Tyrosine-protein Kinase LCK (cluster #1 Of 4), Eukaryotic | Eukaryotes | 150 | 0.38 | Binding ≤ 10μM |
| SRC-1-E | Tyrosine-protein Kinase SRC (cluster #1 Of 3), Eukaryotic | Eukaryotes | 100 | 0.39 | Binding ≤ 10μM |
| STK3-1-E | Serine/threonine-protein Kinase MST2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 110 | 0.39 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| AAPK1_RAT | P54645 | AMP-activated Protein Kinase, Alpha-1 Subunit, Rat | 110 | 0.39 | Binding ≤ 1μM |
| AAPK2_RAT | Q09137 | AMP-activated Protein Kinase, Alpha-2 Subunit, Rat | 110 | 0.39 | Binding ≤ 1μM |
| BRSK2_HUMAN | Q8IWQ3 | BR Serine/threonine-protein Kinase 2, Human | 100 | 0.39 | Binding ≤ 1μM |
| AURKB_HUMAN | Q96GD4 | Serine/threonine-protein Kinase Aurora-B, Human | 19 | 0.43 | Binding ≤ 1μM |
| AURKC_HUMAN | Q9UQB9 | Serine/threonine-protein Kinase Aurora-C, Human | 17 | 0.44 | Binding ≤ 1μM |
| STK3_HUMAN | Q13188 | Serine/threonine-protein Kinase MST2, Human | 110 | 0.39 | Binding ≤ 1μM |
| LCK_MOUSE | P06240 | Tyrosine-protein Kinase LCK, Mouse | 150 | 0.38 | Binding ≤ 1μM |
| SRC_CHICK | P00523 | Tyrosine-protein Kinase SRC, Chick | 100 | 0.39 | Binding ≤ 1μM |
| AAPK1_RAT | P54645 | AMP-activated Protein Kinase, Alpha-1 Subunit, Rat | 110 | 0.39 | Binding ≤ 10μM |
| AAPK2_RAT | Q09137 | AMP-activated Protein Kinase, Alpha-2 Subunit, Rat | 110 | 0.39 | Binding ≤ 10μM |
| BRSK2_HUMAN | Q8IWQ3 | BR Serine/threonine-protein Kinase 2, Human | 100 | 0.39 | Binding ≤ 10μM |
| AURKB_HUMAN | Q96GD4 | Serine/threonine-protein Kinase Aurora-B, Human | 19 | 0.43 | Binding ≤ 10μM |
| AURKC_HUMAN | Q9UQB9 | Serine/threonine-protein Kinase Aurora-C, Human | 17 | 0.44 | Binding ≤ 10μM |
| STK3_HUMAN | Q13188 | Serine/threonine-protein Kinase MST2, Human | 110 | 0.39 | Binding ≤ 10μM |
| LCK_MOUSE | P06240 | Tyrosine-protein Kinase LCK, Mouse | 150 | 0.38 | Binding ≤ 10μM |
| SRC_CHICK | P00523 | Tyrosine-protein Kinase SRC, Chick | 100 | 0.39 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| ADP signalling through P2Y purinoceptor 1 | |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins | |
| c-src mediated regulation of Cx43 function and closure of gap junctions | |
| CD28 co-stimulation | |
| CD28 dependent PI3K/Akt signaling | |
| CD28 dependent Vav1 pathway | |
| Constitutive PI3K/AKT Signaling in Cancer | |
| CTLA4 inhibitory signaling | |
| DAP12 signaling | |
| DCC mediated attractive signaling | |
| Downstream signal transduction | |
| Downstream TCR signaling | |
| DSCAM interactions | |
| EPH-ephrin mediated repulsion of cells | |
| EPH-Ephrin signaling | |
| EPHA-mediated growth cone collapse | |
| EPHB-mediated forward signaling | |
| Ephrin signaling | |
| GAB1 signalosome | |
| Generation of second messenger molecules | |
| GP1b-IX-V activation signalling | |
| GPVI-mediated activation cascade | |
| GRB2:SOS provides linkage to MAPK signaling for Integrins | |
| Integrin alphaIIb beta3 signaling | |
| Interleukin-2 signaling | |
| Mitotic Prometaphase | |
| NCAM signaling for neurite out-growth | |
| Netrin mediated repulsion signals | |
| p130Cas linkage to MAPK signaling for integrins | |
| p38MAPK events | |
| PD-1 signaling | |
| Phosphorylation of CD3 and TCR zeta chains | |
| PIP3 activates AKT signaling | |
| Regulation of AMPK activity via LKB1 | |
| Regulation of KIT signaling | |
| Regulation of Rheb GTPase activity by AMPK | |
| Resolution of Sister Chromatid Cohesion | |
| Separation of Sister Chromatids | |
| Signal regulatory protein (SIRP) family interactions | |
| Signaling by EGFR | |
| Signaling by ERBB2 | |
| Signaling by Hippo | |
| Signaling by SCF-KIT | |
| Thrombin signalling through proteinase activated receptors (PARs) | |
| Translocation of ZAP-70 to Immunological synapse | |
| VEGFA-VEGFR2 Pathway | |
| VEGFR2 mediated cell proliferation |
No pre-computed analogs available. Try a structural similarity search.