| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| July 31st, 2010 | 38 | No |
Popular Name: 8-indan-5-yl-N-methoxy-5-oxo-2-[4-(4-piperidyl)anilino]pyrido[2,3-d]pyrimidine-6-carboxamide 8-indan-5-yl-N-methoxy-5-oxo-2-[…
None
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 2.76 | 15.53 | -52.31 | 4 | 9 | 1 | 115 | 511.606 | 6 | ↓ |
| Hi High (pH 8-9.5) | 2.83 | 14.05 | -91.39 | 3 | 9 | 0 | 121 | 510.598 | 6 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| CSF1R-1-E | Macrophage Colony-stimulating Factor 1 Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1 | 0.33 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| CSF1R_HUMAN | P07333 | Macrophage Colony Stimulating Factor Receptor, Human | 0.5 | 0.34 | Binding ≤ 1μM |
| CSF1R_MOUSE | P09581 | Macrophage Colony-stimulating Factor 1 Receptor, Mouse | 1.1 | 0.33 | Binding ≤ 1μM |
| CSF1R_HUMAN | P07333 | Macrophage Colony Stimulating Factor Receptor, Human | 0.5 | 0.34 | Binding ≤ 10μM |
| CSF1R_MOUSE | P09581 | Macrophage Colony-stimulating Factor 1 Receptor, Mouse | 1.1 | 0.33 | Binding ≤ 10μM |
