Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	1.03	3.3	-104.48	8	12	2	166	688.822	5	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	1.03	1.06	-59.53	7	12	1	165	687.814	5	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	1.03	-1.18	-19.08	6	12	0	164	686.806	5	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRD-1-E	Delta Opioid Receptor (cluster #1 Of 3), Eukaryotic	Eukaryotes	200	0.19	Binding ≤ 10μM
OPRK-1-E	Kappa Opioid Receptor (cluster #1 Of 6), Eukaryotic	Eukaryotes	180	0.19	Binding ≤ 10μM
OPRM-1-E	Mu-type Opioid Receptor (cluster #1 Of 4), Eukaryotic	Eukaryotes	23	0.21	Binding ≤ 10μM
OPRK-1-E	Kappa Opioid Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	16	0.22	Functional ≤ 10μM
OPRM-1-E	Mu Opioid Receptor (cluster #1 Of 2), Eukaryotic	Eukaryotes	16	0.22	Functional ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRD_HUMAN	P41143	Delta Opioid Receptor, Human	200	0.19	Binding ≤ 1μM
OPRK_HUMAN	P41145	Kappa Opioid Receptor, Human	180	0.19	Binding ≤ 1μM
OPRM_HUMAN	P35372	Mu Opioid Receptor, Human	23	0.21	Binding ≤ 1μM
OPRD_HUMAN	P41143	Delta Opioid Receptor, Human	200	0.19	Binding ≤ 10μM
OPRK_HUMAN	P41145	Kappa Opioid Receptor, Human	180	0.19	Binding ≤ 10μM
OPRM_HUMAN	P35372	Mu Opioid Receptor, Human	23	0.21	Binding ≤ 10μM
OPRK_HUMAN	P41145	Kappa Opioid Receptor, Human	15.7	0.22	Functional ≤ 10μM
OPRM_HUMAN	P35372	Mu Opioid Receptor, Human	15.7	0.22	Functional ≤ 10μM

Description	Species
G alpha (i) signalling events	Homo sapiens (OPRM_HUMAN)
G-protein activation	Homo sapiens (OPRM_HUMAN)
Opioid Signalling	Homo sapiens (OPRM_HUMAN)
Peptide ligand-binding receptors	Homo sapiens (OPRM_HUMAN)