| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| February 1st, 2006 | 20 | Yes |
Popular Name: Albendazole sulfone Albendazole sulfone
Find On: PubMed — Wikipedia — Google
CAS Number: 75184-71-3
75184-71-3; Albendazole sulfone; C16626
Methyl 5-n-propylsulfonyl-2-benzimidazolecarbamate
[5-(Propane-1-sulfonyl)-1H-benzoimidazol-2-yl]-carbamic acid methyl ester
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 1.36 | 2.01 | -15.33 | 2 | 7 | 0 | 104 | 297.336 | 4 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| mechanism | . | ZereneX Building Blocks |
| Melting_Point | 290-292? | Alfa-Aesar |
| Melting_Point | 290-292° | Alfa-Aesar |
| mechanism | Also has been shown to inhibit the enzyme fumarate reductase, which is helminth-specific. | IBScreen Bioactives |
| biological_use | Anthelmintic | IBScreen Bioactives IBScreen Bioactives |
| mechanism | Causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, | IBScreen Bioactives |
| mechanism | Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP), | IBScreen Bioactives |
| mechanism | Due to diminished energy production, the parasite is immobilized and eventually dies. | IBScreen Bioactives |
| biological_use | Investigated for treatment of chronic stronglyoidiasis, and for microsporidiosis in AIDS patients | IBScreen Bioactives |
| mechanism | The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores. | IBScreen Bioactives |
| mechanism | This action may be considered secondary to the effect | IBScreen Bioactives |
| mechanism | thus inhibiting its polymerization or assembly into microtubules. | IBScreen Bioactives |
| mechanism | which is the energy required for the survival of the helminth. | IBScreen Bioactives |
No pre-computed analogs available. Try a structural similarity search.