| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| February 9th, 2011 | 32 | Yes |
Popular Name: N-[2-(1-oxo-4-phenyl-2,4,8-triazaspiro[4.5]decan-8-yl)ethyl]-4-(trifluoromethyl)benzamide N-[2-(1-oxo-4-phenyl-2,4,8-triaz…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.20 | 8.34 | -48.57 | 3 | 6 | 1 | 66 | 447.481 | 6 | ↓ |
| Hi High (pH 8-9.5) | 3.20 | 6.09 | -11.81 | 2 | 6 | 0 | 65 | 446.473 | 6 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PLD2-1-E | Phospholipase D2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 4300 | 0.23 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PLD2_HUMAN | O14939 | Phospholipase D2, Human | 4300 | 0.23 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Role of phospholipids in phagocytosis | |
| Synthesis of PA | |
| Synthesis of PG |
![1,3,8-triazaspiro[4.5]decan-4-one](http://zinc12.docking.org/img/rings/14399.gif)
![N-[2-(1-keto-4-phenyl-2,4,8-triazaspiro[4.5]decan-8-yl)ethyl]benzamide](http://zinc12.docking.org/img/rings/192337.gif)
