| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| February 19th, 2006 | 22 | No |
Popular Name: 7255-94-9; N,N'-di(1H-indazol-6-yl)thiourea; nsc74429 7255-94-9; N,N'-di(1H-indazol-6-…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 1.74 | 5.1 | -16.92 | 4 | 6 | 0 | 81 | 308.37 | 4 | ↓ |
| Mid Mid (pH 6-8) | 1.74 | 5.1 | -22.01 | 4 | 6 | 0 | 81 | 308.37 | 4 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PHLP2-1-E | PH Domain Leucine-rich Repeat-containing Protein Phosphatase 2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 5000 | 0.34 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PHLP2_HUMAN | Q6ZVD8 | PH Domain Leucine-rich Repeat-containing Protein Phosphatase 2, Human | 5000 | 0.34 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Negative regulation of the PI3K/AKT network |
