UCSF

ZINC60094177

Substance Information

In ZINC since Heavy atoms Benign functionality
March 14th, 2011 32 No

Other Names:

({[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy(hydroxy)phosphoryl}oxy(hydroxy)phosphoryl)oxyphosphonic acid

5'-GTP; BRN 1201437; EINECS 201-647-3; GTP; Guanosine 5'-(tetrahydrogen triphosphate); Guanosine 5'-triphosphate; Guanosine 5'-triphosphoric acid; Guanosine triphosphate; LS-73963

5'-GTP; GTG; GTP; Guanosine 5'-(tetrahydrogen triphosphate); Guanosine 5'-triphosphate; Guanosine 5'-triphosphorate; Guanosine 5'-triphosphoric acid; Guanosine mono(tetrahydrogen triphosphate) (ester); Guanosine Triphosphate; H4gtp

5'-GTP; GTG; GTP; Guanosine 5'-(tetrahydrogen triphosphate); Guanosine 5'-triphosphate; Guanosine 5'-triphosphorate; Guanosine 5'-triphosphoric acid; Guanosine Triphosphate

5'-GTP; GTG; GTP; Guanosine 5'-(tetrahydrogen triphosphate); Guanosine 5'-triphosphate; Guanosine 5'-triphosphorate; Guanosine 5'-triphosphoric acid; Guanosine Triphosphate; Guanosine mono(tetrahydrogen triphosphate) (ester); H4gtp

5'-GTP; H4gtp; guanosine 5'-triphosphoric acid; guanosine triphosphate

5'-GTP;GTG;GTP;Guanosine 5'-(tetrahydrogen triphosphate);Guanosine 5'-triphosphate;Guanosine 5'-triphosphorate;Guanosine 5'-triphosphoric acid;Guanosine mono(tetrahydrogen triphosphate) (ester);Guanosine Triphosphate;H4gtp

5'-GTP;GTG;GTP;Guanosine 5'-(tetrahydrogen triphosphate);Guanosine 5'-triphosphate;Guanosine 5'-triphosphorate;Guanosine 5'-triphosphoric acid;Guanosine Triphosphate;Guanosine mono(tetrahydrogen triphosphate) (ester);H4gtp

86-01-1; C00044; GTP; Guanosine 5'-triphosphate

86-01-1; GTP; guanosine 5'-triphosphate; guanosine-triphosphate; guanylyl imidodiphosphate

CHEBI:42934; CHEBI:13342; CHEBI:5234; CHEBI:24451

GTP

GTP trianion; GTP(3-)

GTP(3-)

GTP(4-)

GTP; gtp

Guanosine 5'-triphosphate sodium salt

Guanosine 5'-triphosphate, disodium salt hydrate, 90%, for biochemistry

Guanosine 5-triphosphate disodium salt

MFCD03410297

Download: MOL2 SDF SMILES Flexibase

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -4.22 -7.52 -180.6 6 19 -3 308 520.157 8
Mid Mid (pH 6-8) -4.53 -4.25 -237.08 6 19 -3 308 520.157 8

Vendor Notes

Note Type Comments Provided By
UniProt Database Links 128UP_DROME; A4_BOVIN; A4_CANFA; A4_MACMU; A4_RABIT; A4_SHEEP; A4_TAKRU; A4_TETFL; A4_URSMA; AB1IP_HUMAN; ACAP1_BOVIN; ACAP1_HUMAN; ACKA_SALTY; ACKA_THEMA; ACSM1_BOVIN; ACSM1_HUMAN; ACSM1_MOUSE; ACTH_THEAC; ACTH_THEVO; ADOK_MYCTA; ADRA_ECOLI; AFI1_YEAST ChEBI
Mp [°C] 180 Acros Organics
PUBCHEM_PATENT_ID EP0073628A1; EP0147713A2; EP0237045A2; EP0237045B1; EP0285343A2; EP0285343B1; EP0288901A2; EP0305093A1; EP0322677A2; EP0322677B1; EP0324258A1; EP0324258B1; EP0332435A2; EP0332435B2; EP0335654A2; EP0344024A1; EP0344024B1; EP0364266A2; EP0389299A1; EP040537 IBM Patent Data
Patent Database Links EP1152008; EP1279729; EP1580556; EP1586325; EP1780268; EP1870465; EP1952812; US2003153523; US2006008869; US2007178090; US2007197438; US2007224208; US2007225203; US2007232591; WO2006089076; WO2007106349; WO2007120702; WO2007130604 ChEBI
Reactome Database Links REACT_10004; REACT_10011; REACT_10098; REACT_10108; REACT_10126; REACT_1060; REACT_1082; REACT_1094; REACT_11099; REACT_111091; REACT_111095; REACT_11111; REACT_111126; REACT_111143; REACT_111195; REACT_11243; REACT_1138; REACT_115675; REACT_115771; REACT ChEBI
S phrase S24/25: Avoid contact with skin and eyes. Acros Organics

Activity (Go SEA)

Direct Reactome Annotations (via ChEBI)

Description Species
Acetylcholine regulates insulin secretion
Activation of Rac
Activation of RAS in B cells
Activation of the phototransduction cascade
Adenylate cyclase activating pathway
Adenylate cyclase inhibitory pathway
ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 12
Adrenaline,noradrenaline inhibits insulin secretion
Amino acid synthesis and interconversion (transamination)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
ARMS-mediated activation
Axonal growth inhibition (RHOA activation)
Ca2+ pathway
CD28 dependent Vav1 pathway
CDO in myogenesis
Citric acid cycle (TCA cycle)
Clathrin derived vesicle budding
COPI Mediated Transport
COPII (Coat Protein 2) Mediated Vesicle Transport
CREB phosphorylation through the activation of Ras
DAP12 signaling
DCC mediated attractive signaling
De novo synthesis of AMP
DNA replication initiation
Downstream signal transduction
DSCAM interactions
EGFR downregulation
EGFR Transactivation by Gastrin
EPH-ephrin mediated repulsion of cells
EPHA-mediated growth cone collapse
EPHB-mediated forward signaling
Ephrin signaling
Eukaryotic Translation Elongation
Eukaryotic Translation Termination
Factors involved in megakaryocyte development and platelet production
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
FCERI mediated MAPK activation
Formation of the Early Elongation Complex
Formation of the ternary complex, and subsequently, the 43S complex
Formation of tubulin folding intermediates by CCT/TriC
Frs2-mediated activation
FRS2-mediated cascade
G alpha (12/13) signalling events
G alpha (i) signalling events
G alpha (q) signalling events
G alpha (s) signalling events
G alpha (z) signalling events
G-protein activation
Gap junction assembly
Glucagon signaling in metabolic regulation
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Gluconeogenesis
Golgi Associated Vesicle Biogenesis
Golgi Cisternae Pericentriolar Stack Reorganization
GPVI-mediated activation cascade
GRB2 events in EGFR signaling
GRB2 events in ERBB2 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
GTP hydrolysis and joining of the 60S ribosomal subunit
Inactivation of Cdc42 and Rac
Inactivation, recovery and regulation of the phototransduction cascade
Integrin alphaIIb beta3 signaling
Interleukin receptor SHC signaling
Kinesins
L13a-mediated translational silencing of Ceruloplasmin expression
Lysosome Vesicle Biogenesis
MEK activation
MHC class II antigen presentation
MicroRNA (miRNA) biogenesis
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
Mitotic Prometaphase
Molybdenum cofactor biosynthesis
mRNA Capping
mTOR signalling
NCAM signaling for neurite out-growth
NEP/NS2 Interacts with the Cellular Export Machinery
Nitric oxide stimulates guanylate cyclase
NRAGE signals death through JNK
Nuclear import of Rev protein
p130Cas linkage to MAPK signaling for integrins
p38MAPK events
PCP/CE pathway
Peptide chain elongation
PKA activation in glucagon signalling
Platelet degranulation
Platelet sensitization by LDL
PLC beta mediated events
Post-chaperonin tubulin folding pathway
Prostacyclin signalling through prostacyclin receptor
Purine ribonucleoside monophosphate biosynthesis
RAF activation
RAF phosphorylates MEK
Rap1 signalling
Ras activation uopn Ca2+ infux through NMDA receptor
Recruitment of NuMA to mitotic centrosomes
Recycling of eIF2:GDP
Recycling pathway of L1
Regulation of actin dynamics for phagocytic cup formation
Regulation of cholesterol biosynthesis by SREBP (SREBF)
Regulation of insulin secretion
Regulation of PLK1 Activity at G2/M Transition
Regulation of Rheb GTPase activity by AMPK
Release of eIF4E
Resolution of Sister Chromatid Cohesion
Retrograde neurotrophin signalling
Rev-mediated nuclear export of HIV RNA
Rho GTPase cycle
Ribosomal scanning and start codon recognition
RNA Polymerase I Chain Elongation
RNA Polymerase II Pre-transcription Events
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase III Chain Elongation
S6K1-mediated signalling
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Sema4D induced cell migration and growth-cone collapse
Sema4D mediated inhibition of cell attachment and migration
Separation of Sister Chromatids
SHC-mediated cascade
SHC-mediated signalling
SHC1 events in EGFR signaling
SHC1 events in ERBB2 signaling
SHC1 events in ERBB4 signaling
Signal transduction by L1
Signaling by constitutively active EGFR
Signaling by FGFR mutants
Signaling by SCF-KIT
Signalling to p38 via RIT and RIN
Signalling to RAS
SOS-mediated signalling
STING mediated induction of host immune responses
Sulfate assimilation
Synthesis and interconversion of nucleotide di- and triphosphates
Synthesis of GDP-mannose
Synthesis of PIPs at the Golgi membrane
Telomere C-strand synthesis initiation
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
The proton buffering model
The tricarboxylic acid cycle
Thrombin signalling through proteinase activated receptors (PARs)
Thromboxane signalling through TP receptor
Tie2 Signaling
Translation initiation complex formation
Translocation of GLUT4 to the plasma membrane
Vasopressin regulates renal water homeostasis via Aquaporins
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation
VEGFR2 mediated vascular permeability

Analogs ( Draw Identity 99% 90% 80% 70% )

No pre-computed analogs available. Try a structural similarity search.