Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.48	10.73	-33.69	4	5	1	78	412.513	6	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	5.48	10.34	-15.28	3	5	0	77	411.505	6	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	6.22	7.85	-16.18	4	8	0	134	600.793	9	↓ MOL2 SDF SMILES Flexibase

Note Type	Comments	Provided By
Target	Opioid Receptor	Selleck Chemicals

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRD-1-E	Delta Opioid Receptor (cluster #1 Of 3), Eukaryotic	Eukaryotes	8647	0.23	Binding ≤ 10μM
OPRK-1-E	Kappa Opioid Receptor (cluster #1 Of 6), Eukaryotic	Eukaryotes	7512	0.23	Binding ≤ 10μM
OPRM-1-E	Mu-type Opioid Receptor (cluster #1 Of 4), Eukaryotic	Eukaryotes	1507	0.26	Binding ≤ 10μM
OPRX-1-E	Nociceptin Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	8	0.37	Binding ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRM_HUMAN	P35372	Mu Opioid Receptor, Human	102	0.32	Binding ≤ 1μM
OPRX_HUMAN	P41146	Nociceptin Receptor, Human	30	0.34	Binding ≤ 1μM
OPRD_HUMAN	P41143	Delta Opioid Receptor, Human	8647	0.23	Binding ≤ 10μM
OPRK_HUMAN	P41145	Kappa Opioid Receptor, Human	1057	0.27	Binding ≤ 10μM
OPRM_HUMAN	P35372	Mu Opioid Receptor, Human	102	0.32	Binding ≤ 10μM
OPRX_HUMAN	P41146	Nociceptin Receptor, Human	30	0.34	Binding ≤ 10μM

Description	Species
G alpha (i) signalling events	Homo sapiens (OPRM_HUMAN)
G-protein activation	Homo sapiens (OPRM_HUMAN)
Opioid Signalling	Homo sapiens (OPRM_HUMAN)
Peptide ligand-binding receptors	Homo sapiens (OPRM_HUMAN)