UCSF

ZINC06719711

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Substance Information

In ZINC since Heavy atoms Benign functionality
April 20th, 2006 22 Yes

Popular Name: 4-[4-(2-methoxyphenyl)thiazol-2-yl]-2-propyl-pyridine 4-[4-(2-methoxyphenyl)thiazol-2-…

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Download: MOL2 SDF SMILES Flexibase

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 4.69 0.64 -8.97 0 3 0 35 310.422 5 ↓

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
SRBP2-1-E Sterol Regulatory Element-binding Protein 2 (cluster #1 Of 2), Eukaryotic Eukaryotes 3200 0.35 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
SRBP2_HUMAN Q12772 Sterol Regulatory Element-binding Protein 2, Human 3200 0.35 Binding ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description Species
Activation of gene expression by SREBF (SREBP)
PPARA activates gene expression
Regulation of cholesterol biosynthesis by SREBP (SREBF)
Transcriptional regulation of white adipocyte differentiation

Analogs ( Draw Identity 99% 90% 80% 70% )

No pre-computed analogs available. Try a structural similarity search.