| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| July 26th, 2004 | 25 | Yes |
Popular Name: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine N-(4-Ethoxyphenyl)-4-(2-methylim…
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CAS Number: 315703-52-7
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 4.55 | -0.15 | -13.08 | 1 | 5 | 0 | 51 | 350.447 | 5 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| SHH-2-E | Sonic Hedgehog Protein (cluster #2 Of 2), Eukaryotic | Eukaryotes | 30 | 0.42 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| SHH_MOUSE | Q62226 | Sonic Hedgehog Protein, Mouse | 30 | 0.42 | Binding ≤ 1μM |
| SHH_MOUSE | Q62226 | Sonic Hedgehog Protein, Mouse | 30 | 0.42 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Class B/2 (Secretin family receptors) | |
| Hedgehog ligand biogenesis | |
| Hh ligand biogenesis disease | |
| Release of Hh-Np from the secreting cell |
