UCSF

ZINC08214428

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Substance Information

In ZINC since Heavy atoms Benign functionality
July 4th, 2006 24 No

Popular Name: 1,2-Dioctanoyl-sn-glycerol 1,2-Dioctanoyl-sn-glycerol

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CAS Number: 60514-48-9

Download: MOL2 SDF SMILES Flexibase

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 5.69 2.62 -8.77 1 5 0 72 344.492 18 ↓

Vendor Notes

Note Type Comments Provided By
UniProt Database Links DGK2_ARATH; DGKA_DICDI ChEBI

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
KPCG-1-E Protein Kinase C Gamma (cluster #1 Of 4), Eukaryotic Eukaryotes 2930 0.32 Binding ≤ 10μM
KPCL-1-E Protein Kinase C Eta (cluster #1 Of 4), Eukaryotic Eukaryotes 15 0.46 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
KPCL_MOUSE P23298 Protein Kinase C Eta, Mouse 14.5 0.46 Binding ≤ 1μM
KPCL_MOUSE P23298 Protein Kinase C Eta, Mouse 14.5 0.46 Binding ≤ 10μM
KPCG_RAT P63319 Protein Kinase C Gamma, Rat 2930 0.32 Binding ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description Species
Calmodulin induced events
Disinhibition of SNARE formation
Effects of PIP2 hydrolysis
G alpha (z) signalling events
Response to elevated platelet cytosolic Ca2+
Trafficking of GluR2-containing AMPA receptors
WNT5A-dependent internalization of FZD4

Analogs ( Draw Identity 99% 90% 80% 70% )