UCSF

ZINC96942201

Draw Identity 99% 90% 80% 70%

Substance Information

In ZINC since Heavy atoms Benign functionality
June 9th, 2014 0 Yes

Popular Name: Felodipine Felodipine

Find On: PubMed — Wikipedia — Google

CAS Numbers: 105618-03-9 , 119945-59-4 , 72509-76-3 , [72509-76-3]

Download: MOL2 SDF SMILES Flexibase

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 4.80 10.59 -13.93 1 5 0 65 384.259 6 ↓

Vendor Notes

Note Type Comments Provided By
purity 9.500000000000000e+001 Enamine Building Blocks Enamine Building Blocks
Purity >99% Fluorochem
Indications Antihypertensive KeyOrganics Bioactives
biological_use Antihypertensive agent IBScreen Bioactives IBScreen Bioactives
mechanism Blocks voltage-dependent calcium currents in vascular smooth muscle and cultured rabbit atrial cells, and blocks potassium-induced contracture of the rat portal vein IBScreen Bioactives
mechanism By blocking the calcium channels, inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes and IBScreen Bioactives
mechanism Calcium channel blocker IBScreen Bioactives IBScreen Bioactives
Target NULL Selleck Chemicals
mechanism results in a decrease of peripheral vascular resistance. IBScreen Bioactives
mechanism Reversibly competes with nitrendipine and other calcium channel blockers for dihydropyridine binding sites IBScreen Bioactives
biological_use Used to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina IBScreen Bioactives
biological_use Vasodilator IBScreen Bioactives

Activity (Go SEA)

Analogs ( Draw Identity 99% 90% 80% 70% )

No pre-computed analogs available. Try a structural similarity search.