ZINC 12

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Swissprot:: FGF2_HUMAN
Stitch:: FGF2_HUMAN
UniProt:: P09038
ChEMBL:: CHEMBL3107
Reactome:: REACT_120863; REACT_147727; REACT_9400; REACT_9515; REACT_9413; REACT_9510; REACT_9452; REACT_21247; REACT_111184; REACT_163874; REACT_21310; REACT_21270; REACT_976; REACT_75829; REACT_200759; REACT_21374; REACT_121153; REACT_121337; REACT_121398; REACT_121249; REACT_163942
PDB:: 1BAS (DOCK); 1BFB (DOCK); 1BFC (DOCK); 1BFF (DOCK); 1BFG (DOCK); 1BLA (DOCK); 1BLD (DOCK); 1CVS (DOCK); 1EV2 (DOCK); 1FGA (DOCK); 1FQ9 (DOCK); 1II4 (DOCK); 1IIL (DOCK); 2BFH (DOCK); 2FGF (DOCK); 4FGF (DOCK); FGF2

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	4	0	0	0
Binding ≤ 1μM	4	0	0	0

Reactome ID	Description	Species
REACT_120863	Activated point mutants of FGFR2	Homo sapiens
REACT_147727	Constitutive PI3K/AKT Signaling in Cancer	Homo sapiens
REACT_9400	FGFR1b ligand binding and activation	Homo sapiens
REACT_9515	FGFR1c ligand binding and activation	Homo sapiens
REACT_9413	FGFR2c ligand binding and activation	Homo sapiens
REACT_9510	FGFR3c ligand binding and activation	Homo sapiens
REACT_9452	FGFR4 ligand binding and activation	Homo sapiens
REACT_21247	FRS2-mediated cascade	Homo sapiens
REACT_111184	Negative regulation of FGFR signaling	Homo sapiens
REACT_163874	Non-integrin membrane-ECM interactions	Homo sapiens
REACT_21310	Phospholipase C-mediated cascade	Homo sapiens
REACT_21270	PI-3K cascade	Homo sapiens
REACT_976	PI3K Cascade	Homo sapiens
REACT_75829	PIP3 activates AKT signaling	Homo sapiens
REACT_200759	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	Homo sapiens
REACT_21374	SHC-mediated cascade	Homo sapiens
REACT_121153	Signaling by activated point mutants of FGFR1	Homo sapiens
REACT_121337	Signaling by activated point mutants of FGFR3	Homo sapiens
REACT_121398	Signaling by FGFR mutants	Homo sapiens
REACT_121249	Signaling by FGFR3 mutants	Homo sapiens
REACT_163942	Syndecan interactions	Homo sapiens

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
FGF1_HUMAN	P05230	CHEMBL2120	Acidic Fibroblast Growth Factor, Human	0	0	0	0
FGFR1_HUMAN	P11362	CHEMBL3650	Fibroblast Growth Factor Receptor 1, Human	568	60	16	28
FGFR2_HUMAN	P21802	CHEMBL4142	Fibroblast Growth Factor Receptor 2, Human	111	24	6	11
FGFR3_HUMAN	P22607	CHEMBL2742	Fibroblast Growth Factor Receptor 3, Human	76	23	6	10
FGFR4_HUMAN	P22455	CHEMBL3973	Fibroblast Growth Factor Receptor 4, Human	62	13	3	6