| Annotation Type | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|
| Binding ≤ 10μM | 231 | 1 | 1 | 2 |
| Binding ≤ 1μM | 172 | 1 | 1 | 2 |
| Functional ≤ 10μM | 10 | 0 | 0 | 0 |
| Reactome ID | Description | Species |
|---|---|---|
| REACT_200731 | deactivation of the beta-catenin transactivating complex | Homo sapiens |
| REACT_2190 | SMAC binds to IAPs | Homo sapiens |
| REACT_1767 | SMAC-mediated dissociation of IAP:caspase complexes | Homo sapiens |
| Code | Description | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|---|
| XIAP-1-E | Inhibitor Of Apoptosis Protein 3 (cluster #1 Of 2), Eukaryotic | 226 | 0 | 0 | 2 |
| XIAP-2-E | Inhibitor Of Apoptosis Protein 3 (cluster #2 Of 2), Eukaryotic | 7 | 1 | 1 | 0 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| BIRC2_HUMAN | Q13490 | CHEMBL5462 | Baculoviral IAP Repeat-containing Protein 2, Human | 19 |
| BIRC3_HUMAN | Q13489 | CHEMBL5335 | Baculoviral IAP Repeat-containing Protein 3, Human | 17 |
| Z81252 | Z81252 | CHEMBL400 | MDA-MB-231 (Breast Adenocarcinoma Cells) | 8 |
| Z80493 | Z80493 | CHEMBL614925 | SK-OV-3 (Ovarian Carcinoma Cells) | 5 |
| BIRC8_HUMAN | Q96P09 | CHEMBL5851 | Baculoviral IAP Repeat-containing Protein 8, Human | 2 |