UCSF
ZINC Item Suppliers, Protomers, & Similar Substances

Analogs

13343480
13343480
33378302
33378302
40006440
40006440
1238447
1238447

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Popular Name: 3-[(5E)-5-[(3,4-dibenzyloxyphenyl)methylene]-4-oxo-2-thioxo-thiazolidin-3-yl]propanoic 3-[(5E)-5-[(3,4-dibenzyloxypheny…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
ATS5-1-E ADAMTS5 (cluster #1 Of 1), Eukaryotic Eukaryotes 5300 0.21 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 4.25 16.06 -57.05 0 6 -1 81 504.609 10 ↓

Analogs

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Popular Name: ADAMTS-5 inhibitor ADAMTS-5 inhibitor

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
ATS5-1-E ADAMTS5 (cluster #1 Of 1), Eukaryotic Eukaryotes 1100 0.31 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 4.79 7.97 -45.31 0 4 -1 54 448.924 5 ↓
Lo Low (pH 4.5-6) 4.33 9.09 -13.22 1 4 0 51 449.932 5 ↓

Analogs

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Popular Name: (2R)-5-(p-tolyl)spiro[3H-1,3,4-thiadiazole-2,3'-indoline]-2'-one (2R)-5-(p-tolyl)spiro[3H-1,3,4-t…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
ATS5-1-E ADAMTS5 (cluster #1 Of 1), Eukaryotic Eukaryotes 3700 0.36 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.06 -3.96 -10.4 2 4 0 53 295.367 1 ↓

Analogs

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Popular Name: (2S)-5-(p-tolyl)spiro[3H-1,3,4-thiadiazole-2,3'-indoline]-2'-one (2S)-5-(p-tolyl)spiro[3H-1,3,4-t…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
ATS5-1-E ADAMTS5 (cluster #1 Of 1), Eukaryotic Eukaryotes 3700 0.36 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.06 -3.96 -10.35 2 4 0 53 295.367 1 ↓

Analogs

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Popular Name: (2R)-5'-ethyl-5-(p-tolyl)spiro[3H-1,3,4-thiadiazole-2,3'-indoline]-2'-one (2R)-5'-ethyl-5-(p-tolyl)spiro[3…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
ATS5-1-E ADAMTS5 (cluster #1 Of 1), Eukaryotic Eukaryotes 1900 0.35 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.95 6.99 -9.9 2 4 0 53 323.421 2 ↓

Analogs

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Popular Name: (2S)-5'-ethyl-5-(p-tolyl)spiro[3H-1,3,4-thiadiazole-2,3'-indoline]-2'-one (2S)-5'-ethyl-5-(p-tolyl)spiro[3…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
ATS5-1-E ADAMTS5 (cluster #1 Of 1), Eukaryotic Eukaryotes 1900 0.35 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.95 6.99 -9.91 2 4 0 53 323.421 2 ↓

Analogs

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Popular Name: N-[(3R,4R)-3-(hydroxycarbamoyl)tetrahydropyran-4-yl]-4-[[2-(trifluoromethyl)benzimidazol-1-yl]methyl N-[(3R,4R)-3-(hydroxycarbamoyl)t…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
ADA17-1-E ADAM17 (cluster #1 Of 2), Eukaryotic Eukaryotes 130 0.29 Binding ≤ 10μM
ATS4-1-E ADAMTS4 (cluster #1 Of 1), Eukaryotic Eukaryotes 6700 0.22 Binding ≤ 10μM
ATS5-1-E ADAMTS5 (cluster #1 Of 1), Eukaryotic Eukaryotes 1900 0.24 Binding ≤ 10μM
MMP12-1-E Macrophage Metalloelastase (cluster #1 Of 2), Eukaryotic Eukaryotes 8000 0.22 Binding ≤ 10μM
Z102213-1-O Blood (cluster #1 Of 2), Other Other 232 0.28 Functional ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.55 6.11 -22.99 3 8 0 105 462.428 6 ↓

Analogs

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Popular Name: (2S)-5'-ethyl-5-phenyl-spiro[3H-1,3,4-thiadiazole-2,3'-indoline]-2'-one (2S)-5'-ethyl-5-phenyl-spiro[3H-…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
ATS5-1-E ADAMTS5 (cluster #1 Of 1), Eukaryotic Eukaryotes 9600 0.32 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.50 6.31 -10.15 2 4 0 53 309.394 2 ↓

Analogs

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Popular Name: (2R)-5'-ethyl-5-phenyl-spiro[3H-1,3,4-thiadiazole-2,3'-indoline]-2'-one (2R)-5'-ethyl-5-phenyl-spiro[3H-…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
ATS5-1-E ADAMTS5 (cluster #1 Of 1), Eukaryotic Eukaryotes 9600 0.32 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.50 6.32 -10.11 2 4 0 53 309.394 2 ↓

Analogs

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Popular Name: (2R)-5'-methyl-5-(p-tolyl)spiro[3H-1,3,4-thiadiazole-2,3'-indoline]-2'-one (2R)-5'-methyl-5-(p-tolyl)spiro[…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
ATS5-1-E ADAMTS5 (cluster #1 Of 1), Eukaryotic Eukaryotes 3000 0.35 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.48 -3.64 -10.15 2 4 0 53 309.394 1 ↓

Analogs

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Popular Name: (2S)-5'-methyl-5-(p-tolyl)spiro[3H-1,3,4-thiadiazole-2,3'-indoline]-2'-one (2S)-5'-methyl-5-(p-tolyl)spiro[…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
ATS5-1-E ADAMTS5 (cluster #1 Of 1), Eukaryotic Eukaryotes 3000 0.35 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.48 -3.64 -10.12 2 4 0 53 309.394 1 ↓

Analogs

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Popular Name: (5E)-5-[[4-[(4-chlorophenyl)methoxy]-3-methoxy-phenyl]methylene]-2-thioxo-thiazolidin-4-one (5E)-5-[[4-[(4-chlorophenyl)meth…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
ATS5-1-E ADAMTS5 (cluster #1 Of 1), Eukaryotic Eukaryotes 3500 0.31 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.74 9.21 -11.99 1 4 0 51 391.901 5 ↓

Analogs

26531247
26531247
1188278
1188278
4109097
4109097

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Popular Name: 2-[(5E)-5-[(3,4-dibenzyloxyphenyl)methylene]-4-oxo-2-thioxo-thiazolidin-3-yl]acetic 2-[(5E)-5-[(3,4-dibenzyloxypheny…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
ATS5-1-E ADAMTS5 (cluster #1 Of 1), Eukaryotic Eukaryotes 6700 0.21 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.98 14.71 -59.26 0 6 -1 81 490.582 9 ↓

Analogs

33902
33902
342072
342072
342075
342075

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Popular Name: (2R)-1'-methyl-5-(p-tolyl)spiro[3H-1,3,4-thiadiazole-2,3'-indoline]-2'-one (2R)-1'-methyl-5-(p-tolyl)spiro[…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
ATS5-1-E ADAMTS5 (cluster #1 Of 1), Eukaryotic Eukaryotes 4600 0.34 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.30 -2.14 -11.35 1 4 0 44 309.394 1 ↓

Analogs

342072
342072
342075
342075
33901
33901

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Popular Name: (2S)-1'-methyl-5-(p-tolyl)spiro[3H-1,3,4-thiadiazole-2,3'-indoline]-2'-one (2S)-1'-methyl-5-(p-tolyl)spiro[…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
ATS5-1-E ADAMTS5 (cluster #1 Of 1), Eukaryotic Eukaryotes 4600 0.34 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.30 -2.14 -11.36 1 4 0 44 309.394 1 ↓

Analogs

15821826
15821826

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Popular Name: N-[(R)-(5-chloro-8-hydroxy-7-quinolyl)-(p-tolyl)methyl]-2-phenoxy-acetamide N-[(R)-(5-chloro-8-hydroxy-7-qui…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
ATS5-1-E ADAMTS5 (cluster #1 Of 1), Eukaryotic Eukaryotes 760 0.28 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 5.32 10.1 -17.41 2 5 0 71 432.907 6 ↓
Lo Low (pH 4.5-6) 5.32 10.45 -45.23 3 5 1 73 433.915 6 ↓

Analogs

15821823
15821823

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Popular Name: N-[(S)-(5-chloro-8-hydroxy-7-quinolyl)-(p-tolyl)methyl]-2-phenoxy-acetamide N-[(S)-(5-chloro-8-hydroxy-7-qui…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
ATS5-1-E ADAMTS5 (cluster #1 Of 1), Eukaryotic Eukaryotes 760 0.28 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 5.32 10.15 -17.47 2 5 0 71 432.907 6 ↓
Lo Low (pH 4.5-6) 5.32 10.51 -44.83 3 5 1 73 433.915 6 ↓

Analogs

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Popular Name: N-(4'-Chloro-4-biphenylylsulfonyl)phenylalanine N-(4'-Chloro-4-biphenylylsulfony…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
ATS5-1-E ADAMTS5 (cluster #1 Of 1), Eukaryotic Eukaryotes 3200 0.27 Binding ≤ 10μM
MMP2-1-E 72 KDa Type IV Collagenase (cluster #1 Of 3), Eukaryotic Eukaryotes 2000 0.28 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.06 9.96 -54.51 1 5 -1 86 414.89 7 ↓

Analogs

1169970
1169970

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Popular Name: N-[(S)-(5-chloro-8-hydroxy-7-quinolyl)-(4-methoxyphenyl)methyl]-2-phenoxy-acetamide N-[(S)-(5-chloro-8-hydroxy-7-qui…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
ATS5-1-E ADAMTS5 (cluster #1 Of 1), Eukaryotic Eukaryotes 1000 0.26 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 4.93 9.18 -20.34 2 6 0 81 448.906 7 ↓
Hi High (pH 8-9.5) 4.93 9.75 -63.24 1 6 -1 84 447.898 7 ↓

Analogs

1169969
1169969

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Popular Name: N-[(R)-(5-chloro-8-hydroxy-7-quinolyl)-(4-methoxyphenyl)methyl]-2-phenoxy-acetamide N-[(R)-(5-chloro-8-hydroxy-7-qui…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
ATS5-1-E ADAMTS5 (cluster #1 Of 1), Eukaryotic Eukaryotes 1000 0.26 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 4.93 9.11 -20.61 2 6 0 81 448.906 7 ↓
Hi High (pH 8-9.5) 4.93 9.67 -64.4 1 6 -1 84 447.898 7 ↓

Analogs

1170062
1170062

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Popular Name: N-[(S)-(5-chloro-8-hydroxy-7-quinolyl)-(4-chlorophenyl)methyl]-2-phenoxy-acetamide N-[(S)-(5-chloro-8-hydroxy-7-qui…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
ATS5-1-E ADAMTS5 (cluster #1 Of 1), Eukaryotic Eukaryotes 830 0.27 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 5.55 9.97 -17.35 2 5 0 71 453.325 6 ↓
Hi High (pH 8-9.5) 5.55 10.72 -56.91 1 5 -1 74 452.317 6 ↓
Hi High (pH 8-9.5) 5.74 7.51 -42.89 1 5 -1 78 452.317 6 ↓

Analogs

1170061
1170061

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Popular Name: N-[(R)-(5-chloro-8-hydroxy-7-quinolyl)-(4-chlorophenyl)methyl]-2-phenoxy-acetamide N-[(R)-(5-chloro-8-hydroxy-7-qui…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
ATS5-1-E ADAMTS5 (cluster #1 Of 1), Eukaryotic Eukaryotes 830 0.27 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 5.55 9.95 -17.15 2 5 0 71 453.325 6 ↓
Hi High (pH 8-9.5) 5.74 7.46 -43.53 1 5 -1 78 452.317 6 ↓
Hi High (pH 8-9.5) 5.55 10.7 -56.83 1 5 -1 74 452.317 6 ↓

Analogs

1169901
1169901

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Popular Name: N-[(S)-(5-chloro-8-hydroxy-7-quinolyl)-(4-nitrophenyl)methyl]-2-phenoxy-acetamide N-[(S)-(5-chloro-8-hydroxy-7-qui…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
ATS5-1-E ADAMTS5 (cluster #1 Of 1), Eukaryotic Eukaryotes 460 0.27 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 4.84 10.17 -20.97 2 8 0 117 463.877 7 ↓
Hi High (pH 8-9.5) 5.02 7.71 -40.57 1 8 -1 124 462.869 7 ↓
Hi High (pH 8-9.5) 4.84 10.9 -52.51 1 8 -1 120 462.869 7 ↓

Analogs

1169900
1169900

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Popular Name: N-[(R)-(5-chloro-8-hydroxy-7-quinolyl)-(4-nitrophenyl)methyl]-2-phenoxy-acetamide N-[(R)-(5-chloro-8-hydroxy-7-qui…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
ATS5-1-E ADAMTS5 (cluster #1 Of 1), Eukaryotic Eukaryotes 460 0.27 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 4.84 10.14 -20.66 2 8 0 117 463.877 7 ↓
Hi High (pH 8-9.5) 5.02 7.65 -41.14 1 8 -1 124 462.869 7 ↓
Hi High (pH 8-9.5) 4.84 10.91 -52.43 1 8 -1 120 462.869 7 ↓

Parameters Provided:

target.name = ATS5-1-E
target.type = B10
page.format = summary
page.num = 1
filter.purchasability = purchasable

Structural Results Found: (before additional filtering)

SQL Query Was

SELECT DISTINCT(ci.sub_id_fk) AS sub_id FROM catalog_item AS ci INNER JOIN catalog AS c ON ci.cat_id_fk=c.cat_id INNER JOIN activity AS ac ON ci.sub_id_fk=ac.sub_id_fk INNER JOIN target AS t ON ac.target_fk=t.target_id  WHERE c.free = 1 AND t.code LIKE 'ATS5-1-E' AND t.atype_fk = 0 AND c.purchasable IN (1,2,4,5)    LIMIT 50

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