UCSF
ZINC Item Suppliers, Protomers, & Similar Substances

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Popular Name: Dibenzo[cd,g]indazol-6(2H)-one Dibenzo[cd,g]indazol-6(2H)-one

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
AAK1-2-E Adaptor-associated Kinase (cluster #2 Of 2), Eukaryotic Eukaryotes 35 0.61 Binding ≤ 10μM
AURKA-2-E Serine/threonine-protein Kinase Aurora-A (cluster #2 Of 3), Eukaryotic Eukaryotes 980 0.49 Binding ≤ 10μM
AURKC-2-E Serine/threonine-protein Kinase Aurora-C (cluster #2 Of 2), Eukaryotic Eukaryotes 5300 0.43 Binding ≤ 10μM
BMP2K-2-E BMP-2-inducible Protein Kinase (cluster #2 Of 2), Eukaryotic Eukaryotes 25 0.63 Binding ≤ 10μM
CDK16-1-E Serine/threonine-protein Kinase PCTAIRE-1 (cluster #1 Of 1), Eukaryotic Eukaryotes 180 0.56 Binding ≤ 10μM
CDK2-5-E Cyclin-dependent Kinase 2 (cluster #5 Of 5), Eukaryotic Eukaryotes 3200 0.45 Binding ≤ 10μM
CLK2-2-E Dual Specificity Protein Kinase CLK2 (cluster #2 Of 2), Eukaryotic Eukaryotes 300 0.54 Binding ≤ 10μM
CLK4-2-E Dual Specificity Protein Kinase CLK4 (cluster #2 Of 2), Eukaryotic Eukaryotes 260 0.54 Binding ≤ 10μM
DAPK2-2-E Death-associated Protein Kinase 2 (cluster #2 Of 2), Eukaryotic Eukaryotes 610 0.51 Binding ≤ 10μM
DAPK3-2-E Death-associated Protein Kinase 3 (cluster #2 Of 2), Eukaryotic Eukaryotes 410 0.53 Binding ≤ 10μM
E2AK2-1-E Interferon-induced, Double-stranded RNA-activated Protein Kinase (cluster #1 Of 1), Eukaryotic Eukaryotes 8000 0.42 Binding ≤ 10μM
EPHA3-2-E Ephrin Type-A Receptor 3 (cluster #2 Of 2), Eukaryotic Eukaryotes 4000 0.44 Binding ≤ 10μM
GAK-2-E Serine/threonine-protein Kinase GAK (cluster #2 Of 2), Eukaryotic Eukaryotes 38 0.61 Binding ≤ 10μM
JAK3-2-E Tyrosine-protein Kinase JAK3 (cluster #2 Of 2), Eukaryotic Eukaryotes 957 0.50 Binding ≤ 10μM
KC1E-2-E Casein Kinase I Epsilon (cluster #2 Of 2), Eukaryotic Eukaryotes 3100 0.45 Binding ≤ 10μM
KC1G1-2-E Casein Kinase I Gamma 1 (cluster #2 Of 2), Eukaryotic Eukaryotes 3700 0.45 Binding ≤ 10μM
KCC1A-2-E CaM Kinase I Alpha (cluster #2 Of 2), Eukaryotic Eukaryotes 4100 0.44 Binding ≤ 10μM
KCC1D-2-E CaM Kinase I Delta (cluster #2 Of 2), Eukaryotic Eukaryotes 1400 0.48 Binding ≤ 10μM
KCC1G-2-E CaM Kinase I Gamma (cluster #2 Of 2), Eukaryotic Eukaryotes 4200 0.44 Binding ≤ 10μM
KKCC2-2-E CaM-kinase Kinase Beta (cluster #2 Of 2), Eukaryotic Eukaryotes 7500 0.42 Binding ≤ 10μM
KS6A2-2-E Ribosomal Protein S6 Kinase Alpha 2 (cluster #2 Of 2), Eukaryotic Eukaryotes 2200 0.47 Binding ≤ 10μM
KS6A5-1-E Ribosomal Protein S6 Kinase Alpha 5 (cluster #1 Of 3), Eukaryotic Eukaryotes 1700 0.48 Binding ≤ 10μM
MARK2-2-E MAP/microtubule Affinity-regulating Kinase 2 (cluster #2 Of 2), Eukaryotic Eukaryotes 1800 0.47 Binding ≤ 10μM
MK08-5-E Mitogen-activated Protein Kinase 8 (cluster #5 Of 5), Eukaryotic Eukaryotes 40 0.61 Binding ≤ 10μM
MK09-3-E C-Jun N-terminal Kinase 2 (cluster #3 Of 3), Eukaryotic Eukaryotes 84 0.58 Binding ≤ 10μM
MK10-2-E C-Jun N-terminal Kinase 3 (cluster #2 Of 2), Eukaryotic Eukaryotes 90 0.58 Binding ≤ 10μM
MK12-2-E MAP Kinase P38 Gamma (cluster #2 Of 2), Eukaryotic Eukaryotes 2400 0.46 Binding ≤ 10μM
MKNK2-2-E MAP Kinase Signal-integrating Kinase 2 (cluster #2 Of 2), Eukaryotic Eukaryotes 1000 0.49 Binding ≤ 10μM
PHKG2-2-E Phosphorylase Kinase Gamma Subunit 2 (cluster #2 Of 2), Eukaryotic Eukaryotes 480 0.52 Binding ≤ 10μM
PIM2-2-E Serine/threonine-protein Kinase PIM2 (cluster #2 Of 2), Eukaryotic Eukaryotes 460 0.52 Binding ≤ 10μM
PLK4-1-E Serine/threonine-protein Kinase PLK4 (cluster #1 Of 1), Eukaryotic Eukaryotes 770 0.50 Binding ≤ 10μM
SLK-2-E Serine/threonine-protein Kinase 2 (cluster #2 Of 2), Eukaryotic Eukaryotes 2300 0.46 Binding ≤ 10μM
ST17A-2-E Serine/threonine-protein Kinase 17A (cluster #2 Of 2), Eukaryotic Eukaryotes 2100 0.47 Binding ≤ 10μM
ST38L-2-E Serine/threonine-protein Kinase 38-like (cluster #2 Of 2), Eukaryotic Eukaryotes 2300 0.46 Binding ≤ 10μM
STK16-1-E Serine/threonine-protein Kinase 16 (cluster #1 Of 1), Eukaryotic Eukaryotes 510 0.52 Binding ≤ 10μM
STK3-2-E Serine/threonine-protein Kinase MST2 (cluster #2 Of 2), Eukaryotic Eukaryotes 220 0.55 Binding ≤ 10μM
STK4-2-E Serine/threonine-protein Kinase MST1 (cluster #2 Of 2), Eukaryotic Eukaryotes 2200 0.47 Binding ≤ 10μM
TNIK-2-E TRAF2- And NCK-interacting Kinase (cluster #2 Of 2), Eukaryotic Eukaryotes 480 0.52 Binding ≤ 10μM
TTK-2-E Dual Specificity Protein Kinase TTK (cluster #2 Of 2), Eukaryotic Eukaryotes 98 0.58 Binding ≤ 10μM
ULK3-2-E Serine/threonine-protein Kinase ULK3 (cluster #2 Of 2), Eukaryotic Eukaryotes 680 0.51 Binding ≤ 10μM
Z50425-3-O Plasmodium Falciparum (cluster #3 Of 22), Other Other 7943 0.42 Functional ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.48 6.16 -10.65 1 3 0 46 220.231 0 ↓
Mid Mid (pH 6-8) 3.49 4.15 -24.93 1 3 0 46 220.231 0 ↓
Mid Mid (pH 6-8) 3.48 6.17 -10.96 1 3 0 46 220.231 0 ↓

Parameters Provided:

target.name = BMP2K-2-E
target.type = B10
page.format = summary
page.num = 1
filter.purchasability = purchasable

Structural Results Found: (before additional filtering)

SQL Query Was

SELECT DISTINCT(ci.sub_id_fk) AS sub_id FROM catalog_item AS ci INNER JOIN catalog AS c ON ci.cat_id_fk=c.cat_id INNER JOIN activity AS ac ON ci.sub_id_fk=ac.sub_id_fk INNER JOIN target AS t ON ac.target_fk=t.target_id  WHERE c.free = 1 AND t.code LIKE 'BMP2K-2-E' AND t.atype_fk = 0 AND c.purchasable IN (1,2,4,5)    LIMIT 50

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