ZINC 12

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
CSK21-3-E	Casein Kinase II Alpha (cluster #3 Of 3), Eukaryotic	Eukaryotes	900	0.65	Binding ≤ 10μM
CSK2B-2-E	Casein Kinase II Beta (cluster #2 Of 3), Eukaryotic	Eukaryotes	500	0.68	Binding ≤ 10μM
DYR1A-2-E	Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1A (cluster #2 Of 3), Eukaryotic	Eukaryotes	1000	0.65	Binding ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.29	3.88	-2.56	1	3	0	42	434.711	0	↓ MOL2 SDF SMILES Flexibase

13585914

Analogs

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Vendors

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
CSK21-3-E	Casein Kinase II Alpha (cluster #3 Of 3), Eukaryotic	Eukaryotes	360	0.64	Binding ≤ 10μM
CSK22-2-E	Casein Kinase II Alpha (prime) (cluster #2 Of 2), Eukaryotic	Eukaryotes	360	0.64	Binding ≤ 10μM
CSK2B-2-E	Casein Kinase II Beta (cluster #2 Of 3), Eukaryotic	Eukaryotes	360	0.64	Binding ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.07	3.53	-3.89	2	3	0	49	449.722	0	↓ MOL2 SDF SMILES Flexibase

28636280

Analogs

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Vendors

Chembo Pharma
- KB-261371

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
CSK21-3-E	Casein Kinase II Alpha (cluster #3 Of 3), Eukaryotic	Eukaryotes	740	0.61	Binding ≤ 10μM
CSK22-2-E	Casein Kinase II Alpha (prime) (cluster #2 Of 2), Eukaryotic	Eukaryotes	740	0.61	Binding ≤ 10μM
CSK2B-2-E	Casein Kinase II Beta (cluster #2 Of 3), Eukaryotic	Eukaryotes	740	0.61	Binding ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.56	6.12	-3.25	1	2	0	29	512.619	0	↓ MOL2 SDF SMILES Flexibase

2528524

Analogs

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Popular Name: DNC014860 DNC014860

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Vendors

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
CSK21-3-E	Casein Kinase II Alpha (cluster #3 Of 3), Eukaryotic	Eukaryotes	500	0.68	Binding ≤ 10μM
CSK22-2-E	Casein Kinase II Alpha (prime) (cluster #2 Of 2), Eukaryotic	Eukaryotes	500	0.68	Binding ≤ 10μM
CSK2B-2-E	Casein Kinase II Beta (cluster #2 Of 3), Eukaryotic	Eukaryotes	500	0.68	Binding ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.43	6.37	-7.11	1	2	0	29	433.723	0	↓ MOL2 SDF SMILES Flexibase

8830553

Analogs

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Vendors

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
CCNA1-3-E	Cyclin A1 (cluster #3 Of 3), Eukaryotic	Eukaryotes	2380	0.49	Binding ≤ 10μM
CCNA2-3-E	Cyclin A2 (cluster #3 Of 3), Eukaryotic	Eukaryotes	2380	0.49	Binding ≤ 10μM
CDK2-5-E	Cyclin-dependent Kinase 2 (cluster #5 Of 5), Eukaryotic	Eukaryotes	2380	0.49	Binding ≤ 10μM
CSK21-3-E	Casein Kinase II Alpha (cluster #3 Of 3), Eukaryotic	Eukaryotes	5790	0.46	Binding ≤ 10μM
CSK22-2-E	Casein Kinase II Alpha (prime) (cluster #2 Of 2), Eukaryotic	Eukaryotes	5790	0.46	Binding ≤ 10μM
CSK2B-2-E	Casein Kinase II Beta (cluster #2 Of 3), Eukaryotic	Eukaryotes	5790	0.46	Binding ≤ 10μM
DYR1A-2-E	Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1A (cluster #2 Of 3), Eukaryotic	Eukaryotes	120	0.61	Binding ≤ 10μM
KPBB-2-E	Phosphorylase Kinase Beta Subunit (cluster #2 Of 2), Eukaryotic	Eukaryotes	7040	0.45	Binding ≤ 10μM
PHKG1-2-E	Phosphorylase Kinase Gamma Subunit 1 (cluster #2 Of 2), Eukaryotic	Eukaryotes	7040	0.45	Binding ≤ 10μM
PHKG2-2-E	Phosphorylase Kinase Gamma Subunit 2 (cluster #2 Of 2), Eukaryotic	Eukaryotes	7040	0.45	Binding ≤ 10μM
SGK1-2-E	Serine/threonine-protein Kinase Sgk1 (cluster #2 Of 2), Eukaryotic	Eukaryotes	3570	0.48	Binding ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.85	8.43	-5.86	1	3	0	32	476.792	1	↓ MOL2 SDF SMILES Flexibase

Parameters Provided:

target.name = CSK2B-2-E
target.type = B10
page.format = summary
page.num = 1
filter.purchasability = purchasable

Structural Results Found: (before additional filtering)

SQL Query Was

SELECT DISTINCT(ci.sub_id_fk) AS sub_id FROM catalog_item AS ci INNER JOIN catalog AS c ON ci.cat_id_fk=c.cat_id INNER JOIN activity AS ac ON ci.sub_id_fk=ac.sub_id_fk INNER JOIN target AS t ON ac.target_fk=t.target_id  WHERE c.free = 1 AND t.code LIKE 'CSK2B-2-E' AND t.atype_fk = 0 AND c.purchasable IN (1,2,4,5)    LIMIT 50

Permalink

//zinc12.docking.org/results/combination?target.name=CSK2B-2-E&target.type=B10&filter.purchasability=purchasable

Embed Link to Results

<div id="zinc-link"></div>
<script type="text/javascript" src="//zinc12.docking.org/js/embed.js"></script>
<script type="text/javascript">
    window.zinc.embed('zinc-link', {
        "target.name": "CSK2B-2-E",        
        "target.type": "B10"        

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