UCSF
ZINC Item Suppliers, Protomers, & Similar Substances

Analogs

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Popular Name: CFM 1571 HYDROCHLORIDE CFM 1571 HYDROCHLORIDE

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Vendors

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
GCYA1-1-E Guanylate Cyclase Soluble Alpha-1 Chain (cluster #1 Of 1), Eukaryotic Eukaryotes 5490 0.25 Binding ≤ 10μM
GCYB1-1-E Guanylate Cyclase Soluble Beta-1 Chain (cluster #1 Of 1), Eukaryotic Eukaryotes 5490 0.25 Binding ≤ 10μM
Z50587-4-O Homo Sapiens (cluster #4 Of 9), Other Other 2840 0.26 Functional ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.65 8.42 -43.44 2 7 1 70 409.51 10 ↓

Analogs

3643093
3643093
3643095
3643095
39927984
39927984
39927985
39927985

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Popular Name: Benzydamine hydrochloride Benzydamine hydrochloride

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Vendors

And 41 More

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
GCYA1-1-E Guanylate Cyclase Soluble Alpha-1 Chain (cluster #1 Of 1), Eukaryotic Eukaryotes 1020 0.36 Binding ≤ 10μM
GCYA2-1-E Guanylate Cyclase Soluble Alpha-2 Chain (cluster #1 Of 1), Eukaryotic Eukaryotes 1020 0.36 Binding ≤ 10μM
GCYA3-1-E Guanylate Cyclase Soluble Alpha-3 Chain (cluster #1 Of 1), Eukaryotic Eukaryotes 1020 0.36 Binding ≤ 10μM
GCYB1-1-E Guanylate Cyclase Soluble Beta-1 Chain (cluster #1 Of 1), Eukaryotic Eukaryotes 1020 0.36 Binding ≤ 10μM
GCYB2-1-E Guanylate Cyclase Soluble Beta-2 Chain (cluster #1 Of 1), Eukaryotic Eukaryotes 1020 0.36 Binding ≤ 10μM
Z50587-4-O Homo Sapiens (cluster #4 Of 9), Other Other 6670 0.32 Functional ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.77 9.34 -38.79 1 4 1 31 310.421 7 ↓

Parameters Provided:

target.name = GCYB1-1-E
target.type = B10
page.format = summary
page.num = 1
filter.purchasability = purchasable

Structural Results Found: (before additional filtering)

SQL Query Was

SELECT DISTINCT(ci.sub_id_fk) AS sub_id FROM catalog_item AS ci INNER JOIN catalog AS c ON ci.cat_id_fk=c.cat_id INNER JOIN activity AS ac ON ci.sub_id_fk=ac.sub_id_fk INNER JOIN target AS t ON ac.target_fk=t.target_id  WHERE c.free = 1 AND t.code LIKE 'GCYB1-1-E' AND t.atype_fk = 0 AND c.purchasable IN (1,2,4,5)    LIMIT 50

Permalink

//zinc12.docking.org/results/combination?target.name=GCYB1-1-E&target.type=B10&filter.purchasability=purchasable

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