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Popular Name: 5-[(4-phenylphenyl)methylene]-2-sulfanyl-1H-pyrimidine-4,6-dione 5-[(4-phenylphenyl)methylene]-2-…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
SIRT2-1-E NAD-dependent Deacetylase Sirtuin 2 (cluster #1 Of 3), Eukaryotic Eukaryotes 8700 0.32 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.89 6.45 -39.89 1 4 -1 69 307.354 2 ↓
Lo Low (pH 4.5-6) 2.43 7.52 -11.15 2 4 0 66 308.362 2 ↓
Lo Low (pH 4.5-6) 2.89 6.44 -39.37 1 4 -1 69 307.354 2 ↓

Parameters Provided:

target.name = SIRT2-1-E
target.type = B10
page.format = summary
page.num = 1
filter.purchasability = purchasable

Structural Results Found: (before additional filtering)

SQL Query Was

SELECT DISTINCT(ci.sub_id_fk) AS sub_id FROM catalog_item AS ci INNER JOIN catalog AS c ON ci.cat_id_fk=c.cat_id INNER JOIN activity AS ac ON ci.sub_id_fk=ac.sub_id_fk INNER JOIN target AS t ON ac.target_fk=t.target_id  WHERE c.free = 1 AND t.code LIKE 'SIRT2-1-E' AND t.atype_fk = 0 AND c.purchasable IN (1,2,4,5)    LIMIT 50

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