| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| May 16th, 2008 | 22 | No |
Popular Name: Gliclazide Gliclazide
Find On: PubMed — Wikipedia — Google
CAS Numbers: 21187-98-4 , [21187-98-4]
1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea
1-(3-Azabicyclo(3.3.0)oct-3-yl)-3-(p-tolylsulfonyl)urea
1-(3-Azabicyclo[3.3.0]oct-3-yl)-3-p-tolylsulphonylurea
1-(Hexahydrocyclopenta(c)pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)urea
21187-98-4; D01599; Gliclazide (JP16/INN); Glimicron (TN)
21187-98-4; Gliclazide; Prestwick_869
3-{hexahydro-1H-cyclopenta[c]pyrrol-2-yl}-1-(4-methylbenzenesulfonyl)urea
Benzenesulfonamide, N-(((hexahydrocyclopenta(c)pyrrol-2(1H)-yl)amino)carbonyl)-4-methyl-
benzenesulfonamide, N-[[(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)amino]carbonyl]-4-methyl-
N-(4-Methylbenzenesulfonyl)-N'-(3-azabicyclo(3.3.0)oct-3-yl)urea
N-(hexahydrocyclopenta[c]pyrrol-2(1H)-ylcarbamoyl)-4-methylbenzenesulfonamide
N-[(hexahydrocyclopenta[c]pyrrol-2(1H)-ylamino)carbonyl]-4-methylbenzenesulfonamide
Urea, 1-(hexahydrocyclopenta(c)pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)-
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 2.25 | 2.31 | -56.61 | 1 | 6 | -1 | 85 | 322.41 | 4 | ↓ |
| Ref Reference (pH 7) | 2.25 | 1.53 | -17.49 | 2 | 6 | 0 | 82 | 323.418 | 4 | ↓ |
| Lo Low (pH 4.5-6) | 1.45 | 4.55 | -10.75 | 2 | 6 | 0 | 79 | 323.418 | 3 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| ALOGPS_SOLUBILITY | 1.90e-01 g/l | DrugBank-approved |
| biological_use | Antidiabetic | IBScreen Bioactives |
| therap | antidiabetic, adhesion inhibitor | MicroSource World Drugs |
| biological_use | Antidiabetic | IBScreen Bioactives |
| mechanism | Appears to enhance glucose stimulated insulin secretion at a submaximally stimulating blood-glucose level | IBScreen Bioactives |
| Patent Database Links | EP1258253; EP1452526; EP1452530; EP1479666; EP1500403; EP1514550; EP1520582; EP1533292; EP1553091; EP1559710; EP1595544; EP1669345; EP1671637; EP1700848; EP1741435; EP1743655; EP1745775; EP1785144; EP1813273; EP1829858; EP1832576; EP1840134; EP1862450; EP | ChEBI |
| biological_use | Oral antihyperglycaemic agent | IBScreen Bioactives |
| Target | Others | Selleck Chemicals |
| Target | Potassium Channel | Selleck Chemicals |
| PUBCHEM_PATENT_ID | US4137100; US5595743; US6156312 | IBM Patent Data |
