UCSF

ZINC01530611

Draw Identity 99% 90% 80% 70%

Substance Information

In ZINC since Heavy atoms Benign functionality
October 6th, 2004 20 Yes

Popular Name: Desipramine hydrochloride Desipramine hydrochloride

Find On: PubMed — Wikipedia — Google

CAS Numbers: 303-48-0 , 50-47-5 , 52-28-6 , 58-28-6 , 58-28-6, 50-47-5 , 58-28-6, 50-47-5 [desipramine] , [50-47-5]

Other Names:

(3-(10H,11H-Dibenzo[b,f]azepin-5-yl)propyl)methylamine

pramine

10, 11-Dihydro-N-methyl-5H-dibez[b,f]azepine-5-propanamine

10,11-Dihydro-5-(3-(methylamino)prop-yl)-5h-dibenz(b,f)azepine hydro-chloride

10,11-Dihydro-5-(3-(methylamino)propyl)-5H-dibenz(b,f)azepine hydrochloride; 10,11-Dihydro-5-(3-(methylamino)propyl)-5H-dibenz(b,f)azepine monohydrochloride; 5H-Dibenz(b,f)azepine, 10,11-dihydro-5-(3-(methylamino)propyl)-, hydrochloride; 5H-Dibenz(b,f)aze

10,11-Dihydro-5-(3-(methylamino)propyl)-5H-dibenz(b,f)azepine hydrochloride; 10,11-Dihydro-5-(3-(methylamino)propyl)-5H-dibenz(b,f)azepine monohydrochloride; DMI hydrochloride; Demethylimipramine hydrochloride; Desimipramine, hydrochloride; Desipramine HC

10,11-Dihydro-5-(3-methylaminopropyl)-5H-dibenz(b,f)azepine

18-8181; DMI; EX 4355; EX-4355; G-35020; JB-8181; RMI-9384A

18-8181; EX 4355; EX-4355; G-35020; JB-8181; RMI-9384A

3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine

3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine hydrochloride

3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methylpropan-1-amine

5-(gamma-Methylaminopropyl)iminodibenzyl

5-(gamma-methylaminopropyl)iminodibenzyl; DMI; Desipramin; N-(3-methylaminopropyl)iminobibenzyl; demethylimipramine; desmethylimipramine; monodemethylimipramine; norimipramine

50-47-5

50-47-5; C06943; Desipramine

50-47-5; D07791; Desipramine (INN)

58-28-6 (hydrochloride)

58-28-6; D00812; Desipramine hydrochloride (JAN/USP); Norpramin (TN)

58-28-6; Desipramine hydrochloride; Prestwick_706

5H-Dibenz(b,f)azepine, 10,11-dihydro-5-(3-(methylamino)propyl)-

5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N-methyl-

5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N-methyl-

5H-dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N-methyl-, hydrochloride

5H-dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N-methyl-, monohydrochloride

AB00053450

AC-15977

AC1L1EXQ

AKOS001681456

BPBio1_000447

BRN 1432747

BSPBio_000405

BSPBio_002137

C06943

CAS-58-28-6

CCRIS 7091

CHEBI:47393; CHEBI:4448

CHEBI:47781

CHEMBL72

CID2995

CPD000036827; Desipramine hydrochloride; SAM002264605

CPD000036827; Norpramin; SAM002264605

D07791

DAP001151

DB01151

DB07682

Demethylimipramine

Demethylimipramine;Desimipramine;Desimpramine;Desipramin;Desmethylimipramine;Dezipramine;Dimethylimipramine;Methylaminopropyliminodibenzyl;Monodemethylimipramine;Norimipramine;Norpramine

Desimipramine

Desimpramine

Desipramin

Desipramina

Desipramina [INN-Spanish]

desipramina; desipramine; desipraminum

Desipramine

Desipramine (BAN

Desipramine (D4)

Desipramine (INN)

Desipramine Hcl

Desipramine Hydrochloride

Desipramine [INN:BAN]

desipraminum

Desipraminum [INN-Latin]

Desmethylimipramine

Dezipramine

Dimethylimipramine

DivK1c_000190

DMI

DMI (pharmaceutical)

DMI 50475

EINECS 200-040-0

EX-4355

FDA)

G-35020

HSDB 3052

IDI1_000190

Imipramine, demethyl-

INN); Desipramine HCl (FDA

INN); Desipramine HCl (JAN

INN); Desipramine Hydrochloride (FDA

JAN

JB-8181

KBio1_000190

KBio2_000921

KBio2_003489

KBio2_006057

KBio3_001357

KBioGR_000928

KBioSS_000921

L001089

LS-60421

Methylaminopropyliminodibenzyl

MFCD00058108

MFCD00242884

MolPort-002-051-955

Monodemethylimipramine

N-(3-Methylaminopropyl)iminobibenzyl

N-[3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]-N-methylamine hydrochloride

NCGC00015340-01

NCGC00015340-02

NCGC00015340-03

NCGC00015340-10

NCGC00024375-04

NINDS_000190

Norimipramine

Norpramin

Norpramine

Nortimil

Pentofran

Pertofran

Pertofrane

Pertrofane

Prestwick0_000343

Prestwick1_000343

Prestwick2_000343

Prestwick3_000343

RMI-9384A

Sertofran

SPBio_000042

SPBio_002326

Spectrum2_000091

Spectrum3_000379

Spectrum4_000314

Spectrum5_000833

Spectrum_000441

STK735144

STOCK2S-34822

UNII-TG537D343B

USAN

USP

USP)

ZERO/006017

[3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]methylamine hydrochloride

Download: MOL2 SDF SMILES Flexibase

Annotations

Vendors

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.92 10.5 -39.26 2 2 1 20 267.396 4 ↓

Vendor Notes

Note Type Comments Provided By
ALOGPS_SOLUBILITY 3.96e-02 g/l DrugBank-approved
Therapy Antidepressant SMDC Iconix
UniProt Database Links CCAMK_MEDTR; CHDM_DROME; S22A4_RAT ChEBI
Patent Database Links EP0908186; EP1627639; EP1649857; EP1671628; EP1700616; EP1795196; EP1815846; EP1829527; EP1829528; EP1829539; EP1844769; EP1946777; EP1990639; US2002147336; US2004068017; US2004142904; US2004171682; US2004176595; US2004254182; US2005070552; US2005281845 ChEBI
Patent Database Links EP1655029; US2007185018 ChEBI
PUBCHEM_SUBSTANCE_COMMENT NCC_SAMPLE_SUPPLIER : LightBiologicals; NCC_SUPPLIER_STRUCTURE_ID : D-3326; 1 hydrogen chloride NIH Clinical Collection via PubChem
Reactome Database Links REACT_22167; REACT_22373 ChEBI
PUBCHEM_SUBSTANCE_COMMENT SAMPLE_SUPPLIER: LightBiologicals; SUPPLIER_STRUCTURE_ID: D-3326; SALT: 1 hydrogen chloride NIH Clinical Collection via PubChem

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
5HT1A-1-E Serotonin 1a (5-HT1a) Receptor (cluster #1 Of 4), Eukaryotic Eukaryotes 350 0.45 Binding ≤ 10μM
5HT1B-1-E Serotonin 1b (5-HT1b) Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 350 0.45 Binding ≤ 10μM
5HT1D-1-E Serotonin 1d (5-HT1d) Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 350 0.45 Binding ≤ 10μM
5HT1F-1-E Serotonin 1f (5-HT1f) Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 350 0.45 Binding ≤ 10μM
5HT2A-1-E Serotonin 2a (5-HT2a) Receptor (cluster #1 Of 3), Eukaryotic Eukaryotes 160 0.48 Binding ≤ 10μM
5HT2B-1-E Serotonin 2b (5-HT2b) Receptor (cluster #1 Of 4), Eukaryotic Eukaryotes 350 0.45 Binding ≤ 10μM
5HT2C-1-E Serotonin 2c (5-HT2c) Receptor (cluster #1 Of 3), Eukaryotic Eukaryotes 350 0.45 Binding ≤ 10μM
5HT4R-1-E Serotonin 4 (5-HT4) Receptor (cluster #1 Of 1), Eukaryotic Eukaryotes 350 0.45 Binding ≤ 10μM
5HT5A-1-E Serotonin 5a (5-HT5a) Receptor (cluster #1 Of 1), Eukaryotic Eukaryotes 350 0.45 Binding ≤ 10μM
5HT5B-1-E Serotonin 5b (5-HT5b) Receptor (cluster #1 Of 1), Eukaryotic Eukaryotes 350 0.45 Binding ≤ 10μM
5HT6R-1-E Serotonin 6 (5-HT6) Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 350 0.45 Binding ≤ 10μM
5HT7R-1-E Serotonin 7 (5-HT7) Receptor (cluster #1 Of 3), Eukaryotic Eukaryotes 350 0.45 Binding ≤ 10μM
ADA1A-2-E Alpha-1a Adrenergic Receptor (cluster #2 Of 3), Eukaryotic Eukaryotes 2 0.61 Binding ≤ 10μM
ADA1B-1-E Alpha-1b Adrenergic Receptor (cluster #1 Of 4), Eukaryotic Eukaryotes 2 0.61 Binding ≤ 10μM
ADA1D-1-E Alpha-1d Adrenergic Receptor (cluster #1 Of 3), Eukaryotic Eukaryotes 2 0.61 Binding ≤ 10μM
ADA2A-3-E Alpha-2a Adrenergic Receptor (cluster #3 Of 4), Eukaryotic Eukaryotes 2 0.61 Binding ≤ 10μM
ADA2B-1-E Alpha-2b Adrenergic Receptor (cluster #1 Of 4), Eukaryotic Eukaryotes 2 0.61 Binding ≤ 10μM
ADA2C-3-E Alpha-2c Adrenergic Receptor (cluster #3 Of 4), Eukaryotic Eukaryotes 2 0.61 Binding ≤ 10μM
ADCY1-1-E Brain Adenylate Cyclase 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 350 0.45 Binding ≤ 10μM
ADCY2-2-E Adenylate Cyclase Type II (cluster #2 Of 2), Eukaryotic Eukaryotes 350 0.45 Binding ≤ 10μM
ADCY8-1-E Adenylate Cyclase Type VIII (cluster #1 Of 2), Eukaryotic Eukaryotes 350 0.45 Binding ≤ 10μM
ADRB1-1-E Beta-1 Adrenergic Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 2 0.61 Binding ≤ 10μM
ADRB2-1-E Beta-2 Adrenergic Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 2 0.61 Binding ≤ 10μM
ADRB3-1-E Beta-3 Adrenergic Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 2 0.61 Binding ≤ 10μM
HRH1-2-E Histamine H1 Receptor (cluster #2 Of 2), Eukaryotic Eukaryotes 1 0.63 Binding ≤ 10μM
KCNH2-5-E HERG (cluster #5 Of 5), Eukaryotic Eukaryotes 5820 0.37 Binding ≤ 10μM
Q63380-1-E Transporter (cluster #1 Of 1), Eukaryotic Eukaryotes 1 0.63 Binding ≤ 10μM
Q9WTR4-1-E Norepinephrine Transporter (cluster #1 Of 2), Eukaryotic Eukaryotes 7 0.57 Binding ≤ 10μM
SC6A2-1-E Norepinephrine Transporter (cluster #1 Of 2), Eukaryotic Eukaryotes 580 0.44 Binding ≤ 10μM
SC6A3-1-E Dopamine Transporter (cluster #1 Of 3), Eukaryotic Eukaryotes 3000 0.39 Binding ≤ 10μM
SC6A4-3-E Serotonin Transporter (cluster #3 Of 4), Eukaryotic Eukaryotes 182 0.47 Binding ≤ 10μM
SCN1A-1-E Sodium Channel Protein Type I Alpha Subunit (cluster #1 Of 2), Eukaryotic Eukaryotes 2400 0.39 Binding ≤ 10μM
SCN2A-1-E Sodium Channel Protein Type II Alpha Subunit (cluster #1 Of 2), Eukaryotic Eukaryotes 2400 0.39 Binding ≤ 10μM
SCN3A-1-E Sodium Channel Protein Type III Alpha Subunit (cluster #1 Of 2), Eukaryotic Eukaryotes 2400 0.39 Binding ≤ 10μM
SCN8A-1-E Sodium Channel Protein Type VIII Alpha Subunit (cluster #1 Of 2), Eukaryotic Eukaryotes 2400 0.39 Binding ≤ 10μM
HRH2-1-E Histamine H2 Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 3800 0.38 Functional ≤ 10μM
Q9WTR4-1-E Norepinephrine Transporter (cluster #1 Of 2), Eukaryotic Eukaryotes 70 0.50 Functional ≤ 10μM
SC6A3-1-E Dopamine Transporter (cluster #1 Of 1), Eukaryotic Eukaryotes 7800 0.36 Functional ≤ 10μM
SC6A4-1-E Serotonin Transporter (cluster #1 Of 1), Eukaryotic Eukaryotes 3000 0.39 Functional ≤ 10μM
Z50597-1-O Rattus Norvegicus (cluster #1 Of 5), Other Other 6532 0.36 Binding ≤ 10μM
Z50425-3-O Plasmodium Falciparum (cluster #3 Of 22), Other Other 1585 0.41 Functional ≤ 10μM
Z50590-1-O Sus Scrofa (cluster #1 Of 1), Other Other 6100 0.37 Functional ≤ 10μM
Z50594-6-O Mus Musculus (cluster #6 Of 9), Other Other 70 0.50 Functional ≤ 10μM
Z50597-12-O Rattus Norvegicus (cluster #12 Of 12), Other Other 80 0.50 Functional ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
ADCY2_HUMAN Q08462 Adenylate Cyclase Type II, Human 320 0.45 Binding ≤ 1μM
ADCY8_HUMAN P40145 Adenylate Cyclase Type VIII, Human 320 0.45 Binding ≤ 1μM
ADA1A_RAT P43140 Alpha-1a Adrenergic Receptor, Rat 0.25 0.67 Binding ≤ 1μM
ADA1B_RAT P15823 Alpha-1b Adrenergic Receptor, Rat 2 0.61 Binding ≤ 1μM
ADA1D_RAT P23944 Alpha-1d Adrenergic Receptor, Rat 2 0.61 Binding ≤ 1μM
ADA2A_RAT P22909 Alpha-2a Adrenergic Receptor, Rat 2 0.61 Binding ≤ 1μM
ADA2B_RAT P19328 Alpha-2b Adrenergic Receptor, Rat 2 0.61 Binding ≤ 1μM
ADA2C_RAT P22086 Alpha-2c Adrenergic Receptor, Rat 2 0.61 Binding ≤ 1μM
ADRB1_RAT P18090 Beta-1 Adrenergic Receptor, Rat 2 0.61 Binding ≤ 1μM
ADRB2_RAT P10608 Beta-2 Adrenergic Receptor, Rat 2 0.61 Binding ≤ 1μM
ADRB3_RAT P26255 Beta-3 Adrenergic Receptor, Rat 2 0.61 Binding ≤ 1μM
ADCY1_HUMAN Q08828 Brain Adenylate Cyclase 1, Human 320 0.45 Binding ≤ 1μM
SC6A3_HUMAN Q01959 Dopamine Transporter, Human 0.49 0.65 Binding ≤ 1μM
HRH1_RAT P31390 Histamine H1 Receptor, Rat 0.8 0.64 Binding ≤ 1μM
SC6A2_HUMAN P23975 Norepinephrine Transporter, Human 0.8 0.64 Binding ≤ 1μM
Q9WTR4_RAT Q9WTR4 Norepinephrine Transporter, Rat 0.65 0.64 Binding ≤ 1μM
Z50597 Z50597 Rattus Norvegicus 0.65 0.64 Binding ≤ 1μM
5HT1A_RAT P19327 Serotonin 1a (5-HT1a) Receptor, Rat 350 0.45 Binding ≤ 1μM
5HT1B_RAT P28564 Serotonin 1b (5-HT1b) Receptor, Rat 350 0.45 Binding ≤ 1μM
5HT1D_RAT P28565 Serotonin 1d (5-HT1d) Receptor, Rat 350 0.45 Binding ≤ 1μM
5HT1F_RAT P30940 Serotonin 1f (5-HT1f) Receptor, Rat 350 0.45 Binding ≤ 1μM
5HT2A_RAT P14842 Serotonin 2a (5-HT2a) Receptor, Rat 350 0.45 Binding ≤ 1μM
5HT2A_HUMAN P28223 Serotonin 2a (5-HT2a) Receptor, Human 160 0.48 Binding ≤ 1μM
5HT2B_RAT P30994 Serotonin 2b (5-HT2b) Receptor, Rat 350 0.45 Binding ≤ 1μM
5HT2C_RAT P08909 Serotonin 2c (5-HT2c) Receptor, Rat 350 0.45 Binding ≤ 1μM
5HT4R_RAT Q62758 Serotonin 4 (5-HT4) Receptor, Rat 350 0.45 Binding ≤ 1μM
5HT5A_RAT P35364 Serotonin 5a (5-HT5a) Receptor, Rat 350 0.45 Binding ≤ 1μM
5HT5B_RAT P35365 Serotonin 5b (5-HT5b) Receptor, Rat 350 0.45 Binding ≤ 1μM
5HT6R_RAT P31388 Serotonin 6 (5-HT6) Receptor, Rat 350 0.45 Binding ≤ 1μM
5HT7R_RAT P32305 Serotonin 7 (5-HT7) Receptor, Rat 350 0.45 Binding ≤ 1μM
SC6A4_RAT P31652 Serotonin Transporter, Rat 182 0.47 Binding ≤ 1μM
SC6A4_HUMAN P31645 Serotonin Transporter, Human 108 0.49 Binding ≤ 1μM
Q63380_RAT Q63380 Transporter, Rat 0.78 0.64 Binding ≤ 1μM
ADCY2_HUMAN Q08462 Adenylate Cyclase Type II, Human 320 0.45 Binding ≤ 10μM
ADCY8_HUMAN P40145 Adenylate Cyclase Type VIII, Human 320 0.45 Binding ≤ 10μM
ADA1A_RAT P43140 Alpha-1a Adrenergic Receptor, Rat 0.25 0.67 Binding ≤ 10μM
ADA1B_RAT P15823 Alpha-1b Adrenergic Receptor, Rat 2 0.61 Binding ≤ 10μM
ADA1D_RAT P23944 Alpha-1d Adrenergic Receptor, Rat 2 0.61 Binding ≤ 10μM
ADA2A_RAT P22909 Alpha-2a Adrenergic Receptor, Rat 2 0.61 Binding ≤ 10μM
ADA2B_RAT P19328 Alpha-2b Adrenergic Receptor, Rat 2 0.61 Binding ≤ 10μM
ADA2C_RAT P22086 Alpha-2c Adrenergic Receptor, Rat 2 0.61 Binding ≤ 10μM
ADRB1_RAT P18090 Beta-1 Adrenergic Receptor, Rat 2 0.61 Binding ≤ 10μM
ADRB2_RAT P10608 Beta-2 Adrenergic Receptor, Rat 2 0.61 Binding ≤ 10μM
ADRB3_RAT P26255 Beta-3 Adrenergic Receptor, Rat 2 0.61 Binding ≤ 10μM
ADCY1_HUMAN Q08828 Brain Adenylate Cyclase 1, Human 320 0.45 Binding ≤ 10μM
SC6A3_HUMAN Q01959 Dopamine Transporter, Human 0.49 0.65 Binding ≤ 10μM
SC6A3_RAT P23977 Dopamine Transporter, Rat 6532 0.36 Binding ≤ 10μM
KCNH2_HUMAN Q12809 HERG, Human 1380.38426 0.41 Binding ≤ 10μM
HRH1_RAT P31390 Histamine H1 Receptor, Rat 0.8 0.64 Binding ≤ 10μM
Q9WTR4_RAT Q9WTR4 Norepinephrine Transporter, Rat 0.65 0.64 Binding ≤ 10μM
SC6A2_HUMAN P23975 Norepinephrine Transporter, Human 0.8 0.64 Binding ≤ 10μM
Z50597 Z50597 Rattus Norvegicus 0.65 0.64 Binding ≤ 10μM
5HT1A_RAT P19327 Serotonin 1a (5-HT1a) Receptor, Rat 350 0.45 Binding ≤ 10μM
5HT1B_RAT P28564 Serotonin 1b (5-HT1b) Receptor, Rat 350 0.45 Binding ≤ 10μM
5HT1D_RAT P28565 Serotonin 1d (5-HT1d) Receptor, Rat 350 0.45 Binding ≤ 10μM
5HT1F_RAT P30940 Serotonin 1f (5-HT1f) Receptor, Rat 350 0.45 Binding ≤ 10μM
5HT2A_HUMAN P28223 Serotonin 2a (5-HT2a) Receptor, Human 160 0.48 Binding ≤ 10μM
5HT2A_RAT P14842 Serotonin 2a (5-HT2a) Receptor, Rat 350 0.45 Binding ≤ 10μM
5HT2B_RAT P30994 Serotonin 2b (5-HT2b) Receptor, Rat 350 0.45 Binding ≤ 10μM
5HT2C_RAT P08909 Serotonin 2c (5-HT2c) Receptor, Rat 350 0.45 Binding ≤ 10μM
5HT4R_RAT Q62758 Serotonin 4 (5-HT4) Receptor, Rat 350 0.45 Binding ≤ 10μM
5HT5A_RAT P35364 Serotonin 5a (5-HT5a) Receptor, Rat 350 0.45 Binding ≤ 10μM
5HT5B_RAT P35365 Serotonin 5b (5-HT5b) Receptor, Rat 350 0.45 Binding ≤ 10μM
5HT6R_RAT P31388 Serotonin 6 (5-HT6) Receptor, Rat 350 0.45 Binding ≤ 10μM
5HT7R_RAT P32305 Serotonin 7 (5-HT7) Receptor, Rat 350 0.45 Binding ≤ 10μM
SC6A4_RAT P31652 Serotonin Transporter, Rat 182 0.47 Binding ≤ 10μM
SC6A4_HUMAN P31645 Serotonin Transporter, Human 108 0.49 Binding ≤ 10μM
SCN1A_HUMAN P35498 Sodium Channel Protein Type I Alpha Subunit, Human 2400 0.39 Binding ≤ 10μM
SCN2A_HUMAN Q99250 Sodium Channel Protein Type II Alpha Subunit, Human 2400 0.39 Binding ≤ 10μM
SCN3A_HUMAN Q9NY46 Sodium Channel Protein Type III Alpha Subunit, Human 2400 0.39 Binding ≤ 10μM
SCN8A_HUMAN Q9UQD0 Sodium Channel Protein Type VIII Alpha Subunit, Human 2400 0.39 Binding ≤ 10μM
Q63380_RAT Q63380 Transporter, Rat 0.78 0.64 Binding ≤ 10μM
SC6A3_RAT P23977 Dopamine Transporter, Rat 7800 0.36 Functional ≤ 10μM
HRH2_HUMAN P25021 Histamine H2 Receptor, Human 3800 0.38 Functional ≤ 10μM
Z50594 Z50594 Mus Musculus 70 0.50 Functional ≤ 10μM
Q9WTR4_RAT Q9WTR4 Norepinephrine Transporter, Rat 150 0.48 Functional ≤ 10μM
Z50425 Z50425 Plasmodium Falciparum 10000 0.35 Functional ≤ 10μM
Z50597 Z50597 Rattus Norvegicus 11 0.56 Functional ≤ 10μM
SC6A4_RAT P31652 Serotonin Transporter, Rat 3000 0.39 Functional ≤ 10μM
Z50590 Z50590 Sus Scrofa 3.2 0.59 Functional ≤ 10μM

Direct Reactome Annotations (via ChEBI)

Description Species
Organic cation transport

Reactome Annotations from Targets (via Uniprot)

Description Species
Adenylate cyclase activating pathway
Adenylate cyclase inhibitory pathway
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
Adrenoceptors
CREB phosphorylation through the activation of Adenylate Cyclase
Dopamine clearance from the synaptic cleft
G alpha (12/13) signalling events
G alpha (i) signalling events
G alpha (q) signalling events
G alpha (s) signalling events
G alpha (z) signalling events
Glucagon signaling in metabolic regulation
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Histamine receptors
Interaction between L1 and Ankyrins
Na+/Cl- dependent neurotransmitter transporters
PKA activation
PKA activation in glucagon signalling
Serotonin receptors
Vasopressin regulates renal water homeostasis via Aquaporins
Voltage gated Potassium channels

Analogs ( Draw Identity 99% 90% 80% 70% )