| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 6th, 2004 | 19 | Yes |
Popular Name: Tetracaine hydrochloride Tetracaine hydrochloride
Find On: PubMed — Wikipedia — Google
CAS Numbers: 136-47-0 , 136-47-0, 94-24-6 , 136-47-0, 94-24-6 [tetracaine] , 94-24-6 , [136-47-0] , [94-24-6]
136-47-0; D00741; Protocaine hydrochloride (TN); Tetracaine hydrochloride (JP16/USP)
2-(Dimethylamino)ethyl 4-(butylamino)benzoate
2-(dimethylamino)ethyl 4-(butylamino)benzoate hydrochloride
2-(Dimethylamino)ethyl 4-(butylamino)benzoate hydrochloride (1:1)
2-(Dimethylamino)ethyl 4-(butylamino)benzoic acid hydrochloride
2-(Dimethylamino)ethyl p-(butylamino)benzoate
2-dimethylaminoethyl 4-(butylamino)benzoate
2-Dimethylaminoethylester kyseliny p-butylaminobenzoove
2-Dimethylaminoethylester kyseliny p-butylaminobenzoove [Czech]
4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester
4-14-00-01172 (Beilstein Handbook Reference)
4-[Butylamino]benzoic acid-2-[dimethylamino]ethyl ester
94-24-6; Amethocaine; C07526; Tetracaine
Amethocaine (BAN); Tetracaine (BAN
Amethocaine (BAN); Tetracaine (FDA
Benzoic acid, 4-(butylamino)-, 2-(dimethylamino)ethyl ester
benzoic acid, 4-(butylamino)-, 2-(dimethylamino)ethyl ester ,hydrochloride
benzoic acid, 4-(butylamino)-, 2-(dimethylamino)ethyl ester, monohydrochloride
BENZOIC ACID, p-(BUTYLAMINO)-, 2-(DIMETHYLAMINO)ETHYL ESTER
BENZOIC ACID,4-BUTYLAMINO,2-DIMETHYLAMINOETHYL ESTER PANTOCAIN BASE
Diaethylaminoaethanol ester der p-butylaminobenzoesaeure
Diaethylaminoaethanol ester der p-butylaminobenzoesaeure [German]
Dimethylaminoethyl p-butyl-aminobenzoate
InChI=1/C15H24N2O2/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3/h6-9,16H,4-5,10-12H2,1-3H
LIDOCAINE; LIDOCAINE AND TETRACAINE; LS-187998; TETRACAINE
p-(Butylamino)benzoic acid, 2-(dimethylamino)ethyl ester
p-Butylaminobenzoyl-2-dimethylaminoethanol
tetracaina; tetracaine; tetracainum
Tetracaine hydrochloride (Pontocaine)
USP); Amethocaine HCl (BAN); Tetracaine HCl (BAN
USP); Amethocaine Hydrochloride (BAN); Tetracaine Hydrochloride (BAN
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.43 | 8.62 | -37.54 | 2 | 4 | 1 | 43 | 265.377 | 9 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| Molecular_Solubility | 3.066 | Bitter DB |
| MP | 149 | TCI |
| Indications | anesthetic | KeyOrganics Bioactives |
| therap | anesthetic (local) | MicroSource Spectrum |
| Target | Calcium Channel | Selleck Chemicals |
| Therapy | Local anesthetic | SMDC Iconix |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| CNGA1-1-E | CGMP-gated Cation Channel Alpha 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 6800 | 0.38 | Binding ≤ 10μM |
| SCN1A-2-E | Sodium Channel Protein Type I Alpha Subunit (cluster #2 Of 2), Eukaryotic | Eukaryotes | 3400 | 0.40 | Binding ≤ 10μM |
| SCN2A-1-E | Sodium Channel Protein Type II Alpha Subunit (cluster #1 Of 2), Eukaryotic | Eukaryotes | 3400 | 0.40 | Binding ≤ 10μM |
| SCN3A-2-E | Sodium Channel Protein Type III Alpha Subunit (cluster #2 Of 2), Eukaryotic | Eukaryotes | 3400 | 0.40 | Binding ≤ 10μM |
| SCN8A-2-E | Sodium Channel Protein Type VIII Alpha Subunit (cluster #2 Of 2), Eukaryotic | Eukaryotes | 3400 | 0.40 | Binding ≤ 10μM |
| SCN9A-1-E | Sodium Channel Protein Type IX Alpha Subunit (cluster #1 Of 1), Eukaryotic | Eukaryotes | 7510 | 0.38 | Binding ≤ 10μM |
| SCN1A-2-E | Sodium Channel Protein Type I Alpha Subunit (cluster #2 Of 2), Eukaryotic | Eukaryotes | 400 | 0.47 | Functional ≤ 10μM |
| SCN2A-3-E | Sodium Channel Protein Type II Alpha Subunit (cluster #3 Of 3), Eukaryotic | Eukaryotes | 400 | 0.47 | Functional ≤ 10μM |
| SCN3A-2-E | Sodium Channel Protein Type III Alpha Subunit (cluster #2 Of 2), Eukaryotic | Eukaryotes | 400 | 0.47 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| SCN9A_HUMAN | Q15858 | Sodium Channel Protein Type IX Alpha Subunit, Human | 500 | 0.46 | Binding ≤ 1μM |
| CNGA1_BOVIN | Q00194 | CGMP-gated Cation Channel Alpha 1, Bovin | 6800 | 0.38 | Binding ≤ 10μM |
| SCN1A_HUMAN | P35498 | Sodium Channel Protein Type I Alpha Subunit, Human | 3400 | 0.40 | Binding ≤ 10μM |
| SCN1A_RAT | P04774 | Sodium Channel Protein Type I Alpha Subunit, Rat | 6000 | 0.38 | Binding ≤ 10μM |
| SCN2A_RAT | P04775 | Sodium Channel Protein Type II Alpha Subunit, Rat | 6000 | 0.38 | Binding ≤ 10μM |
| SCN2A_HUMAN | Q99250 | Sodium Channel Protein Type II Alpha Subunit, Human | 3400 | 0.40 | Binding ≤ 10μM |
| SCN3A_RAT | P08104 | Sodium Channel Protein Type III Alpha Subunit, Rat | 6000 | 0.38 | Binding ≤ 10μM |
| SCN3A_HUMAN | Q9NY46 | Sodium Channel Protein Type III Alpha Subunit, Human | 3400 | 0.40 | Binding ≤ 10μM |
| SCN9A_HUMAN | Q15858 | Sodium Channel Protein Type IX Alpha Subunit, Human | 500 | 0.46 | Binding ≤ 10μM |
| SCN8A_RAT | O88420 | Sodium Channel Protein Type VIII Alpha Subunit, Rat | 6000 | 0.38 | Binding ≤ 10μM |
| SCN8A_HUMAN | Q9UQD0 | Sodium Channel Protein Type VIII Alpha Subunit, Human | 3400 | 0.40 | Binding ≤ 10μM |
| SCN1A_HUMAN | P35498 | Sodium Channel Protein Type I Alpha Subunit, Human | 400 | 0.47 | Functional ≤ 10μM |
| SCN2A_HUMAN | Q99250 | Sodium Channel Protein Type II Alpha Subunit, Human | 400 | 0.47 | Functional ≤ 10μM |
| SCN3A_HUMAN | Q9NY46 | Sodium Channel Protein Type III Alpha Subunit, Human | 400 | 0.47 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Activation of the phototransduction cascade | |
| Inactivation, recovery and regulation of the phototransduction cascade | |
| Interaction between L1 and Ankyrins |
