| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| September 27th, 2005 | 27 | Yes |
Popular Name: CP-154526 CP-154526
Find On: PubMed — Wikipedia — Google
CAS Numbers: 157286-86-7 , 157286-86-7; 257639-98-8 , 257639-98-8
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 6.02 | 2.73 | -7.89 | 0 | 4 | 0 | 33 | 364.537 | 6 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| CRFR1-1-E | Corticotropin Releasing Factor Receptor 1 (cluster #1 Of 3), Eukaryotic | Eukaryotes | 6 | 0.43 | Binding ≤ 10μM |
| CRFR1-1-E | Corticotropin Releasing Factor Receptor 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3 | 0.44 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| CRFR1_HUMAN | P34998 | Corticotropin Releasing Factor Receptor 1, Human | 2.7 | 0.44 | Binding ≤ 1μM |
| CRFR1_RAT | P35353 | Corticotropin Releasing Factor Receptor 1, Rat | 5.5 | 0.43 | Binding ≤ 1μM |
| CRFR1_RAT | P35353 | Corticotropin Releasing Factor Receptor 1, Rat | 5.5 | 0.43 | Binding ≤ 10μM |
| CRFR1_HUMAN | P34998 | Corticotropin Releasing Factor Receptor 1, Human | 2.7 | 0.44 | Binding ≤ 10μM |
| CRFR1_HUMAN | P34998 | Corticotropin Releasing Factor Receptor 1, Human | 2.7 | 0.44 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Class B/2 (Secretin family receptors) | |
| G alpha (s) signalling events |
