| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 7th, 2004 | 29 | Yes |
None
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 2.77 | 1.32 | -13.26 | 2 | 9 | 0 | 116 | 404.371 | 6 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| TBB1-1-E | Tubulin Beta-1 Chain (cluster #1 Of 2), Eukaryotic | Eukaryotes | 830 | 0.29 | Binding ≤ 10μM |
| TBB3-1-E | Tubulin Beta-3 Chain (cluster #1 Of 1), Eukaryotic | Eukaryotes | 830 | 0.29 | Binding ≤ 10μM |
| TBB4A-1-E | Tubulin Beta-4 Chain (cluster #1 Of 1), Eukaryotic | Eukaryotes | 830 | 0.29 | Binding ≤ 10μM |
| TBB4B-1-E | Tubulin Beta-2 Chain (cluster #1 Of 1), Eukaryotic | Eukaryotes | 830 | 0.29 | Binding ≤ 10μM |
| TBB8-1-E | Tubulin Beta-8 Chain (cluster #1 Of 1), Eukaryotic | Eukaryotes | 830 | 0.29 | Binding ≤ 10μM |
| TBB1-1-E | Tubulin Beta-1 Chain (cluster #1 Of 2), Eukaryotic | Eukaryotes | 830 | 0.29 | Functional ≤ 10μM |
| TBB3-1-E | Tubulin Beta-3 Chain (cluster #1 Of 3), Eukaryotic | Eukaryotes | 830 | 0.29 | Functional ≤ 10μM |
| TBB4A-1-E | Tubulin Beta-4 Chain (cluster #1 Of 3), Eukaryotic | Eukaryotes | 830 | 0.29 | Functional ≤ 10μM |
| TBB4B-1-E | Tubulin Beta-2 Chain (cluster #1 Of 3), Eukaryotic | Eukaryotes | 830 | 0.29 | Functional ≤ 10μM |
| TBB8-1-E | Tubulin Beta-8 Chain (cluster #1 Of 3), Eukaryotic | Eukaryotes | 830 | 0.29 | Functional ≤ 10μM |
| Z80156-12-O | HL-60 (Promyeloblast Leukemia Cells) (cluster #12 Of 12), Other | Other | 36 | 0.36 | Functional ≤ 10μM |
| Z80166-1-O | HT-29 (Colon Adenocarcinoma Cells) (cluster #1 Of 12), Other | Other | 3140 | 0.27 | Functional ≤ 10μM |
| Z80186-5-O | K562 (Erythroleukemia Cells) (cluster #5 Of 11), Other | Other | 7 | 0.39 | Functional ≤ 10μM |
| Z80466-1-O | SF268 (cluster #1 Of 4), Other | Other | 186 | 0.32 | Functional ≤ 10μM |
| Z80493-2-O | SK-OV-3 (Ovarian Carcinoma Cells) (cluster #2 Of 6), Other | Other | 22 | 0.37 | Functional ≤ 10μM |
| Z80682-1-O | A549 (Lung Carcinoma Cells) (cluster #1 Of 11), Other | Other | 58 | 0.35 | Functional ≤ 10μM |
| Z80928-3-O | HCT-116 (Colon Carcinoma Cells) (cluster #3 Of 9), Other | Other | 23 | 0.37 | Functional ≤ 10μM |
| Z81020-7-O | HepG2 (Hepatoblastoma Cells) (cluster #7 Of 8), Other | Other | 174 | 0.33 | Functional ≤ 10μM |
| Z81115-1-O | KB (Squamous Cell Carcinoma) (cluster #1 Of 6), Other | Other | 8 | 0.39 | Functional ≤ 10μM |
| Z81335-4-O | HCT-15 (Colon Adenocarcinoma Cells) (cluster #4 Of 5), Other | Other | 14 | 0.38 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| TBB1_HUMAN | Q9H4B7 | Tubulin Beta-1 Chain, Human | 830 | 0.29 | Binding ≤ 1μM |
| TBB4B_HUMAN | P68371 | Tubulin Beta-2 Chain, Human | 830 | 0.29 | Binding ≤ 1μM |
| TBB3_HUMAN | Q13509 | Tubulin Beta-3 Chain, Human | 830 | 0.29 | Binding ≤ 1μM |
| TBB4A_HUMAN | P04350 | Tubulin Beta-4 Chain, Human | 830 | 0.29 | Binding ≤ 1μM |
| TBB8_HUMAN | Q3ZCM7 | Tubulin Beta-8 Chain, Human | 830 | 0.29 | Binding ≤ 1μM |
| TBB1_HUMAN | Q9H4B7 | Tubulin Beta-1 Chain, Human | 830 | 0.29 | Binding ≤ 10μM |
| TBB4B_HUMAN | P68371 | Tubulin Beta-2 Chain, Human | 830 | 0.29 | Binding ≤ 10μM |
| TBB3_HUMAN | Q13509 | Tubulin Beta-3 Chain, Human | 830 | 0.29 | Binding ≤ 10μM |
| TBB4A_HUMAN | P04350 | Tubulin Beta-4 Chain, Human | 830 | 0.29 | Binding ≤ 10μM |
| TBB8_HUMAN | Q3ZCM7 | Tubulin Beta-8 Chain, Human | 830 | 0.29 | Binding ≤ 10μM |
| Z80682 | Z80682 | A549 (Lung Carcinoma Cells) | 58 | 0.35 | Functional ≤ 10μM |
| Z80928 | Z80928 | HCT-116 (Colon Carcinoma Cells) | 23 | 0.37 | Functional ≤ 10μM |
| Z81335 | Z81335 | HCT-15 (Colon Adenocarcinoma Cells) | 14 | 0.38 | Functional ≤ 10μM |
| Z81020 | Z81020 | HepG2 (Hepatoblastoma Cells) | 174 | 0.33 | Functional ≤ 10μM |
| Z80156 | Z80156 | HL-60 (Promyeloblast Leukemia Cells) | 36 | 0.36 | Functional ≤ 10μM |
| Z80166 | Z80166 | HT-29 (Colon Adenocarcinoma Cells) | 3140 | 0.27 | Functional ≤ 10μM |
| Z80186 | Z80186 | K562 (Erythroleukemia Cells) | 7 | 0.39 | Functional ≤ 10μM |
| Z81115 | Z81115 | KB (Squamous Cell Carcinoma) | 20 | 0.37 | Functional ≤ 10μM |
| Z80466 | Z80466 | SF268 | 186 | 0.32 | Functional ≤ 10μM |
| Z80493 | Z80493 | SK-OV-3 (Ovarian Carcinoma Cells) | 22 | 0.37 | Functional ≤ 10μM |
| TBB1_HUMAN | Q9H4B7 | Tubulin Beta-1 Chain, Human | 830 | 0.29 | Functional ≤ 10μM |
| TBB4B_HUMAN | P68371 | Tubulin Beta-2 Chain, Human | 830 | 0.29 | Functional ≤ 10μM |
| TBB3_HUMAN | Q13509 | Tubulin Beta-3 Chain, Human | 830 | 0.29 | Functional ≤ 10μM |
| TBB4A_HUMAN | P04350 | Tubulin Beta-4 Chain, Human | 830 | 0.29 | Functional ≤ 10μM |
| TBB8_HUMAN | Q3ZCM7 | Tubulin Beta-8 Chain, Human | 830 | 0.29 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Formation of tubulin folding intermediates by CCT/TriC | |
| Gap junction assembly | |
| Kinesins | |
| Loss of Nlp from mitotic centrosomes | |
| Loss of proteins required for interphase microtubule organization from the ce | |
| MHC class II antigen presentation | |
| Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | |
| Mitotic Prometaphase | |
| Post-chaperonin tubulin folding pathway | |
| Prefoldin mediated transfer of substrate to CCT/TriC | |
| Recruitment of mitotic centrosome proteins and complexes | |
| Recruitment of NuMA to mitotic centrosomes | |
| Recycling pathway of L1 | |
| Regulation of PLK1 Activity at G2/M Transition | |
| Resolution of Sister Chromatid Cohesion | |
| Separation of Sister Chromatids | |
| Translocation of GLUT4 to the plasma membrane |
