| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 7th, 2004 | 26 | Yes |
Popular Name: (R)-Roscovitine (R)-Roscovitine
Find On: PubMed — Wikipedia — Google
CAS Numbers: 186692-44-4 , 186692-46-6 , [186692-46-6]
(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol
(2r)-2-{[6-(benzylamino)-9-isopropyl-9h-purin-2-yl]amino}-1-butanol
1-Butanol, 2-((9-(1-methylethyl)-6-((phenylmethyl)amino)-9H-purin-2- yl)amino)-, (2R)-
1-Butanol, 2-((9-(1-methylethyl)-6-((phenylmethyl)amino)-9H-purin-2- yl)amino)-, (R)-
1-Butanol, 2-((9-(1-methylethyl)-6-((phenylmethyl)amino)-9H-purin-2-yl)amino)-, (2R)-
1-Butanol, 2-((9-(1-methylethyl)-6-((phenylmethyl)amino)-9H-purin-2-yl)amino)-, (R)-
1-Butanol, 2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-, (2R)-
2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine
2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol
2-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]- 9H-purin-2-yl]amino]-(R)-1-butanol
2-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol
6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine
CYC202, Seliciclib, R-roscovitine, Roscovitine
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.65 | 9.65 | -10.26 | 3 | 7 | 0 | 88 | 354.458 | 8 | ↓ |
| Lo Low (pH 4.5-6) | 3.65 | 9.9 | -28.83 | 4 | 7 | 1 | 89 | 355.466 | 8 | ↓ |
| Lo Low (pH 4.5-6) | 3.65 | 9.47 | -25.05 | 4 | 7 | 1 | 89 | 355.466 | 8 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| MP | 106-107° | Oakwood Chemical |
| Purity | >95% | Fluorochem |
| Target | CDK | Selleck Chemicals |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| ALK-1-E | ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2300 | 0.30 | Binding ≤ 10μM |
| CCNA1-1-E | Cyclin A1 (cluster #1 Of 3), Eukaryotic | Eukaryotes | 700 | 0.33 | Binding ≤ 10μM |
| CCNA2-1-E | Cyclin A2 (cluster #1 Of 3), Eukaryotic | Eukaryotes | 700 | 0.33 | Binding ≤ 10μM |
| CCNB1-1-E | G2/mitotic-specific Cyclin B1 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 650 | 0.33 | Binding ≤ 10μM |
| CCNB2-1-E | G2/mitotic-specific Cyclin B2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 650 | 0.33 | Binding ≤ 10μM |
| CCNB3-1-E | G2/mitotic-specific Cyclin B3 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 650 | 0.33 | Binding ≤ 10μM |
| CCNE1-1-E | G1/S-specific Cyclin E1 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 700 | 0.33 | Binding ≤ 10μM |
| CCNE2-1-E | G1/S-specific Cyclin E2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 700 | 0.33 | Binding ≤ 10μM |
| CCNH-1-E | Cyclin H (cluster #1 Of 1), Eukaryotic | Eukaryotes | 540 | 0.34 | Binding ≤ 10μM |
| CCNT1-1-E | Cyclin T1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 950 | 0.32 | Binding ≤ 10μM |
| CCNT2-1-E | Cyclin-T2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 810 | 0.33 | Binding ≤ 10μM |
| CDK1-1-E | Cyclin-dependent Kinase 1 (cluster #1 Of 4), Eukaryotic | Eukaryotes | 650 | 0.33 | Binding ≤ 10μM |
| CDK1-1-E | Cyclin-dependent Kinase 1 (cluster #1 Of 4), Eukaryotic | Eukaryotes | 650 | 0.33 | Binding ≤ 10μM |
| CDK16-1-E | Serine/threonine-protein Kinase PCTAIRE-1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 990 | 0.32 | Binding ≤ 10μM |
| CDK2-1-E | Cyclin-dependent Kinase 2 (cluster #1 Of 5), Eukaryotic | Eukaryotes | 700 | 0.33 | Binding ≤ 10μM |
| CDK4-2-E | Cyclin-dependent Kinase 4 (cluster #2 Of 3), Eukaryotic | Eukaryotes | 100 | 0.38 | Binding ≤ 10μM |
| CDK5-1-E | Cyclin-dependent Kinase 5 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 160 | 0.37 | Binding ≤ 10μM |
| CDK5-1-E | Cyclin-dependent Kinase 5 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 270 | 0.35 | Binding ≤ 10μM |
| CDK7-1-E | Cyclin-dependent Kinase 7 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 800 | 0.33 | Binding ≤ 10μM |
| CDK9-1-E | Cyclin-dependent Kinase 9 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 950 | 0.32 | Binding ≤ 10μM |
| CLK1-2-E | Dual Specificty Protein Kinase CLK1 (cluster #2 Of 2), Eukaryotic | Eukaryotes | 2100 | 0.31 | Binding ≤ 10μM |
| CLK2-1-E | Dual Specificity Protein Kinase CLK2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 700 | 0.33 | Binding ≤ 10μM |
| CLK4-1-E | Dual Specificity Protein Kinase CLK4 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 4500 | 0.29 | Binding ≤ 10μM |
| DYR1A-3-E | Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1A (cluster #3 Of 3), Eukaryotic | Eukaryotes | 5000 | 0.29 | Binding ≤ 10μM |
| DYR1B-1-E | Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1B (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1100 | 0.32 | Binding ≤ 10μM |
| KC1D-1-E | Casein Kinase I Delta (cluster #1 Of 1), Eukaryotic | Eukaryotes | 260 | 0.35 | Binding ≤ 10μM |
| KC1E-1-E | Casein Kinase I Epsilon (cluster #1 Of 2), Eukaryotic | Eukaryotes | 320 | 0.35 | Binding ≤ 10μM |
| KC1G1-1-E | Casein Kinase I Gamma 1 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 3300 | 0.30 | Binding ≤ 10μM |
| KC1G2-1-E | Casein Kinase I Gamma 2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1400 | 0.32 | Binding ≤ 10μM |
| KC1G3-1-E | Casein Kinase I Isoform Gamma-3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2900 | 0.30 | Binding ≤ 10μM |
| KS6A2-1-E | Ribosomal Protein S6 Kinase Alpha 2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 3200 | 0.30 | Binding ≤ 10μM |
| MAT1-1-E | CDK-activating Kinase Assembly Factor MAT1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 540 | 0.34 | Binding ≤ 10μM |
| PAK4-1-E | Serine/threonine-protein Kinase PAK 4 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 6900 | 0.28 | Binding ≤ 10μM |
| TTK-1-E | Dual Specificity Protein Kinase TTK (cluster #1 Of 2), Eukaryotic | Eukaryotes | 2100 | 0.31 | Binding ≤ 10μM |
| Z104294-1-O | Cyclin-dependent Kinase 5/CDK5 Activator 1 (cluster #1 Of 2), Other | Other | 280 | 0.35 | Binding ≤ 10μM |
| Z104294-1-O | Cyclin-dependent Kinase 5/CDK5 Activator 1 (cluster #1 Of 2), Other | Other | 940 | 0.32 | Binding ≤ 10μM |
| Z104296-2-O | Cyclin-dependent Kinase 1/cyclin B1 (cluster #2 Of 2), Other | Other | 450 | 0.34 | Binding ≤ 10μM |
| Z104299-1-O | Cyclin-dependent Kinase 2/cyclin E1 (cluster #1 Of 1), Other | Other | 220 | 0.36 | Binding ≤ 10μM |
| Z50425-15-O | Plasmodium Falciparum (cluster #15 Of 22), Other | Other | 6310 | 0.28 | Functional ≤ 10μM |
| Z80054-1-O | Caco-2 (Colon Adenocarcinoma Cells) (cluster #1 Of 4), Other | Other | 6000 | 0.28 | Functional ≤ 10μM |
| Z80390-10-O | PC-3 (Prostate Carcinoma Cells) (cluster #10 Of 10), Other | Other | 8000 | 0.27 | Functional ≤ 10μM |
| Z80928-3-O | HCT-116 (Colon Carcinoma Cells) (cluster #3 Of 9), Other | Other | 5000 | 0.29 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| KC1D_HUMAN | P48730 | Casein Kinase I Delta, Human | 260 | 0.35 | Binding ≤ 1μM |
| KC1E_HUMAN | P49674 | Casein Kinase I Epsilon, Human | 160 | 0.37 | Binding ≤ 1μM |
| MAT1_HUMAN | P51948 | CDK-activating Kinase Assembly Factor MAT1, Human | 480 | 0.34 | Binding ≤ 1μM |
| CCNA1_HUMAN | P78396 | Cyclin A1, Human | 700 | 0.33 | Binding ≤ 1μM |
| CCNA2_HUMAN | P20248 | Cyclin A2, Human | 140 | 0.37 | Binding ≤ 1μM |
| CCNH_HUMAN | P51946 | Cyclin H, Human | 360 | 0.35 | Binding ≤ 1μM |
| CCNT1_HUMAN | O60563 | Cyclin T1, Human | 160 | 0.37 | Binding ≤ 1μM |
| CDK1_HUMAN | P06493 | Cyclin-dependent Kinase 1, Human | 200 | 0.36 | Binding ≤ 1μM |
| Z104296 | Z104296 | Cyclin-dependent Kinase 1/cyclin B1 | 450 | 0.34 | Binding ≤ 1μM |
| CDK2_HUMAN | P24941 | Cyclin-dependent Kinase 2, Human | 0.6 | 0.50 | Binding ≤ 1μM |
| Z104299 | Z104299 | Cyclin-dependent Kinase 2/cyclin E1 | 100 | 0.38 | Binding ≤ 1μM |
| CDK4_HUMAN | P11802 | Cyclin-dependent Kinase 4, Human | 100 | 0.38 | Binding ≤ 1μM |
| CDK5_HUMAN | Q00535 | Cyclin-dependent Kinase 5, Human | 160 | 0.37 | Binding ≤ 1μM |
| Z104294 | Z104294 | Cyclin-dependent Kinase 5/CDK5 Activator 1 | 160 | 0.37 | Binding ≤ 1μM |
| CDK7_HUMAN | P50613 | Cyclin-dependent Kinase 7, Human | 360 | 0.35 | Binding ≤ 1μM |
| CDK9_HUMAN | P50750 | Cyclin-dependent Kinase 9, Human | 230 | 0.36 | Binding ≤ 1μM |
| CCNT2_HUMAN | O60583 | Cyclin-T2, Human | 810 | 0.33 | Binding ≤ 1μM |
| CLK2_HUMAN | P49760 | Dual Specificity Protein Kinase CLK2, Human | 470 | 0.34 | Binding ≤ 1μM |
| CCNE1_HUMAN | P24864 | G1/S-specific Cyclin E1, Human | 100 | 0.38 | Binding ≤ 1μM |
| CCNE2_HUMAN | O96020 | G1/S-specific Cyclin E2, Human | 100 | 0.38 | Binding ≤ 1μM |
| CCNB1_HUMAN | P14635 | G2/mitotic-specific Cyclin B1, Human | 450 | 0.34 | Binding ≤ 1μM |
| CCNB2_HUMAN | O95067 | G2/mitotic-specific Cyclin B2, Human | 450 | 0.34 | Binding ≤ 1μM |
| CCNB3_HUMAN | Q8WWL7 | G2/mitotic-specific Cyclin B3, Human | 450 | 0.34 | Binding ≤ 1μM |
| CDK16_HUMAN | Q00536 | Serine/threonine-protein Kinase PCTAIRE-1, Human | 990 | 0.32 | Binding ≤ 1μM |
| ALK_HUMAN | Q9UM73 | ALK Tyrosine Kinase Receptor, Human | 2300 | 0.30 | Binding ≤ 10μM |
| KC1D_HUMAN | P48730 | Casein Kinase I Delta, Human | 260 | 0.35 | Binding ≤ 10μM |
| KC1E_HUMAN | P49674 | Casein Kinase I Epsilon, Human | 160 | 0.37 | Binding ≤ 10μM |
| KC1G1_HUMAN | Q9HCP0 | Casein Kinase I Gamma 1, Human | 3300 | 0.30 | Binding ≤ 10μM |
| KC1G2_HUMAN | P78368 | Casein Kinase I Gamma 2, Human | 1400 | 0.32 | Binding ≤ 10μM |
| KC1G3_HUMAN | Q9Y6M4 | Casein Kinase I Isoform Gamma-3, Human | 2900 | 0.30 | Binding ≤ 10μM |
| MAT1_HUMAN | P51948 | CDK-activating Kinase Assembly Factor MAT1, Human | 480 | 0.34 | Binding ≤ 10μM |
| CCNA1_HUMAN | P78396 | Cyclin A1, Human | 4600 | 0.29 | Binding ≤ 10μM |
| CCNA2_HUMAN | P20248 | Cyclin A2, Human | 140 | 0.37 | Binding ≤ 10μM |
| CCNH_HUMAN | P51946 | Cyclin H, Human | 360 | 0.35 | Binding ≤ 10μM |
| CCNT1_HUMAN | O60563 | Cyclin T1, Human | 160 | 0.37 | Binding ≤ 10μM |
| CDK1_HUMAN | P06493 | Cyclin-dependent Kinase 1, Human | 200 | 0.36 | Binding ≤ 10μM |
| Z104296 | Z104296 | Cyclin-dependent Kinase 1/cyclin B1 | 2100 | 0.31 | Binding ≤ 10μM |
| CDK2_HUMAN | P24941 | Cyclin-dependent Kinase 2, Human | 0.6 | 0.50 | Binding ≤ 10μM |
| Z104299 | Z104299 | Cyclin-dependent Kinase 2/cyclin E1 | 100 | 0.38 | Binding ≤ 10μM |
| CDK4_HUMAN | P11802 | Cyclin-dependent Kinase 4, Human | 100 | 0.38 | Binding ≤ 10μM |
| CDK5_HUMAN | Q00535 | Cyclin-dependent Kinase 5, Human | 160 | 0.37 | Binding ≤ 10μM |
| Z104294 | Z104294 | Cyclin-dependent Kinase 5/CDK5 Activator 1 | 160 | 0.37 | Binding ≤ 10μM |
| CDK7_HUMAN | P50613 | Cyclin-dependent Kinase 7, Human | 1800 | 0.31 | Binding ≤ 10μM |
| CDK9_HUMAN | P50750 | Cyclin-dependent Kinase 9, Human | 1770 | 0.31 | Binding ≤ 10μM |
| CCNT2_HUMAN | O60583 | Cyclin-T2, Human | 810 | 0.33 | Binding ≤ 10μM |
| CLK2_HUMAN | P49760 | Dual Specificity Protein Kinase CLK2, Human | 470 | 0.34 | Binding ≤ 10μM |
| CLK4_HUMAN | Q9HAZ1 | Dual Specificity Protein Kinase CLK4, Human | 4500 | 0.29 | Binding ≤ 10μM |
| TTK_HUMAN | P33981 | Dual Specificity Protein Kinase TTK, Human | 1600 | 0.31 | Binding ≤ 10μM |
| DYR1B_HUMAN | Q9Y463 | Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1B, Human | 1100 | 0.32 | Binding ≤ 10μM |
| CLK1_HUMAN | P49759 | Dual Specificty Protein Kinase CLK1, Human | 1200 | 0.32 | Binding ≤ 10μM |
| DYR1A_MOUSE | Q61214 | Dual-specificity Tyrosine-phosphorylation Regulated Kinase 1A, Mouse | 5000 | 0.29 | Binding ≤ 10μM |
| DYR1A_HUMAN | Q13627 | Dual-specificity Tyrosine-phosphorylation Regulated Kinase 1A, Human | 5000 | 0.29 | Binding ≤ 10μM |
| CCNE1_HUMAN | P24864 | G1/S-specific Cyclin E1, Human | 100 | 0.38 | Binding ≤ 10μM |
| CCNE2_HUMAN | O96020 | G1/S-specific Cyclin E2, Human | 100 | 0.38 | Binding ≤ 10μM |
| CCNB1_HUMAN | P14635 | G2/mitotic-specific Cyclin B1, Human | 450 | 0.34 | Binding ≤ 10μM |
| CCNB2_HUMAN | O95067 | G2/mitotic-specific Cyclin B2, Human | 450 | 0.34 | Binding ≤ 10μM |
| CCNB3_HUMAN | Q8WWL7 | G2/mitotic-specific Cyclin B3, Human | 450 | 0.34 | Binding ≤ 10μM |
| KS6A2_HUMAN | Q15349 | Ribosomal Protein S6 Kinase Alpha 2, Human | 3200 | 0.30 | Binding ≤ 10μM |
| PAK4_HUMAN | O96013 | Serine/threonine-protein Kinase PAK 4, Human | 6900 | 0.28 | Binding ≤ 10μM |
| CDK16_HUMAN | Q00536 | Serine/threonine-protein Kinase PCTAIRE-1, Human | 990 | 0.32 | Binding ≤ 10μM |
| Z80054 | Z80054 | Caco-2 (Colon Adenocarcinoma Cells) | 6000 | 0.28 | Functional ≤ 10μM |
| Z80928 | Z80928 | HCT-116 (Colon Carcinoma Cells) | 5000 | 0.29 | Functional ≤ 10μM |
| Z80390 | Z80390 | PC-3 (Prostate Carcinoma Cells) | 8000 | 0.27 | Functional ≤ 10μM |
| Z50425 | Z50425 | Plasmodium Falciparum | 3981.07171 | 0.29 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Activation of ATR in response to replication stress | |
| Activation of NIMA Kinases NEK9, NEK6, NEK7 | |
| Activation of Rac | |
| Activation of the pre-replicative complex | |
| APC/C:Cdc20 mediated degradation of Cyclin B | |
| CDK-mediated phosphorylation and removal of Cdc6 | |
| Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | |
| Circadian Clock | |
| Condensation of Prometaphase Chromosomes | |
| Condensation of Prophase Chromosomes | |
| CREB phosphorylation | |
| CREB phosphorylation through the activation of Ras | |
| CRMPs in Sema3A signaling | |
| Cyclin A/B1 associated events during G2/M transition | |
| Cyclin A:Cdk2-associated events at S phase entry | |
| Cyclin B2 mediated events | |
| Cyclin D associated events in G1 | |
| Cyclin E associated events during G1/S transition | |
| DARPP-32 events | |
| Depolymerisation of the Nuclear Lamina | |
| disassembly of the destruction complex and recruitment of AXIN to the membrane | |
| DNA Damage/Telomere Stress Induced Senescence | |
| Dual incision reaction in GG-NER | |
| Dual incision reaction in TC-NER | |
| E2F mediated regulation of DNA replication | |
| E2F-enabled inhibition of pre-replication complex formation | |
| ERK/MAPK targets | |
| ERK1 activation | |
| Factors involved in megakaryocyte development and platelet production | |
| Formation of HIV elongation complex in the absence of HIV Tat | |
| Formation of HIV-1 elongation complex containing HIV-1 Tat | |
| Formation of incision complex in GG-NER | |
| Formation of RNA Pol II elongation complex | |
| Formation of the Early Elongation Complex | |
| Formation of the HIV-1 Early Elongation Complex | |
| Formation of transcription-coupled NER (TC-NER) repair complex | |
| G0 and Early G1 | |
| G1/S-Specific Transcription | |
| G2 Phase | |
| G2/M DNA replication checkpoint | |
| Gastrin-CREB signalling pathway via PKC and MAPK | |
| Golgi Cisternae Pericentriolar Stack Reorganization | |
| HIV elongation arrest and recovery | |
| HIV Transcription Initiation | |
| Interactions of Tat with host cellular proteins | |
| Loss of Nlp from mitotic centrosomes | |
| Loss of proteins required for interphase microtubule organization from the ce | |
| MASTL Facilitates Mitotic Progression | |
| Meiotic recombination | |
| mRNA Capping | |
| NoRC negatively regulates rRNA expression | |
| Nuclear Pore Complex (NPC) Disassembly | |
| Oncogene Induced Senescence | |
| Orc1 removal from chromatin | |
| Oxidative Stress Induced Senescence | |
| p53-Dependent G1 DNA Damage Response | |
| Pausing and recovery of HIV elongation | |
| Pausing and recovery of Tat-mediated HIV elongation | |
| Phosphorylation of Emi1 | |
| Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 | |
| Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 com | |
| Phosphorylation of the APC/C | |
| Polo-like kinase mediated events | |
| Recruitment of mitotic centrosome proteins and complexes | |
| Recruitment of NuMA to mitotic centrosomes | |
| Recycling pathway of L1 | |
| Regulation of APC/C activators between G1/S and early anaphase | |
| Regulation of PLK1 Activity at G2/M Transition | |
| Resolution of Sister Chromatid Cohesion | |
| RMTs methylate histone arginines | |
| RNA Pol II CTD phosphorylation and interaction with CE | |
| RNA Polymerase I Chain Elongation | |
| RNA Polymerase I Promoter Escape | |
| RNA Polymerase I Transcription Initiation | |
| RNA Polymerase I Transcription Termination | |
| RNA Polymerase II HIV Promoter Escape | |
| RNA Polymerase II Pre-transcription Events | |
| RNA Polymerase II Promoter Escape | |
| RNA Polymerase II Transcription Elongation | |
| RNA Polymerase II Transcription Initiation | |
| RNA Polymerase II Transcription Initiation And Promoter Clearance | |
| RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | |
| RSK activation | |
| SCF(Skp2)-mediated degradation of p27/p21 | |
| Senescence-Associated Secretory Phenotype (SASP) | |
| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | |
| Sphingolipid de novo biosynthesis | |
| Tat-mediated elongation of the HIV-1 transcript | |
| Tat-mediated HIV elongation arrest and recovery | |
| Transcription of the HIV genome | |
| Transcriptional regulation of white adipocyte differentiation | |
| Ubiquitin-dependent degradation of Cyclin D1 | |
| WNT mediated activation of DVL |
