UCSF

ZINC00020248

Draw Identity 99% 90% 80% 70%

Substance Information

In ZINC since Heavy atoms Benign functionality
September 27th, 2005 22 Yes

Popular Name: Clomipramine hydrochloride Clomipramine hydrochloride

Find On: PubMed — Wikipedia — Google

CAS Numbers: 17321-77-6 , 17321-77-6, 303-49-1 , 17321-77-6, 303-49-1 [clomipramine] , 17321-77-6; 303-49-1 , 303-49-1 , [17321-77-6] , [303-49-1]

Other Names:

pramine

10,11-dihydro-3-chloro-5-(3-(dimethylamino)propyl)-5H-dibenz(b,f)azepine

17321-77-6 (mono-hydrochloride)

17321-77-6; Anafranil (TN); Clomipramine hydrochloride (JP16/USP); D00811

17321-77-6; Anafranil; CPD000058295; SAM002264601

17321-77-6; Clomipramine hydrochloride; Prestwick_72

3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine

3-(3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine

3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine; 3-chloroimipramine; G 34586; chlorimipramine; monochlorimipramine

3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine

3-(3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine hydrochloride

3-(3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-aminehydrochloride

3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-aminium chloride; 3-chloroimipramine hydrochloride; chloroimipramine monohydrochloride; clomipramine HCl; clomipramine monohydrochloride

3-chloro-10,11-dihydro-N,N-dimethyl-5H-Dibenz(b,f)azepine-5-propanamine

3-Chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine

3-Chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine monohydrochloride; 3-Chloroimipramine hydrochloride; 3-chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine monohydrochloride; 5H-Dibenz(b,f)azepine, 10,11-dihydro-

3-Chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine; 3-Chloroimipramine; 5H-Dibenz(b,f)azepine, 10,11-dihydro-3-chloro-5-(3-(dimethylamino)propyl)-; 5H-Dibenz(b,f)azepine, 3-chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro-; 5H-Dibenz

3-Chloro-5-(3-(Dimethylamino)Propyl)-10,11-Dihydro-5H-Dibenz[B,F]Azepine Hydrochloride

3-Chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine

3-chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro-5h-dibenz[b,f]azepine monohydrochloride

3-Chloroimipramine

3-Chloroimipramine;Chlorimipramine;Clomipramina [INN-Spanish];Clomipraminum [INN-Latin];Monochlorimipramine

303-49-1

303-49-1; Anafranil (TN); Clomipramine (INN); D07727

303-49-1; C06918; Clomipramine

5-20-08-00103 (Beilstein Handbook Reference)

5H-Dibenz(b,f)azepine, 10,11-dihydro-3-chloro-5-(3-(dimethylamino)propyl)-

5H-Dibenz(b,f)azepine, 3-chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro-

5H-Dibenz(b,f)azepine, 3-chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro- (8CI)

5H-Dibenz(b,f)azepine-5-propanamine, 3-chloro-10,11-dihydro-N,N-dimethyl-

5H-Dibenz[b,f]azepine, 10,11-dihydro-3-chloro-5-[3-(dimethylamino)propyl]-

5H-Dibenz[b,f]azepine, 3-chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro-

5H-Dibenz[b,f]azepine-5-propanamine, 3-chloro-10,11-dihydro-N,N-dimethyl-

83162-38-3

AB00053695

AC1L1EHZ

AKOS001487687

Anafranil

Anafranil (free base)

Anafranil (TN)

Anafranil base

BIDD:PXR0151

Biomol-NT_000151

BPBio1_000130

BPBio1_000661

BRD-K52989797-001-01-1

BRD-K52989797-003-05-8

BRN 1323477

BSPBio_000118

BSPBio_003294

C06918

C14H12ClN.C6H15N

C19H23ClN2.HCl; Clomipramine Hydrochloride; LS-173091

CAS-17321-77-6

CHEBI:100996

CHEBI:47359; CHEBI:3754

CHEBI:47780

CHEMBL415

Chlomipramine

Chlomipramine Hydrochloride

Chlorimipramine

Chlorimipramine hydrochloride

CID2801

Clomicalm

Clomipramina

Clomipramina [INN-Spanish]

Clomipramine

Clomipramine (BAN

Clomipramine (hydrochloride)

Clomipramine (INN)

Clomipramine HCl

Clomipramine hydrochloride (Anafranil)

Clomipramine Hydrochloride (FDA

Clomipramine [INN:BAN]

clomipramine(1+)

Clomipramine, HCl

Clomipraminehydrochloride

Clomipraminum

Clomipraminum [INN-Latin]

CPD000058295; Clomipramine hydrochloride; SAM002264601

D07727

DAP000742

DB01242

DB07600

DivK1c_000797

EINECS 206-144-2

G 34586

G-34586

Hydiphen

IDI1_000797

INN)

INN); Clomipramine HCl (FDA

JAN

KBio1_000797

KBio2_000924

KBio2_003492

KBio2_006060

KBio3_002514

KBioGR_000759

KBioSS_000924

L000890

LS-194213

LS-60386

MFCD00069234

MolPort-002-051-949

Monochlorimipramine

N-[3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]-N,N-di methylamine hydrochloride

NCGC00015264-01

NCGC00015264-02

NCGC00015264-03

NCGC00015264-09

NCGC00024355-02

NCGC00024355-04

NCGC00024355-05

NINDS_000797

NSC 169865

NSC169865

Oprea1_312582

PDSP1_000241

PDSP2_000240

Prestwick0_000269

Prestwick1_000269

Prestwick2_000269

Prestwick3_000269

SPBio_001778

SPBio_002337

Spectrum2_001729

Spectrum3_001707

Spectrum4_000350

Spectrum5_001235

Spectrum_000444

STK534842

STOCK2S-26559

Tocris-0457

UNII-NUV44L116D

USAN

USAN)

USP

USP)

USP); Clomipramine (BAN

VR-776

WLN: T C676 BN & T & J B3N1 & 1 EG

Download: MOL2 SDF SMILES Flexibase

Annotations

Vendors

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 4.82 13 -36.13 1 2 1 8 315.868 4 ↓

Vendor Notes

Note Type Comments Provided By
ALOGPS_SOLUBILITY 1.44e-02 g/l DrugBank-approved
Target 5-HT Receptor Selleck Chemicals
Purity 95% Fluorochem
Indications antidepressant KeyOrganics Bioactives
Patent Database Links EP1438962; EP1671628; EP1754712; EP1782813; EP1815846; EP1829527; EP1829528; EP1829534; EP1844769; EP1852111; EP1867641; EP1946777; EP1990639; US2004142904; US2004171682; US2004254182; US2005070552; US2005281845; US2006135511; US2006148790; US2006258715 ChEBI
PUBCHEM_SUBSTANCE_COMMENT NCC_SAMPLE_SUPPLIER : LightBiologicals; NCC_SUPPLIER_STRUCTURE_ID : C-4250; 1 hydrogen chloride NIH Clinical Collection via PubChem
PUBCHEM_SUBSTANCE_COMMENT SAMPLE_SUPPLIER: LightBiologicals; SUPPLIER_STRUCTURE_ID: C-4250; SALT: 1 hydrogen chloride NIH Clinical Collection via PubChem
Therapy Serotonin reuptake inhibitor; antidepressant SMDC Iconix

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
5HT1A-1-E Serotonin 1a (5-HT1a) Receptor (cluster #1 Of 4), Eukaryotic Eukaryotes 5000 0.34 Binding ≤ 10μM
5HT1B-1-E Serotonin 1b (5-HT1b) Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 5000 0.34 Binding ≤ 10μM
5HT1D-1-E Serotonin 1d (5-HT1d) Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 5000 0.34 Binding ≤ 10μM
5HT1F-1-E Serotonin 1f (5-HT1f) Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 5000 0.34 Binding ≤ 10μM
5HT2A-1-E Serotonin 2a (5-HT2a) Receptor (cluster #1 Of 3), Eukaryotic Eukaryotes 8 0.52 Binding ≤ 10μM
5HT2B-1-E Serotonin 2b (5-HT2b) Receptor (cluster #1 Of 4), Eukaryotic Eukaryotes 8 0.52 Binding ≤ 10μM
5HT2C-1-E Serotonin 2c (5-HT2c) Receptor (cluster #1 Of 3), Eukaryotic Eukaryotes 8 0.52 Binding ≤ 10μM
5HT4R-1-E Serotonin 4 (5-HT4) Receptor (cluster #1 Of 1), Eukaryotic Eukaryotes 5 0.53 Binding ≤ 10μM
5HT5A-1-E Serotonin 5a (5-HT5a) Receptor (cluster #1 Of 1), Eukaryotic Eukaryotes 5 0.53 Binding ≤ 10μM
5HT5B-1-E Serotonin 5b (5-HT5b) Receptor (cluster #1 Of 1), Eukaryotic Eukaryotes 5 0.53 Binding ≤ 10μM
5HT6R-1-E Serotonin 6 (5-HT6) Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 5 0.53 Binding ≤ 10μM
5HT7R-1-E Serotonin 7 (5-HT7) Receptor (cluster #1 Of 3), Eukaryotic Eukaryotes 5 0.53 Binding ≤ 10μM
ADA1A-2-E Alpha-1a Adrenergic Receptor (cluster #2 Of 3), Eukaryotic Eukaryotes 46 0.47 Binding ≤ 10μM
ADA1B-1-E Alpha-1b Adrenergic Receptor (cluster #1 Of 4), Eukaryotic Eukaryotes 46 0.47 Binding ≤ 10μM
ADA1D-2-E Alpha-1d Adrenergic Receptor (cluster #2 Of 3), Eukaryotic Eukaryotes 46 0.47 Binding ≤ 10μM
ADA2A-2-E Alpha-2a Adrenergic Receptor (cluster #2 Of 4), Eukaryotic Eukaryotes 51 0.46 Binding ≤ 10μM
ADA2B-1-E Alpha-2b Adrenergic Receptor (cluster #1 Of 4), Eukaryotic Eukaryotes 51 0.46 Binding ≤ 10μM
ADA2C-2-E Alpha-2c Adrenergic Receptor (cluster #2 Of 4), Eukaryotic Eukaryotes 51 0.46 Binding ≤ 10μM
ADCY1-1-E Brain Adenylate Cyclase 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 55 0.46 Binding ≤ 10μM
ADCY2-2-E Adenylate Cyclase Type II (cluster #2 Of 2), Eukaryotic Eukaryotes 55 0.46 Binding ≤ 10μM
ADCY8-1-E Adenylate Cyclase Type VIII (cluster #1 Of 2), Eukaryotic Eukaryotes 55 0.46 Binding ≤ 10μM
ADRB1-1-E Beta-1 Adrenergic Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 46 0.47 Binding ≤ 10μM
ADRB2-1-E Beta-2 Adrenergic Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 46 0.47 Binding ≤ 10μM
ADRB3-1-E Beta-3 Adrenergic Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 46 0.47 Binding ≤ 10μM
HRH1-2-E Histamine H1 Receptor (cluster #2 Of 2), Eukaryotic Eukaryotes 0 0.00 Binding ≤ 10μM
SCN1A-1-E Sodium Channel Protein Type I Alpha Subunit (cluster #1 Of 2), Eukaryotic Eukaryotes 10000 0.32 Binding ≤ 10μM
SCN2A-1-E Sodium Channel Protein Type II Alpha Subunit (cluster #1 Of 2), Eukaryotic Eukaryotes 10000 0.32 Binding ≤ 10μM
SCN3A-1-E Sodium Channel Protein Type III Alpha Subunit (cluster #1 Of 2), Eukaryotic Eukaryotes 10000 0.32 Binding ≤ 10μM
SCN8A-1-E Sodium Channel Protein Type VIII Alpha Subunit (cluster #1 Of 2), Eukaryotic Eukaryotes 10000 0.32 Binding ≤ 10μM
TYTR-1-E Trypanothione Reductase (cluster #1 Of 2), Eukaryotic Eukaryotes 7000 0.33 Binding ≤ 10μM
ADCY1-1-E Brain Adenylate Cyclase 1 (cluster #1 Of 2), Eukaryotic Eukaryotes 4400 0.34 Functional ≤ 10μM
ADCY2-1-E Adenylate Cyclase Type II (cluster #1 Of 1), Eukaryotic Eukaryotes 4400 0.34 Functional ≤ 10μM
ADCY8-1-E Adenylate Cyclase Type VIII (cluster #1 Of 1), Eukaryotic Eukaryotes 4400 0.34 Functional ≤ 10μM
HRH2-1-E Histamine H2 Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 720 0.39 Functional ≤ 10μM
Q9WTR4-1-E Norepinephrine Transporter (cluster #1 Of 2), Eukaryotic Eukaryotes 900 0.38 Functional ≤ 10μM
SC6A3-1-E Dopamine Transporter (cluster #1 Of 1), Eukaryotic Eukaryotes 1000 0.38 Functional ≤ 10μM
SC6A4-1-E Serotonin Transporter (cluster #1 Of 1), Eukaryotic Eukaryotes 90 0.45 Functional ≤ 10μM
DRD2-14-E Dopamine D2 Receptor (cluster #14 Of 24), Eukaryotic Eukaryotes 56 0.46 Binding ≤ 10μM
Z104304-1-O Adrenergic Receptor Alpha-1 (cluster #1 Of 3), Other Other 75 0.45 Binding ≤ 10μM
Z50425-3-O Plasmodium Falciparum (cluster #3 Of 22), Other Other 5012 0.34 Functional ≤ 10μM
Z50466-1-O Trypanosoma Cruzi (cluster #1 Of 8), Other Other 8000 0.32 Functional ≤ 10μM
Z50597-1-O Rattus Norvegicus (cluster #1 Of 12), Other Other 9500 0.32 Functional ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
ADCY2_HUMAN Q08462 Adenylate Cyclase Type II, Human 43 0.47 Binding ≤ 1μM
ADCY8_HUMAN P40145 Adenylate Cyclase Type VIII, Human 43 0.47 Binding ≤ 1μM
Z104304 Z104304 Adrenergic Receptor Alpha-1 75 0.45 Binding ≤ 1μM
ADA1A_RAT P43140 Alpha-1a Adrenergic Receptor, Rat 0.1 0.64 Binding ≤ 1μM
ADA1B_RAT P15823 Alpha-1b Adrenergic Receptor, Rat 46 0.47 Binding ≤ 1μM
ADA1D_RAT P23944 Alpha-1d Adrenergic Receptor, Rat 46 0.47 Binding ≤ 1μM
ADA2A_RAT P22909 Alpha-2a Adrenergic Receptor, Rat 46 0.47 Binding ≤ 1μM
ADA2B_RAT P19328 Alpha-2b Adrenergic Receptor, Rat 46 0.47 Binding ≤ 1μM
ADA2C_RAT P22086 Alpha-2c Adrenergic Receptor, Rat 46 0.47 Binding ≤ 1μM
ADRB1_RAT P18090 Beta-1 Adrenergic Receptor, Rat 46 0.47 Binding ≤ 1μM
ADRB2_RAT P10608 Beta-2 Adrenergic Receptor, Rat 46 0.47 Binding ≤ 1μM
ADRB3_RAT P26255 Beta-3 Adrenergic Receptor, Rat 46 0.47 Binding ≤ 1μM
ADCY1_HUMAN Q08828 Brain Adenylate Cyclase 1, Human 43 0.47 Binding ≤ 1μM
DRD2_RAT P61169 Dopamine D2 Receptor, Rat 56 0.46 Binding ≤ 1μM
HRH1_RAT P31390 Histamine H1 Receptor, Rat 0.2 0.62 Binding ≤ 1μM
5HT1A_RAT P19327 Serotonin 1a (5-HT1a) Receptor, Rat 5 0.53 Binding ≤ 1μM
5HT1B_RAT P28564 Serotonin 1b (5-HT1b) Receptor, Rat 5 0.53 Binding ≤ 1μM
5HT1D_RAT P28565 Serotonin 1d (5-HT1d) Receptor, Rat 5 0.53 Binding ≤ 1μM
5HT1F_RAT P30940 Serotonin 1f (5-HT1f) Receptor, Rat 5 0.53 Binding ≤ 1μM
5HT2A_RAT P14842 Serotonin 2a (5-HT2a) Receptor, Rat 5 0.53 Binding ≤ 1μM
5HT2B_RAT P30994 Serotonin 2b (5-HT2b) Receptor, Rat 5 0.53 Binding ≤ 1μM
5HT2C_RAT P08909 Serotonin 2c (5-HT2c) Receptor, Rat 5 0.53 Binding ≤ 1μM
5HT4R_RAT Q62758 Serotonin 4 (5-HT4) Receptor, Rat 5 0.53 Binding ≤ 1μM
5HT5A_RAT P35364 Serotonin 5a (5-HT5a) Receptor, Rat 5 0.53 Binding ≤ 1μM
5HT5B_RAT P35365 Serotonin 5b (5-HT5b) Receptor, Rat 5 0.53 Binding ≤ 1μM
5HT6R_RAT P31388 Serotonin 6 (5-HT6) Receptor, Rat 5 0.53 Binding ≤ 1μM
5HT7R_RAT P32305 Serotonin 7 (5-HT7) Receptor, Rat 5 0.53 Binding ≤ 1μM
ADCY2_HUMAN Q08462 Adenylate Cyclase Type II, Human 43 0.47 Binding ≤ 10μM
ADCY8_HUMAN P40145 Adenylate Cyclase Type VIII, Human 43 0.47 Binding ≤ 10μM
Z104304 Z104304 Adrenergic Receptor Alpha-1 75 0.45 Binding ≤ 10μM
ADA1A_RAT P43140 Alpha-1a Adrenergic Receptor, Rat 0.1 0.64 Binding ≤ 10μM
ADA1B_RAT P15823 Alpha-1b Adrenergic Receptor, Rat 46 0.47 Binding ≤ 10μM
ADA1D_RAT P23944 Alpha-1d Adrenergic Receptor, Rat 46 0.47 Binding ≤ 10μM
ADA2A_RAT P22909 Alpha-2a Adrenergic Receptor, Rat 46 0.47 Binding ≤ 10μM
ADA2B_RAT P19328 Alpha-2b Adrenergic Receptor, Rat 46 0.47 Binding ≤ 10μM
ADA2C_RAT P22086 Alpha-2c Adrenergic Receptor, Rat 46 0.47 Binding ≤ 10μM
ADRB1_RAT P18090 Beta-1 Adrenergic Receptor, Rat 46 0.47 Binding ≤ 10μM
ADRB2_RAT P10608 Beta-2 Adrenergic Receptor, Rat 46 0.47 Binding ≤ 10μM
ADRB3_RAT P26255 Beta-3 Adrenergic Receptor, Rat 46 0.47 Binding ≤ 10μM
ADCY1_HUMAN Q08828 Brain Adenylate Cyclase 1, Human 43 0.47 Binding ≤ 10μM
DRD2_RAT P61169 Dopamine D2 Receptor, Rat 56 0.46 Binding ≤ 10μM
HRH1_RAT P31390 Histamine H1 Receptor, Rat 0.2 0.62 Binding ≤ 10μM
5HT1A_RAT P19327 Serotonin 1a (5-HT1a) Receptor, Rat 5 0.53 Binding ≤ 10μM
5HT1B_RAT P28564 Serotonin 1b (5-HT1b) Receptor, Rat 5 0.53 Binding ≤ 10μM
5HT1D_RAT P28565 Serotonin 1d (5-HT1d) Receptor, Rat 5 0.53 Binding ≤ 10μM
5HT1F_RAT P30940 Serotonin 1f (5-HT1f) Receptor, Rat 5 0.53 Binding ≤ 10μM
5HT2A_RAT P14842 Serotonin 2a (5-HT2a) Receptor, Rat 5 0.53 Binding ≤ 10μM
5HT2B_RAT P30994 Serotonin 2b (5-HT2b) Receptor, Rat 5 0.53 Binding ≤ 10μM
5HT2C_RAT P08909 Serotonin 2c (5-HT2c) Receptor, Rat 5 0.53 Binding ≤ 10μM
5HT4R_RAT Q62758 Serotonin 4 (5-HT4) Receptor, Rat 5 0.53 Binding ≤ 10μM
5HT5A_RAT P35364 Serotonin 5a (5-HT5a) Receptor, Rat 5 0.53 Binding ≤ 10μM
5HT5B_RAT P35365 Serotonin 5b (5-HT5b) Receptor, Rat 5 0.53 Binding ≤ 10μM
5HT6R_RAT P31388 Serotonin 6 (5-HT6) Receptor, Rat 5 0.53 Binding ≤ 10μM
5HT7R_RAT P32305 Serotonin 7 (5-HT7) Receptor, Rat 5 0.53 Binding ≤ 10μM
SCN1A_HUMAN P35498 Sodium Channel Protein Type I Alpha Subunit, Human 10000 0.32 Binding ≤ 10μM
SCN2A_HUMAN Q99250 Sodium Channel Protein Type II Alpha Subunit, Human 10000 0.32 Binding ≤ 10μM
SCN3A_HUMAN Q9NY46 Sodium Channel Protein Type III Alpha Subunit, Human 10000 0.32 Binding ≤ 10μM
SCN8A_HUMAN Q9UQD0 Sodium Channel Protein Type VIII Alpha Subunit, Human 10000 0.32 Binding ≤ 10μM
TYTR_TRYCR P28593 Trypanothione Reductase, Trycr 6500 0.33 Binding ≤ 10μM
ADCY2_HUMAN Q08462 Adenylate Cyclase Type II, Human 4400 0.34 Functional ≤ 10μM
ADCY8_HUMAN P40145 Adenylate Cyclase Type VIII, Human 4400 0.34 Functional ≤ 10μM
ADCY1_HUMAN Q08828 Brain Adenylate Cyclase 1, Human 4400 0.34 Functional ≤ 10μM
SC6A3_RAT P23977 Dopamine Transporter, Rat 1000 0.38 Functional ≤ 10μM
HRH2_HUMAN P25021 Histamine H2 Receptor, Human 720 0.39 Functional ≤ 10μM
Q9WTR4_RAT Q9WTR4 Norepinephrine Transporter, Rat 700 0.39 Functional ≤ 10μM
Z50425 Z50425 Plasmodium Falciparum 5011.87234 0.34 Functional ≤ 10μM
Z50597 Z50597 Rattus Norvegicus 750 0.39 Functional ≤ 10μM
SC6A4_RAT P31652 Serotonin Transporter, Rat 20 0.49 Functional ≤ 10μM
SC6A4_HUMAN P31645 Serotonin Transporter, Human 70 0.46 Functional ≤ 10μM
Z50466 Z50466 Trypanosoma Cruzi 8000 0.32 Functional ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description Species
Adenylate cyclase activating pathway
Adenylate cyclase inhibitory pathway
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
Adrenoceptors
CREB phosphorylation through the activation of Adenylate Cyclase
Dopamine clearance from the synaptic cleft
Dopamine receptors
G alpha (12/13) signalling events
G alpha (i) signalling events
G alpha (q) signalling events
G alpha (s) signalling events
G alpha (z) signalling events
Glucagon signaling in metabolic regulation
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Histamine receptors
Interaction between L1 and Ankyrins
Na+/Cl- dependent neurotransmitter transporters
PKA activation
PKA activation in glucagon signalling
Serotonin receptors
Vasopressin regulates renal water homeostasis via Aquaporins

Analogs ( Draw Identity 99% 90% 80% 70% )