| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| December 12th, 2008 | 9 | No |
Popular Name: CGP-34938 CGP-34938
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -2.47 | -3.47 | -59.85 | 4 | 4 | 0 | 88 | 153.118 | 3 | ↓ |
| Hi High (pH 8-9.5) | -2.47 | -4.06 | -40.85 | 3 | 4 | -1 | 86 | 152.11 | 3 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GABR1-1-E | GABA-B Receptor 1 (cluster #1 Of 3), Eukaryotic | Eukaryotes | 77 | 1.11 | Binding ≤ 10μM |
| GABR2-1-E | GABA-B Receptor 2 (cluster #1 Of 3), Eukaryotic | Eukaryotes | 77 | 1.11 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GABR1_RAT | Q9Z0U4 | GABA-B Receptor 1, Rat | 77 | 1.11 | Binding ≤ 1μM |
| GABR1_HUMAN | Q9UBS5 | GABA-B Receptor 1, Human | 29 | 1.17 | Binding ≤ 1μM |
| GABR2_RAT | O88871 | GABA-B Receptor 2, Rat | 77 | 1.11 | Binding ≤ 1μM |
| GABR2_HUMAN | O75899 | GABA-B Receptor 2, Human | 29 | 1.17 | Binding ≤ 1μM |
| GABR1_HUMAN | Q9UBS5 | GABA-B Receptor 1, Human | 29 | 1.17 | Binding ≤ 10μM |
| GABR1_RAT | Q9Z0U4 | GABA-B Receptor 1, Rat | 77 | 1.11 | Binding ≤ 10μM |
| GABR2_RAT | O88871 | GABA-B Receptor 2, Rat | 77 | 1.11 | Binding ≤ 10μM |
| GABR2_HUMAN | O75899 | GABA-B Receptor 2, Human | 29 | 1.17 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activation of G protein gated Potassium channels | |
| Class C/3 (Metabotropic glutamate/pheromone receptors) | |
| G alpha (i) signalling events | |
| GABA B receptor activation | |
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
