UCSF

ZINC22448983

Draw Identity 99% 90% 80% 70%

Substance Information

In ZINC since Heavy atoms Benign functionality
December 16th, 2008 36 No

Popular Name: SKI-606 SKI-606

Find On: PubMed — Wikipedia — Google

CAS Number: 380843-75-4

Other Names:

tinib

3-Quinolinecarbonitrile, 4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)-

3-Quinolinecarbonitrile, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-

380443-75-4

380843-75-4

380843-75-4; Bosutinib (USAN); D03252

4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)-3-quinolinecarbonitrile

4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)-3-quinolinecarbonitrile; Bosutinib; SKI 606; SKI-606

4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile

4-(2,4-dichloro-5-methoxyanilino)-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile

4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propo

4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile

4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile monohydrate; Bosutinib monohydrate; SKI-606 monohydrate; bosutinib.H2O

AC-2413

AC1NS5P1

Bosulif

Bosulif (TN); Bosutinib hydrate (JAN); Bosutinib monohydrate; D09728

Bosulif®

Bosutinib

Bosutinib (INN

Bosutinib (USAN)

Bosutinib (USAN); Bosutinib Monohydrate (FDA)

bosutinib hydrate

Bosutinib Monohydrate

Bosutinib Monohydrate (FDA); Bosutinib (INN

C471992

CHEBI:39112

CHEMBL288441

CID5328940

D03252

DCL000369

EC-000.2261

I14-1974

K00615a

PF-5208763

SKI 606

SKI606

ST51054132

UNII-5018V4AEZ0

USAN)

USAN); Bosutinib Monohydrate (FDA)

xy]-3-quinolinecarbonitrile

Download: MOL2 SDF SMILES Flexibase

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 4.98 9.49 -44.8 2 8 1 84 531.464 9 ↓
Hi High (pH 8-9.5) 4.98 7.02 -12.44 1 8 0 83 530.456 9 ↓
Mid Mid (pH 6-8) 4.98 9.35 -46.97 2 8 1 84 531.464 9 ↓

Vendor Notes

Note Type Comments Provided By
ALOGPS_SOLUBILITY 9.50e-03 g/l DrugBank-approved
Patent Database Links US2005101780; WO2007116025 ChEBI

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
ABL1-1-E Tyrosine-protein Kinase ABL (cluster #1 Of 1), Eukaryotic Eukaryotes 20 0.30 Binding ≤ 10μM
ABL2-1-E Tyrosine-protein Kinase ABL2 (cluster #1 Of 1), Eukaryotic Eukaryotes 1 0.35 Binding ≤ 10μM
ACK1-1-E Tyrosine Kinase Non-receptor Protein 2 (cluster #1 Of 1), Eukaryotic Eukaryotes 3 0.33 Binding ≤ 10μM
ALK-1-E ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic Eukaryotes 200 0.26 Binding ≤ 10μM
BCR-1-E Breakpoint Cluster Region Protein (cluster #1 Of 1), Eukaryotic Eukaryotes 20 0.30 Binding ≤ 10μM
BLK-1-E Tyrosine-protein Kinase BLK (cluster #1 Of 1), Eukaryotic Eukaryotes 7 0.32 Binding ≤ 10μM
BMX-1-E Tyrosine-protein Kinase BMX (cluster #1 Of 1), Eukaryotic Eukaryotes 8 0.31 Binding ≤ 10μM
BTK-1-E Tyrosine-protein Kinase BTK (cluster #1 Of 1), Eukaryotic Eukaryotes 3 0.33 Binding ≤ 10μM
CSK-1-E Tyrosine-protein Kinase CSK (cluster #1 Of 1), Eukaryotic Eukaryotes 63 0.28 Binding ≤ 10μM
EGFR-1-E Epidermal Growth Factor Receptor ErbB1 (cluster #1 Of 4), Eukaryotic Eukaryotes 53 0.28 Binding ≤ 10μM
EPHB2-1-E Ephrin Type-B Receptor 2 (cluster #1 Of 1), Eukaryotic Eukaryotes 9 0.31 Binding ≤ 10μM
EPHB4-1-E Ephrin Type-B Receptor 4 (cluster #1 Of 1), Eukaryotic Eukaryotes 6 0.32 Binding ≤ 10μM
FAK1-1-E Focal Adhesion Kinase 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 538 0.24 Binding ≤ 10μM
FAK2-1-E Protein-tyrosine Kinase 2-beta (cluster #1 Of 1), Eukaryotic Eukaryotes 134 0.27 Binding ≤ 10μM
FER-1-E Tyrosine-protein Kinase FER (cluster #1 Of 1), Eukaryotic Eukaryotes 490 0.25 Binding ≤ 10μM
FES-1-E Tyrosine-protein Kinase FES (cluster #1 Of 1), Eukaryotic Eukaryotes 358 0.25 Binding ≤ 10μM
FGR-1-E Tyrosine-protein Kinase FGR (cluster #1 Of 2), Eukaryotic Eukaryotes 1 0.35 Binding ≤ 10μM
FRK-1-E Tyrosine-protein Kinase FRK (cluster #1 Of 1), Eukaryotic Eukaryotes 2 0.34 Binding ≤ 10μM
FYN-1-E Tyrosine-protein Kinase FYN (cluster #1 Of 5), Eukaryotic Eukaryotes 2 0.34 Binding ≤ 10μM
HCK-1-E Tyrosine-protein Kinase HCK (cluster #1 Of 1), Eukaryotic Eukaryotes 3 0.33 Binding ≤ 10μM
IRAK4-1-E Interleukin-1 Receptor-associated Kinase 4 (cluster #1 Of 1), Eukaryotic Eukaryotes 574 0.24 Binding ≤ 10μM
KCC1D-1-E CaM Kinase I Delta (cluster #1 Of 2), Eukaryotic Eukaryotes 92 0.27 Binding ≤ 10μM
KCC2G-1-E CaM Kinase II Gamma (cluster #1 Of 1), Eukaryotic Eukaryotes 184 0.26 Binding ≤ 10μM
KIT-1-E Stem Cell Growth Factor Receptor (cluster #1 Of 1), Eukaryotic Eukaryotes 6313 0.20 Binding ≤ 10μM
KSYK-1-E Tyrosine-protein Kinase SYK (cluster #1 Of 2), Eukaryotic Eukaryotes 52 0.28 Binding ≤ 10μM
LCK-1-E Tyrosine-protein Kinase LCK (cluster #1 Of 4), Eukaryotic Eukaryotes 1 0.35 Binding ≤ 10μM
LYN-1-E Tyrosine-protein Kinase Lyn (cluster #1 Of 1), Eukaryotic Eukaryotes 8 0.31 Binding ≤ 10μM
M4K2-1-E Mitogen-activated Protein Kinase Kinase Kinase Kinase 2 (cluster #1 Of 1), Eukaryotic Eukaryotes 10 0.31 Binding ≤ 10μM
M4K5-1-E Mitogen-activated Protein Kinase Kinase Kinase Kinase 5 (cluster #1 Of 1), Eukaryotic Eukaryotes 0 0.00 Binding ≤ 10μM
MINK1-1-E Misshapen-like Kinase 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 22 0.30 Binding ≤ 10μM
NPM-1-E Nucleophosmin (cluster #1 Of 1), Eukaryotic Eukaryotes 200 0.26 Binding ≤ 10μM
NTRK1-1-E Nerve Growth Factor Receptor Trk-A (cluster #1 Of 1), Eukaryotic Eukaryotes 22 0.30 Binding ≤ 10μM
NTRK2-1-E Neurotrophic Tyrosine Kinase Receptor Type 2 (cluster #1 Of 1), Eukaryotic Eukaryotes 27 0.29 Binding ≤ 10μM
SRC-1-E Tyrosine-protein Kinase SRC (cluster #1 Of 3), Eukaryotic Eukaryotes 4 0.33 Binding ≤ 10μM
STK10-1-E Serine/threonine-protein Kinase 10 (cluster #1 Of 1), Eukaryotic Eukaryotes 52 0.28 Binding ≤ 10μM
STK24-1-E Serine/threonine-protein Kinase 24 (cluster #1 Of 1), Eukaryotic Eukaryotes 4 0.33 Binding ≤ 10μM
STK4-1-E Serine/threonine-protein Kinase MST1 (cluster #1 Of 2), Eukaryotic Eukaryotes 191 0.26 Binding ≤ 10μM
TBK1-1-E Serine/threonine-protein Kinase TBK1 (cluster #1 Of 1), Eukaryotic Eukaryotes 471 0.25 Binding ≤ 10μM
TEC-1-E Tyrosine-protein Kinase TEC (cluster #1 Of 1), Eukaryotic Eukaryotes 282 0.25 Binding ≤ 10μM
TIE2-1-E Tyrosine-protein Kinase TIE-2 (cluster #1 Of 2), Eukaryotic Eukaryotes 1191 0.23 Binding ≤ 10μM
TXK-1-E Tyrosine-protein Kinase TXK (cluster #1 Of 1), Eukaryotic Eukaryotes 40 0.29 Binding ≤ 10μM
UFO-1-E Tyrosine-protein Kinase Receptor UFO (cluster #1 Of 1), Eukaryotic Eukaryotes 174 0.26 Binding ≤ 10μM
YES-1-E Tyrosine-protein Kinase YES (cluster #1 Of 1), Eukaryotic Eukaryotes 0 0.00 Binding ≤ 10μM
ABL1-1-E Tyrosine-protein Kinase ABL (cluster #1 Of 2), Eukaryotic Eukaryotes 490 0.25 Functional ≤ 10μM
ABL2-1-E Tyrosine-protein Kinase ABL2 (cluster #1 Of 1), Eukaryotic Eukaryotes 1 0.35 Functional ≤ 10μM
ERBB2-2-E Receptor Protein-tyrosine Kinase ErbB-2 (cluster #2 Of 3), Eukaryotic Eukaryotes 2600 0.22 Functional ≤ 10μM
FYN-1-E Tyrosine-protein Kinase FYN (cluster #1 Of 1), Eukaryotic Eukaryotes 410 0.25 Functional ≤ 10μM
PGFRA-1-E Platelet-derived Growth Factor Receptor Alpha (cluster #1 Of 1), Eukaryotic Eukaryotes 4000 0.21 Functional ≤ 10μM
PGFRB-1-E Platelet-derived Growth Factor Receptor Beta (cluster #1 Of 1), Eukaryotic Eukaryotes 4000 0.21 Functional ≤ 10μM
SRC-1-E Tyrosine-protein Kinase SRC (cluster #1 Of 1), Eukaryotic Eukaryotes 100 0.27 Functional ≤ 10μM
Z50597-1-O Rattus Norvegicus (cluster #1 Of 12), Other Other 100 0.27 Functional ≤ 10μM
Z80036-2-O BaF3 (IL-3-dependent Pro-B-cells) (cluster #2 Of 3), Other Other 200 0.26 Functional ≤ 10μM
Z80166-1-O HT-29 (Colon Adenocarcinoma Cells) (cluster #1 Of 12), Other Other 5000 0.21 Functional ≤ 10μM
Z80186-6-O K562 (Erythroleukemia Cells) (cluster #6 Of 11), Other Other 20 0.30 Functional ≤ 10μM
Z80416-1-O Rat1 (Fibroblast Cells) (cluster #1 Of 1), Other Other 490 0.25 Functional ≤ 10μM
Z81020-7-O HepG2 (Hepatoblastoma Cells) (cluster #7 Of 8), Other Other 3910 0.21 Functional ≤ 10μM
Z81125-1-O KU812 Cell Line (cluster #1 Of 1), Other Other 5 0.32 Functional ≤ 10μM
Z81328-1-O Src-transformed (Fibroblast Cells) (cluster #1 Of 1), Other Other 100 0.27 Functional ≤ 10μM
ABL-1-V Tyrosine-protein Kinase V-ABL (cluster #1 Of 1), Viral Viruses 1 0.35 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
ALK_HUMAN Q9UM73 ALK Tyrosine Kinase Receptor, Human 150 0.27 Binding ≤ 1μM
BCR_HUMAN P11274 Breakpoint Cluster Region Protein, Human 20 0.30 Binding ≤ 1μM
KCC1D_HUMAN Q8IU85 CaM Kinase I Delta, Human 92 0.27 Binding ≤ 1μM
KCC2G_HUMAN Q13555 CaM Kinase II Gamma, Human 184 0.26 Binding ≤ 1μM
EPHB2_HUMAN P29323 Ephrin Type-B Receptor 2, Human 8.5 0.31 Binding ≤ 1μM
EPHB4_HUMAN P54760 Ephrin Type-B Receptor 4, Human 5.5 0.32 Binding ≤ 1μM
EGFR_HUMAN P00533 Epidermal Growth Factor Receptor ErbB1, Human 53 0.28 Binding ≤ 1μM
FAK1_HUMAN Q05397 Focal Adhesion Kinase 1, Human 538 0.24 Binding ≤ 1μM
IRAK4_HUMAN Q9NWZ3 Interleukin-1 Receptor-associated Kinase 4, Human 574 0.24 Binding ≤ 1μM
MINK1_HUMAN Q8N4C8 Misshapen-like Kinase 1, Human 22 0.30 Binding ≤ 1μM
M4K2_HUMAN Q12851 Mitogen-activated Protein Kinase Kinase Kinase Kinase 2, Human 9.9 0.31 Binding ≤ 1μM
M4K5_HUMAN Q9Y4K4 Mitogen-activated Protein Kinase Kinase Kinase Kinase 5, Human 0.3 0.37 Binding ≤ 1μM
NTRK1_HUMAN P04629 Nerve Growth Factor Receptor Trk-A, Human 22 0.30 Binding ≤ 1μM
NTRK2_HUMAN Q16620 Neurotrophic Tyrosine Kinase Receptor Type 2, Human 27 0.29 Binding ≤ 1μM
NPM_HUMAN P06748 Nucleophosmin, Human 150 0.27 Binding ≤ 1μM
FAK2_HUMAN Q14289 Protein Tyrosine Kinase 2 Beta, Human 134 0.27 Binding ≤ 1μM
STK10_HUMAN O94804 Serine/threonine-protein Kinase 10, Human 52 0.28 Binding ≤ 1μM
STK24_HUMAN Q9Y6E0 Serine/threonine-protein Kinase 24, Human 3.9 0.33 Binding ≤ 1μM
STK4_HUMAN Q13043 Serine/threonine-protein Kinase MST1, Human 191 0.26 Binding ≤ 1μM
TBK1_HUMAN Q9UHD2 Serine/threonine-protein Kinase TBK1, Human 471 0.25 Binding ≤ 1μM
ACK1_HUMAN Q07912 Tyrosine Kinase Non-receptor Protein 2, Human 2.7 0.33 Binding ≤ 1μM
ABL1_HUMAN P00519 Tyrosine-protein Kinase ABL, Human 0.5 0.36 Binding ≤ 1μM
ABL2_MOUSE Q4JIM5 Tyrosine-protein Kinase ABL2, Mouse 1.1 0.35 Binding ≤ 1μM
ABL2_HUMAN P42684 Tyrosine-protein Kinase ABL2, Human 0.5 0.36 Binding ≤ 1μM
BLK_MOUSE P16277 Tyrosine-protein Kinase BLK, Mouse 7.3 0.32 Binding ≤ 1μM
BMX_HUMAN P51813 Tyrosine-protein Kinase BMX, Human 7.9 0.32 Binding ≤ 1μM
BTK_HUMAN Q06187 Tyrosine-protein Kinase BTK, Human 2.5 0.33 Binding ≤ 1μM
CSK_HUMAN P41240 Tyrosine-protein Kinase CSK, Human 63 0.28 Binding ≤ 1μM
FER_HUMAN P16591 Tyrosine-protein Kinase FER, Human 490 0.25 Binding ≤ 1μM
FES_HUMAN P07332 Tyrosine-protein Kinase FES, Human 358 0.25 Binding ≤ 1μM
FGR_HUMAN P09769 Tyrosine-protein Kinase FGR, Human 1.1 0.35 Binding ≤ 1μM
FRK_HUMAN P42685 Tyrosine-protein Kinase FRK, Human 2.2 0.34 Binding ≤ 1μM
FYN_HUMAN P06241 Tyrosine-protein Kinase FYN, Human 1.8 0.34 Binding ≤ 1μM
HCK_HUMAN P08631 Tyrosine-protein Kinase HCK, Human 3.2 0.33 Binding ≤ 1μM
LCK_HUMAN P06239 Tyrosine-protein Kinase LCK, Human 1.3 0.35 Binding ≤ 1μM
LYN_HUMAN P07948 Tyrosine-protein Kinase Lyn, Human 8 0.31 Binding ≤ 1μM
UFO_HUMAN P30530 Tyrosine-protein Kinase Receptor UFO, Human 174 0.26 Binding ≤ 1μM
SRC_HUMAN P12931 Tyrosine-protein Kinase SRC, Human 1 0.35 Binding ≤ 1μM
KSYK_HUMAN P43405 Tyrosine-protein Kinase SYK, Human 52 0.28 Binding ≤ 1μM
TEC_HUMAN P42680 Tyrosine-protein Kinase TEC, Human 282 0.25 Binding ≤ 1μM
TXK_HUMAN P42681 Tyrosine-protein Kinase TXK, Human 40 0.29 Binding ≤ 1μM
ABL_MLVAB P00521 Tyrosine-protein Kinase V-ABL, Mlvab 1.1 0.35 Binding ≤ 1μM
YES_HUMAN P07947 Tyrosine-protein Kinase YES, Human 0.4 0.37 Binding ≤ 1μM
ALK_HUMAN Q9UM73 ALK Tyrosine Kinase Receptor, Human 150 0.27 Binding ≤ 10μM
BCR_HUMAN P11274 Breakpoint Cluster Region Protein, Human 20 0.30 Binding ≤ 10μM
KCC1D_HUMAN Q8IU85 CaM Kinase I Delta, Human 92 0.27 Binding ≤ 10μM
KCC2G_HUMAN Q13555 CaM Kinase II Gamma, Human 184 0.26 Binding ≤ 10μM
EPHB2_HUMAN P29323 Ephrin Type-B Receptor 2, Human 8.5 0.31 Binding ≤ 10μM
EPHB4_HUMAN P54760 Ephrin Type-B Receptor 4, Human 5.5 0.32 Binding ≤ 10μM
EGFR_HUMAN P00533 Epidermal Growth Factor Receptor ErbB1, Human 53 0.28 Binding ≤ 10μM
FAK1_HUMAN Q05397 Focal Adhesion Kinase 1, Human 538 0.24 Binding ≤ 10μM
IRAK4_HUMAN Q9NWZ3 Interleukin-1 Receptor-associated Kinase 4, Human 574 0.24 Binding ≤ 10μM
MINK1_HUMAN Q8N4C8 Misshapen-like Kinase 1, Human 22 0.30 Binding ≤ 10μM
M4K2_HUMAN Q12851 Mitogen-activated Protein Kinase Kinase Kinase Kinase 2, Human 9.9 0.31 Binding ≤ 10μM
M4K5_HUMAN Q9Y4K4 Mitogen-activated Protein Kinase Kinase Kinase Kinase 5, Human 0.3 0.37 Binding ≤ 10μM
NTRK1_HUMAN P04629 Nerve Growth Factor Receptor Trk-A, Human 22 0.30 Binding ≤ 10μM
NTRK2_HUMAN Q16620 Neurotrophic Tyrosine Kinase Receptor Type 2, Human 27 0.29 Binding ≤ 10μM
NPM_HUMAN P06748 Nucleophosmin, Human 150 0.27 Binding ≤ 10μM
FAK2_HUMAN Q14289 Protein Tyrosine Kinase 2 Beta, Human 134 0.27 Binding ≤ 10μM
STK10_HUMAN O94804 Serine/threonine-protein Kinase 10, Human 52 0.28 Binding ≤ 10μM
STK24_HUMAN Q9Y6E0 Serine/threonine-protein Kinase 24, Human 3.9 0.33 Binding ≤ 10μM
STK4_HUMAN Q13043 Serine/threonine-protein Kinase MST1, Human 191 0.26 Binding ≤ 10μM
TBK1_HUMAN Q9UHD2 Serine/threonine-protein Kinase TBK1, Human 471 0.25 Binding ≤ 10μM
KIT_HUMAN P10721 Stem Cell Growth Factor Receptor, Human 6313 0.20 Binding ≤ 10μM
ACK1_HUMAN Q07912 Tyrosine Kinase Non-receptor Protein 2, Human 2.7 0.33 Binding ≤ 10μM
ABL1_HUMAN P00519 Tyrosine-protein Kinase ABL, Human 0.5 0.36 Binding ≤ 10μM
ABL2_HUMAN P42684 Tyrosine-protein Kinase ABL2, Human 0.5 0.36 Binding ≤ 10μM
ABL2_MOUSE Q4JIM5 Tyrosine-protein Kinase ABL2, Mouse 1.1 0.35 Binding ≤ 10μM
BLK_MOUSE P16277 Tyrosine-protein Kinase BLK, Mouse 7.3 0.32 Binding ≤ 10μM
BMX_HUMAN P51813 Tyrosine-protein Kinase BMX, Human 7.9 0.32 Binding ≤ 10μM
BTK_HUMAN Q06187 Tyrosine-protein Kinase BTK, Human 2.5 0.33 Binding ≤ 10μM
CSK_HUMAN P41240 Tyrosine-protein Kinase CSK, Human 63 0.28 Binding ≤ 10μM
FER_HUMAN P16591 Tyrosine-protein Kinase FER, Human 490 0.25 Binding ≤ 10μM
FES_HUMAN P07332 Tyrosine-protein Kinase FES, Human 358 0.25 Binding ≤ 10μM
FGR_HUMAN P09769 Tyrosine-protein Kinase FGR, Human 1.1 0.35 Binding ≤ 10μM
FRK_HUMAN P42685 Tyrosine-protein Kinase FRK, Human 2.2 0.34 Binding ≤ 10μM
FYN_HUMAN P06241 Tyrosine-protein Kinase FYN, Human 1.8 0.34 Binding ≤ 10μM
HCK_HUMAN P08631 Tyrosine-protein Kinase HCK, Human 3.2 0.33 Binding ≤ 10μM
LCK_HUMAN P06239 Tyrosine-protein Kinase LCK, Human 1.3 0.35 Binding ≤ 10μM
LYN_HUMAN P07948 Tyrosine-protein Kinase Lyn, Human 8 0.31 Binding ≤ 10μM
UFO_HUMAN P30530 Tyrosine-protein Kinase Receptor UFO, Human 174 0.26 Binding ≤ 10μM
SRC_HUMAN P12931 Tyrosine-protein Kinase SRC, Human 1 0.35 Binding ≤ 10μM
KSYK_HUMAN P43405 Tyrosine-protein Kinase SYK, Human 52 0.28 Binding ≤ 10μM
TEC_HUMAN P42680 Tyrosine-protein Kinase TEC, Human 282 0.25 Binding ≤ 10μM
TIE2_HUMAN Q02763 Tyrosine-protein Kinase TIE-2, Human 1191 0.23 Binding ≤ 10μM
TXK_HUMAN P42681 Tyrosine-protein Kinase TXK, Human 40 0.29 Binding ≤ 10μM
ABL_MLVAB P00521 Tyrosine-protein Kinase V-ABL, Mlvab 1.1 0.35 Binding ≤ 10μM
YES_HUMAN P07947 Tyrosine-protein Kinase YES, Human 0.4 0.37 Binding ≤ 10μM
Z80036 Z80036 BaF3 (IL-3-dependent Pro-B-cells) 1000 0.23 Functional ≤ 10μM
Z81020 Z81020 HepG2 (Hepatoblastoma Cells) 3910 0.21 Functional ≤ 10μM
Z80166 Z80166 HT-29 (Colon Adenocarcinoma Cells) 3870 0.21 Functional ≤ 10μM
Z80186 Z80186 K562 (Erythroleukemia Cells) 20 0.30 Functional ≤ 10μM
Z81125 Z81125 KU812 Cell Line 5 0.32 Functional ≤ 10μM
PGFRA_RAT P20786 Platelet-derived Growth Factor Receptor Alpha, Rat 4000 0.21 Functional ≤ 10μM
PGFRB_RAT Q05030 Platelet-derived Growth Factor Receptor Beta, Rat 4000 0.21 Functional ≤ 10μM
Z80416 Z80416 Rat1 (Fibroblast Cells) 100 0.27 Functional ≤ 10μM
Z50597 Z50597 Rattus Norvegicus 100 0.27 Functional ≤ 10μM
ERBB2_HUMAN P04626 Receptor Protein-tyrosine Kinase ErbB-2, Human 2600 0.22 Functional ≤ 10μM
Z81328 Z81328 Src-transformed (Fibroblast Cells) 100 0.27 Functional ≤ 10μM
ABL1_HUMAN P00519 Tyrosine-protein Kinase ABL, Human 1 0.35 Functional ≤ 10μM
ABL2_HUMAN P42684 Tyrosine-protein Kinase ABL2, Human 1 0.35 Functional ≤ 10μM
FYN_HUMAN P06241 Tyrosine-protein Kinase FYN, Human 410 0.25 Functional ≤ 10μM
SRC_HUMAN P12931 Tyrosine-protein Kinase SRC, Human 100 0.27 Functional ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description Species
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Antigen activates B Cell Receptor (BCR) leading to generation of second messenge
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
ARMS-mediated activation
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CDO in myogenesis
Cell surface interactions at the vascular wall
Constitutive PI3K/AKT Signaling in Cancer
CREB phosphorylation through the activation of CaMKII
CREB phosphorylation through the activation of Ras
CRMPs in Sema3A signaling
CTLA4 inhibitory signaling
DAP12 signaling
DCC mediated attractive signaling
Deposition of new CENPA-containing nucleosomes at the centromere
Downregulation of ERBB2:ERBB3 signaling
Downstream signal transduction
Downstream TCR signaling
EGFR downregulation
EGFR interacts with phospholipase C-gamma
EGFR Transactivation by Gastrin
EPH-ephrin mediated repulsion of cells
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPHB-mediated forward signaling
Ephrin signaling
Factors involved in megakaryocyte development and platelet production
Fc epsilon receptor (FCERI) signaling
FCERI mediated Ca+2 mobilization
FCERI mediated MAPK activation
FCERI mediated NF-kB activation
FCGR activation
Frs2-mediated activation
GAB1 signalosome
Generation of second messenger molecules
GPVI-mediated activation cascade
GRB2 events in EGFR signaling
GRB2 events in ERBB2 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
GRB7 events in ERBB2 signaling
Growth hormone receptor signaling
HSF1-dependent transactivation
Integrin alphaIIb beta3 signaling
Interferon gamma signaling
Interleukin-1 signaling
Interleukin-2 signaling
Interleukin-3, 5 and GM-CSF signaling
IRF3 mediated activation of type 1 IFN
IRF3-mediated induction of type I IFN
L1CAM interactions
MyD88 cascade initiated on plasma membrane
MyD88 dependent cascade initiated on endosome
MyD88:Mal cascade initiated on plasma membrane
NCAM signaling for neurite out-growth
Nef and signal transduction
Nef Mediated CD4 Down-regulation
Negative regulators of RIG-I/MDA5 signaling
Nephrin interactions
Netrin mediated repulsion signals
NGF-independant TRKA activation
Nuclear import of Rev protein
Oxidative Stress Induced Senescence
p130Cas linkage to MAPK signaling for integrins
PD-1 signaling
PECAM1 interactions
Phosphorylation of CD3 and TCR zeta chains
PI3K events in ERBB2 signaling
PI3K/AKT activation
PIP3 activates AKT signaling
Platelet Adhesion to exposed collagen
Platelet sensitization by LDL
PLC-gamma1 signalling
PLCG1 events in ERBB2 signaling
Ras activation uopn Ca2+ infux through NMDA receptor
Regulation of actin dynamics for phagocytic cup formation
Regulation of innate immune responses to cytosolic DNA
Regulation of KIT signaling
Regulation of signaling by CBL
Retrograde neurotrophin signalling
Rho GTPase cycle
Role of Abl in Robo-Slit signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Role of phospholipids in phagocytosis
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Sema4D induced cell migration and growth-cone collapse
SHC1 events in EGFR signaling
SHC1 events in ERBB2 signaling
Signal regulatory protein (SIRP) family interactions
Signal transduction by L1
Signaling by constitutively active EGFR
Signaling by EGFR
Signaling by ERBB2
Signaling by ERBB4
Signaling by FGFR1 fusion mutants
Signaling by Hippo
Signaling by PDGF
Signaling by SCF-KIT
Signalling to p38 via RIT and RIN
Signalling to RAS
Signalling to STAT3
STAT6-mediated induction of chemokines
Tie2 Signaling
TRAF3-dependent IRF activation pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
TRAF6 mediated IRF7 activation
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
Trafficking of AMPA receptors
Translocation of ZAP-70 to Immunological synapse
TRKA activation by NGF
Unblocking of NMDA receptor, glutamate binding and activation
VEGFA-VEGFR2 Pathway

Analogs ( Draw Identity 99% 90% 80% 70% )