| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| January 19th, 2009 | 20 | No |
Popular Name: Alpha-hydroxyfarnesylphosphonic acid Alpha-hydroxyfarnesylphosphonic …
Find On: PubMed — Wikipedia — Google
CAS Number: 148796-53-6
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.76 | 4.93 | -45.96 | 2 | 4 | -1 | 81 | 301.343 | 8 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FDFT-3-E | Squalene Synthetase (cluster #3 Of 4), Eukaryotic | Eukaryotes | 2300 | 0.39 | Binding ≤ 10μM |
| FNTA-2-E | Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit (cluster #2 Of 3), Eukaryotic | Eukaryotes | 5 | 0.58 | Binding ≤ 10μM |
| FNTB-2-E | Protein Farnesyltransferase Beta Subunit (cluster #2 Of 3), Eukaryotic | Eukaryotes | 5 | 0.58 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FNTB_HUMAN | P49356 | Protein Farnesyltransferase Beta Subunit, Human | 5.2 | 0.58 | Binding ≤ 1μM |
| FNTB_BOVIN | P49355 | Protein Farnesyltransferase Beta Subunit, Bovin | 410 | 0.45 | Binding ≤ 1μM |
| FNTA_HUMAN | P49354 | Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Human | 5.2 | 0.58 | Binding ≤ 1μM |
| FNTA_BOVIN | P29702 | Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Bovin | 410 | 0.45 | Binding ≤ 1μM |
| FNTB_BOVIN | P49355 | Protein Farnesyltransferase Beta Subunit, Bovin | 410 | 0.45 | Binding ≤ 10μM |
| FNTB_HUMAN | P49356 | Protein Farnesyltransferase Beta Subunit, Human | 5.2 | 0.58 | Binding ≤ 10μM |
| FNTA_HUMAN | P49354 | Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Human | 5.2 | 0.58 | Binding ≤ 10μM |
| FNTA_BOVIN | P29702 | Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Bovin | 410 | 0.45 | Binding ≤ 10μM |
| FDFT_RAT | Q02769 | Squalene Synthetase, Rat | 2300 | 0.39 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activation of gene expression by SREBF (SREBP) | |
| Apoptotic cleavage of cellular proteins | |
| Cholesterol biosynthesis | |
| Inactivation, recovery and regulation of the phototransduction cascade | |
| PPARA activates gene expression |
