| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| February 7th, 2009 | 34 | Yes |
Popular Name: 3-diethylamino-N-[6-(3-diethylaminopropanoylamino)acridin-3-yl]propanamide 3-diethylamino-N-[6-(3-diethylam…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.58 | 11.43 | -95.55 | 4 | 7 | 2 | 80 | 465.642 | 12 | ↓ |
| Lo Low (pH 4.5-6) | 3.58 | 11.79 | -146.81 | 5 | 7 | 3 | 81 | 466.65 | 12 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| TERT-1-E | Telomerase Reverse Transcriptase (cluster #1 Of 2), Eukaryotic | Eukaryotes | 5800 | 0.22 | Binding ≤ 10μM |
| Z80493-3-O | SK-OV-3 (Ovarian Carcinoma Cells) (cluster #3 Of 6), Other | Other | 2250 | 0.23 | Functional ≤ 10μM |
| Z80768-1-O | CH1 (Ovarian Carcinoma Cells) (cluster #1 Of 1), Other | Other | 2450 | 0.23 | Functional ≤ 10μM |
| Z81034-6-O | A2780 (Ovarian Carcinoma Cells) (cluster #6 Of 10), Other | Other | 570 | 0.26 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| TERT_HUMAN | O14746 | Telomerase Reverse Transcriptase, Human | 5800 | 0.22 | Binding ≤ 10μM |
| Z81034 | Z81034 | A2780 (Ovarian Carcinoma Cells) | 570 | 0.26 | Functional ≤ 10μM |
| Z80768 | Z80768 | CH1 (Ovarian Carcinoma Cells) | 2450 | 0.23 | Functional ≤ 10μM |
| Z80493 | Z80493 | SK-OV-3 (Ovarian Carcinoma Cells) | 2250 | 0.23 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| formation of the beta-catenin:TCF transactivating complex | |
| Telomere Extension By Telomerase |
