| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| February 12th, 2009 | 31 | No |
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.69 | 5.99 | -27.59 | 5 | 7 | 0 | 122 | 463.625 | 12 | ↓ |
| Hi High (pH 8-9.5) | 3.69 | 7.22 | -70.68 | 4 | 7 | -1 | 124 | 462.617 | 12 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FCER2-1-E | Immunoglobulin Epsilon Fc Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 30 | 0.34 | Binding ≤ 10μM |
| MMP1-2-E | Matrix Metalloproteinase-1 (cluster #2 Of 2), Eukaryotic | Eukaryotes | 42 | 0.33 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FCER2_HUMAN | P06734 | Immunoglobulin Epsilon Fc Receptor, Human | 30 | 0.34 | Binding ≤ 1μM |
| MMP1_HUMAN | P03956 | Matrix Metalloproteinase-1, Human | 42 | 0.33 | Binding ≤ 1μM |
| FCER2_HUMAN | P06734 | Immunoglobulin Epsilon Fc Receptor, Human | 30 | 0.34 | Binding ≤ 10μM |
| MMP1_HUMAN | P03956 | Matrix Metalloproteinase-1, Human | 42 | 0.33 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activation of Matrix Metalloproteinases | |
| Basigin interactions | |
| Collagen degradation | |
| Degradation of the extracellular matrix | |
| NOTCH2 intracellular domain regulates transcription | |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l |
