| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| March 9th, 2009 | 25 | Yes |
Popular Name: Lck inhibitor 2 Lck inhibitor 2
Find On: PubMed — Wikipedia — Google
CAS Number: 944795-06-6
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.13 | 4.7 | -17.34 | 5 | 7 | 0 | 113 | 335.367 | 5 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| ADCK4-1-E | Uncharacterized AarF Domain-containing Protein Kinase 4 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 129 | 0.39 | Binding ≤ 10μM |
| BLK-1-E | Tyrosine-protein Kinase BLK (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1 | 0.50 | Binding ≤ 10μM |
| BMX-1-E | Tyrosine-protein Kinase BMX (cluster #1 Of 1), Eukaryotic | Eukaryotes | 36 | 0.42 | Binding ≤ 10μM |
| BTK-1-E | Tyrosine-protein Kinase BTK (cluster #1 Of 1), Eukaryotic | Eukaryotes | 9 | 0.45 | Binding ≤ 10μM |
| CSK-1-E | Tyrosine-protein Kinase CSK (cluster #1 Of 1), Eukaryotic | Eukaryotes | 28 | 0.42 | Binding ≤ 10μM |
| EPHA1-1-E | Ephrin Type-A Receptor 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 5 | 0.46 | Binding ≤ 10μM |
| EPHA2-1-E | Ephrin Type-A Receptor 2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 8 | 0.45 | Binding ≤ 10μM |
| EPHA3-1-E | Ephrin Type-A Receptor 3 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 0 | 0.00 | Binding ≤ 10μM |
| EPHA4-1-E | Ephrin Type-A Receptor 4 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 5 | 0.46 | Binding ≤ 10μM |
| EPHA5-1-E | Ephrin Type-A Receptor 5 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3 | 0.48 | Binding ≤ 10μM |
| EPHA6-1-E | Ephrin Type-A Receptor 6 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 20 | 0.43 | Binding ≤ 10μM |
| EPHB2-1-E | Ephrin Type-B Receptor 2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 7 | 0.46 | Binding ≤ 10μM |
| EPHB3-1-E | Ephrin Type-B Receptor 3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 81 | 0.40 | Binding ≤ 10μM |
| FGR-1-E | Tyrosine-protein Kinase FGR (cluster #1 Of 2), Eukaryotic | Eukaryotes | 0 | 0.00 | Binding ≤ 10μM |
| FYN-1-E | Tyrosine-protein Kinase FYN (cluster #1 Of 5), Eukaryotic | Eukaryotes | 0 | 0.00 | Binding ≤ 10μM |
| KSYK-1-E | Tyrosine-protein Kinase SYK (cluster #1 Of 2), Eukaryotic | Eukaryotes | 26 | 0.42 | Binding ≤ 10μM |
| LCK-1-E | Tyrosine-protein Kinase LCK (cluster #1 Of 4), Eukaryotic | Eukaryotes | 13 | 0.44 | Binding ≤ 10μM |
| LYN-1-E | Tyrosine-protein Kinase Lyn (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3 | 0.48 | Binding ≤ 10μM |
| PTK6-1-E | Tyrosine-protein Kinase BRK (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2 | 0.49 | Binding ≤ 10μM |
| TXK-1-E | Tyrosine-protein Kinase TXK (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2 | 0.49 | Binding ≤ 10μM |
| TYRO3-1-E | Tyrosine-protein Kinase Receptor TYRO3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 264 | 0.37 | Binding ≤ 10μM |
| YES-1-E | Tyrosine-protein Kinase YES (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1 | 0.50 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| EPHA1_HUMAN | P21709 | Ephrin Type-A Receptor 1, Human | 5 | 0.46 | Binding ≤ 1μM |
| EPHA2_HUMAN | P29317 | Ephrin Type-A Receptor 2, Human | 8 | 0.45 | Binding ≤ 1μM |
| EPHA3_HUMAN | P29320 | Ephrin Type-A Receptor 3, Human | 0.1 | 0.56 | Binding ≤ 1μM |
| EPHA4_HUMAN | P54764 | Ephrin Type-A Receptor 4, Human | 5 | 0.46 | Binding ≤ 1μM |
| EPHA5_HUMAN | P54756 | Ephrin Type-A Receptor 5, Human | 3 | 0.48 | Binding ≤ 1μM |
| EPHA6_HUMAN | Q9UF33 | Ephrin Type-A Receptor 6, Human | 20 | 0.43 | Binding ≤ 1μM |
| EPHB2_HUMAN | P29323 | Ephrin Type-B Receptor 2, Human | 7 | 0.46 | Binding ≤ 1μM |
| EPHB3_HUMAN | P54753 | Ephrin Type-B Receptor 3, Human | 81 | 0.40 | Binding ≤ 1μM |
| BLK_HUMAN | P51451 | Tyrosine-protein Kinase BLK, Human | 1 | 0.50 | Binding ≤ 1μM |
| BMX_HUMAN | P51813 | Tyrosine-protein Kinase BMX, Human | 36 | 0.42 | Binding ≤ 1μM |
| PTK6_HUMAN | Q13882 | Tyrosine-protein Kinase BRK, Human | 2 | 0.49 | Binding ≤ 1μM |
| BTK_HUMAN | Q06187 | Tyrosine-protein Kinase BTK, Human | 9 | 0.45 | Binding ≤ 1μM |
| CSK_HUMAN | P41240 | Tyrosine-protein Kinase CSK, Human | 28 | 0.42 | Binding ≤ 1μM |
| FGR_HUMAN | P09769 | Tyrosine-protein Kinase FGR, Human | 0.3 | 0.53 | Binding ≤ 1μM |
| FYN_HUMAN | P06241 | Tyrosine-protein Kinase FYN, Human | 0.4 | 0.53 | Binding ≤ 1μM |
| LCK_MOUSE | P06240 | Tyrosine-protein Kinase LCK, Mouse | 13 | 0.44 | Binding ≤ 1μM |
| LCK_HUMAN | P06239 | Tyrosine-protein Kinase LCK, Human | 14 | 0.44 | Binding ≤ 1μM |
| LYN_HUMAN | P07948 | Tyrosine-protein Kinase Lyn, Human | 3 | 0.48 | Binding ≤ 1μM |
| TYRO3_HUMAN | Q06418 | Tyrosine-protein Kinase Receptor TYRO3, Human | 264 | 0.37 | Binding ≤ 1μM |
| KSYK_HUMAN | P43405 | Tyrosine-protein Kinase SYK, Human | 26 | 0.42 | Binding ≤ 1μM |
| TXK_HUMAN | P42681 | Tyrosine-protein Kinase TXK, Human | 10 | 0.45 | Binding ≤ 1μM |
| YES_HUMAN | P07947 | Tyrosine-protein Kinase YES, Human | 1 | 0.50 | Binding ≤ 1μM |
| ADCK4_HUMAN | Q96D53 | Uncharacterized AarF Domain-containing Protein Kinase 4, Human | 129 | 0.39 | Binding ≤ 1μM |
| EPHA1_HUMAN | P21709 | Ephrin Type-A Receptor 1, Human | 5 | 0.46 | Binding ≤ 10μM |
| EPHA2_HUMAN | P29317 | Ephrin Type-A Receptor 2, Human | 8 | 0.45 | Binding ≤ 10μM |
| EPHA3_HUMAN | P29320 | Ephrin Type-A Receptor 3, Human | 0.1 | 0.56 | Binding ≤ 10μM |
| EPHA4_HUMAN | P54764 | Ephrin Type-A Receptor 4, Human | 5 | 0.46 | Binding ≤ 10μM |
| EPHA5_HUMAN | P54756 | Ephrin Type-A Receptor 5, Human | 3 | 0.48 | Binding ≤ 10μM |
| EPHA6_HUMAN | Q9UF33 | Ephrin Type-A Receptor 6, Human | 20 | 0.43 | Binding ≤ 10μM |
| EPHB2_HUMAN | P29323 | Ephrin Type-B Receptor 2, Human | 7 | 0.46 | Binding ≤ 10μM |
| EPHB3_HUMAN | P54753 | Ephrin Type-B Receptor 3, Human | 81 | 0.40 | Binding ≤ 10μM |
| BLK_HUMAN | P51451 | Tyrosine-protein Kinase BLK, Human | 1 | 0.50 | Binding ≤ 10μM |
| BMX_HUMAN | P51813 | Tyrosine-protein Kinase BMX, Human | 36 | 0.42 | Binding ≤ 10μM |
| PTK6_HUMAN | Q13882 | Tyrosine-protein Kinase BRK, Human | 2 | 0.49 | Binding ≤ 10μM |
| BTK_HUMAN | Q06187 | Tyrosine-protein Kinase BTK, Human | 9 | 0.45 | Binding ≤ 10μM |
| CSK_HUMAN | P41240 | Tyrosine-protein Kinase CSK, Human | 28 | 0.42 | Binding ≤ 10μM |
| FGR_HUMAN | P09769 | Tyrosine-protein Kinase FGR, Human | 0.3 | 0.53 | Binding ≤ 10μM |
| FYN_HUMAN | P06241 | Tyrosine-protein Kinase FYN, Human | 0.4 | 0.53 | Binding ≤ 10μM |
| LCK_MOUSE | P06240 | Tyrosine-protein Kinase LCK, Mouse | 13 | 0.44 | Binding ≤ 10μM |
| LCK_HUMAN | P06239 | Tyrosine-protein Kinase LCK, Human | 14 | 0.44 | Binding ≤ 10μM |
| LYN_HUMAN | P07948 | Tyrosine-protein Kinase Lyn, Human | 3 | 0.48 | Binding ≤ 10μM |
| TYRO3_HUMAN | Q06418 | Tyrosine-protein Kinase Receptor TYRO3, Human | 264 | 0.37 | Binding ≤ 10μM |
| KSYK_HUMAN | P43405 | Tyrosine-protein Kinase SYK, Human | 26 | 0.42 | Binding ≤ 10μM |
| TXK_HUMAN | P42681 | Tyrosine-protein Kinase TXK, Human | 10 | 0.45 | Binding ≤ 10μM |
| YES_HUMAN | P07947 | Tyrosine-protein Kinase YES, Human | 1 | 0.50 | Binding ≤ 10μM |
| ADCK4_HUMAN | Q96D53 | Uncharacterized AarF Domain-containing Protein Kinase 4, Human | 129 | 0.39 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Antigen activates B Cell Receptor (BCR) leading to generation of second messenge | |
| Apoptotic cleavage of cellular proteins | |
| CD28 co-stimulation | |
| CD28 dependent PI3K/Akt signaling | |
| CD28 dependent Vav1 pathway | |
| Cell surface interactions at the vascular wall | |
| Constitutive PI3K/AKT Signaling in Cancer | |
| CRMPs in Sema3A signaling | |
| CTLA4 inhibitory signaling | |
| DAP12 signaling | |
| DCC mediated attractive signaling | |
| Downstream TCR signaling | |
| EPH-ephrin mediated repulsion of cells | |
| EPH-Ephrin signaling | |
| EPHA-mediated growth cone collapse | |
| EPHB-mediated forward signaling | |
| Ephrin signaling | |
| Fc epsilon receptor (FCERI) signaling | |
| FCERI mediated Ca+2 mobilization | |
| FCERI mediated MAPK activation | |
| FCERI mediated NF-kB activation | |
| FCGR activation | |
| GAB1 signalosome | |
| Generation of second messenger molecules | |
| GPVI-mediated activation cascade | |
| Growth hormone receptor signaling | |
| Integrin alphaIIb beta3 signaling | |
| Interleukin-2 signaling | |
| L1CAM interactions | |
| MyD88:Mal cascade initiated on plasma membrane | |
| NCAM signaling for neurite out-growth | |
| Nef and signal transduction | |
| Nef Mediated CD4 Down-regulation | |
| Nephrin interactions | |
| Netrin mediated repulsion signals | |
| PD-1 signaling | |
| PECAM1 interactions | |
| Phosphorylation of CD3 and TCR zeta chains | |
| PIP3 activates AKT signaling | |
| Platelet Adhesion to exposed collagen | |
| Platelet sensitization by LDL | |
| POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | |
| Regulation of actin dynamics for phagocytic cup formation | |
| Regulation of KIT signaling | |
| Regulation of signaling by CBL | |
| Role of LAT2/NTAL/LAB on calcium mobilization | |
| Role of phospholipids in phagocytosis | |
| Sema3A PAK dependent Axon repulsion | |
| SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | |
| Signaling by ERBB2 | |
| Signaling by SCF-KIT | |
| Translocation of ZAP-70 to Immunological synapse | |
| VEGFA-VEGFR2 Pathway |
No pre-computed analogs available. Try a structural similarity search.