| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| August 24th, 2009 | 31 | Yes |
Popular Name: (4R,5R)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole (4R,5R)-4,5-bis(4-chlorophenyl)-…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 6.10 | 13.27 | -31.81 | 2 | 4 | 1 | 44 | 456.393 | 6 | ↓ |
| Mid Mid (pH 6-8) | 6.10 | 12.45 | -7.72 | 1 | 4 | 0 | 43 | 455.385 | 6 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| MDM2-1-E | P53-binding Protein Mdm-2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 90 | 0.32 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| MDM2_HUMAN | Q00987 | P53-binding Protein Mdm-2, Human | 90 | 0.32 | Binding ≤ 1μM |
| MDM2_HUMAN | Q00987 | P53-binding Protein Mdm-2, Human | 90 | 0.32 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| AKT phosphorylates targets in the cytosol | |
| Constitutive PI3K/AKT Signaling in Cancer | |
| Oncogene Induced Senescence | |
| Oxidative Stress Induced Senescence | |
| Stabilization of p53 | |
| Trafficking of AMPA receptors |
