| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| September 1st, 2009 | 34 | Yes |
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 2.17 | 12.28 | -44.3 | 0 | 5 | -1 | 79 | 496.502 | 6 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PE2R1-1-E | Prostanoid EP1 Receptor (cluster #1 Of 2), Eukaryotic | Eukaryotes | 4590 | 0.22 | Binding ≤ 10μM |
| PE2R2-1-E | Prostanoid EP2 Receptor (cluster #1 Of 2), Eukaryotic | Eukaryotes | 2270 | 0.23 | Binding ≤ 10μM |
| PE2R3-1-E | Prostanoid EP3 Receptor (cluster #1 Of 3), Eukaryotic | Eukaryotes | 830 | 0.25 | Binding ≤ 10μM |
| PE2R4-1-E | Prostanoid EP4 Receptor (cluster #1 Of 2), Eukaryotic | Eukaryotes | 6610 | 0.21 | Binding ≤ 10μM |
| PF2R-1-E | Prostaglandin F2-alpha Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 4320 | 0.22 | Binding ≤ 10μM |
| PD2R-1-E | Prostanoid DP Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3 | 0.35 | Functional ≤ 10μM |
| TA2R-1-E | Thromboxane A2 Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 338 | 0.27 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PE2R3_HUMAN | P43115 | Prostanoid EP3 Receptor, Human | 830 | 0.25 | Binding ≤ 1μM |
| PE2R1_HUMAN | P34995 | Prostanoid EP1 Receptor, Human | 4590 | 0.22 | Binding ≤ 10μM |
| PE2R2_HUMAN | P43116 | Prostanoid EP2 Receptor, Human | 2270 | 0.23 | Binding ≤ 10μM |
| PE2R3_HUMAN | P43115 | Prostanoid EP3 Receptor, Human | 830 | 0.25 | Binding ≤ 10μM |
| PE2R4_HUMAN | P35408 | Prostanoid EP4 Receptor, Human | 6610 | 0.21 | Binding ≤ 10μM |
| PF2R_HUMAN | P43088 | Prostanoid FP Receptor, Human | 4320 | 0.22 | Binding ≤ 10μM |
| PD2R_HUMAN | Q13258 | Prostanoid DP Receptor, Human | 0.43 | 0.39 | Functional ≤ 10μM |
| TA2R_HUMAN | P21731 | Thromboxane A2 Receptor, Human | 338 | 0.27 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| G alpha (12/13) signalling events | |
| G alpha (i) signalling events | |
| G alpha (q) signalling events | |
| G alpha (s) signalling events | |
| Prostanoid ligand receptors | |
| Thromboxane signalling through TP receptor |
