Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.64	8.77	-18.1	5	7	0	118	493.611	6	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	2.64	9.03	-56.73	6	7	1	120	494.619	6	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	2.64	8.94	-39.2	6	7	1	119	494.619	6	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRD-1-E	Delta Opioid Receptor (cluster #1 Of 3), Eukaryotic	Eukaryotes	24	0.29	Binding ≤ 10μM
OPRM-1-E	Mu-type Opioid Receptor (cluster #1 Of 4), Eukaryotic	Eukaryotes	24	0.29	Binding ≤ 10μM
OPRD-1-E	Delta Opioid Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	22	0.29	Functional ≤ 10μM
OPRM-1-E	Mu Opioid Receptor (cluster #1 Of 2), Eukaryotic	Eukaryotes	161	0.26	Functional ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRD_RAT	P33533	Delta Opioid Receptor, Rat	0.1	0.38	Binding ≤ 1μM
OPRM_RAT	P33535	Mu Opioid Receptor, Rat	1.4	0.34	Binding ≤ 1μM
OPRD_RAT	P33533	Delta Opioid Receptor, Rat	0.1	0.38	Binding ≤ 10μM
OPRM_RAT	P33535	Mu Opioid Receptor, Rat	1.4	0.34	Binding ≤ 10μM
OPRD_MOUSE	P32300	Delta Opioid Receptor, Mouse	22	0.29	Functional ≤ 10μM
OPRM_CAVPO	P97266	Mu Opioid Receptor, Guinea Pig	161	0.26	Functional ≤ 10μM

Description	Species
G alpha (i) signalling events	Mus musculus (OPRD_MOUSE) Rattus norvegicus (OPRD_RAT)
G-protein activation	Rattus norvegicus (OPRM_RAT)
Opioid Signalling	Rattus norvegicus (OPRM_RAT)
Peptide ligand-binding receptors	Rattus norvegicus (OPRD_RAT) Mus musculus (OPRD_MOUSE)