| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 18th, 2005 | 28 | No |
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 2.14 | -2.06 | -11.69 | 3 | 6 | 0 | 104 | 390.476 | 3 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| KPCA-3-E | Protein Kinase C Alpha (cluster #3 Of 6), Eukaryotic | Eukaryotes | 13 | 0.39 | Binding ≤ 10μM |
| KPCB-1-E | Protein Kinase C Beta (cluster #1 Of 4), Eukaryotic | Eukaryotes | 13 | 0.39 | Binding ≤ 10μM |
| KPCD-2-E | Protein Kinase C Delta (cluster #2 Of 4), Eukaryotic | Eukaryotes | 210 | 0.33 | Binding ≤ 10μM |
| KPCD1-3-E | Protein Kinase C Mu (cluster #3 Of 3), Eukaryotic | Eukaryotes | 210 | 0.33 | Binding ≤ 10μM |
| KPCD3-3-E | Protein Kinase C Nu (cluster #3 Of 3), Eukaryotic | Eukaryotes | 210 | 0.33 | Binding ≤ 10μM |
| KPCE-2-E | Protein Kinase C Epsilon (cluster #2 Of 5), Eukaryotic | Eukaryotes | 210 | 0.33 | Binding ≤ 10μM |
| KPCG-1-E | Protein Kinase C Gamma (cluster #1 Of 4), Eukaryotic | Eukaryotes | 13 | 0.39 | Binding ≤ 10μM |
| KPCL-1-E | Protein Kinase C Eta (cluster #1 Of 4), Eukaryotic | Eukaryotes | 210 | 0.33 | Binding ≤ 10μM |
| KPCT-2-E | Protein Kinase C Theta (cluster #2 Of 3), Eukaryotic | Eukaryotes | 210 | 0.33 | Binding ≤ 10μM |
| Z50607-8-O | Human Immunodeficiency Virus 1 (cluster #8 Of 10), Other | Other | 132 | 0.34 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| KPCA_MOUSE | P20444 | Protein Kinase C Alpha, Mouse | 12.5 | 0.40 | Binding ≤ 1μM |
| KPCA_HUMAN | P17252 | Protein Kinase C Alpha, Human | 190 | 0.34 | Binding ≤ 1μM |
| KPCA_BOVIN | P04409 | Protein Kinase C Alpha, Bovin | 4.8 | 0.42 | Binding ≤ 1μM |
| KPCB_HUMAN | P05771 | Protein Kinase C Beta, Human | 190 | 0.34 | Binding ≤ 1μM |
| KPCB_MOUSE | P68404 | Protein Kinase C Beta, Mouse | 12.5 | 0.40 | Binding ≤ 1μM |
| KPCD_HUMAN | Q05655 | Protein Kinase C Delta, Human | 190 | 0.34 | Binding ≤ 1μM |
| KPCD_MOUSE | P28867 | Protein Kinase C Delta, Mouse | 12.5 | 0.40 | Binding ≤ 1μM |
| KPCE_HUMAN | Q02156 | Protein Kinase C Epsilon, Human | 190 | 0.34 | Binding ≤ 1μM |
| KPCL_HUMAN | P24723 | Protein Kinase C Eta, Human | 190 | 0.34 | Binding ≤ 1μM |
| KPCL_MOUSE | P23298 | Protein Kinase C Eta, Mouse | 12.5 | 0.40 | Binding ≤ 1μM |
| KPCG_HUMAN | P05129 | Protein Kinase C Gamma, Human | 190 | 0.34 | Binding ≤ 1μM |
| KPCG_MOUSE | P63318 | Protein Kinase C Gamma, Mouse | 12.5 | 0.40 | Binding ≤ 1μM |
| KPCD1_HUMAN | Q15139 | Protein Kinase C Mu, Human | 190 | 0.34 | Binding ≤ 1μM |
| KPCD3_HUMAN | O94806 | Protein Kinase C Nu, Human | 190 | 0.34 | Binding ≤ 1μM |
| KPCT_HUMAN | Q04759 | Protein Kinase C Theta, Human | 190 | 0.34 | Binding ≤ 1μM |
| KPCA_MOUSE | P20444 | Protein Kinase C Alpha, Mouse | 12.5 | 0.40 | Binding ≤ 10μM |
| KPCA_HUMAN | P17252 | Protein Kinase C Alpha, Human | 190 | 0.34 | Binding ≤ 10μM |
| KPCA_BOVIN | P04409 | Protein Kinase C Alpha, Bovin | 4.8 | 0.42 | Binding ≤ 10μM |
| KPCB_MOUSE | P68404 | Protein Kinase C Beta, Mouse | 12.5 | 0.40 | Binding ≤ 10μM |
| KPCB_HUMAN | P05771 | Protein Kinase C Beta, Human | 190 | 0.34 | Binding ≤ 10μM |
| KPCD_MOUSE | P28867 | Protein Kinase C Delta, Mouse | 12.5 | 0.40 | Binding ≤ 10μM |
| KPCD_HUMAN | Q05655 | Protein Kinase C Delta, Human | 190 | 0.34 | Binding ≤ 10μM |
| KPCE_HUMAN | Q02156 | Protein Kinase C Epsilon, Human | 190 | 0.34 | Binding ≤ 10μM |
| KPCL_HUMAN | P24723 | Protein Kinase C Eta, Human | 190 | 0.34 | Binding ≤ 10μM |
| KPCL_MOUSE | P23298 | Protein Kinase C Eta, Mouse | 12.5 | 0.40 | Binding ≤ 10μM |
| KPCG_MOUSE | P63318 | Protein Kinase C Gamma, Mouse | 12.5 | 0.40 | Binding ≤ 10μM |
| KPCG_HUMAN | P05129 | Protein Kinase C Gamma, Human | 190 | 0.34 | Binding ≤ 10μM |
| KPCD1_HUMAN | Q15139 | Protein Kinase C Mu, Human | 190 | 0.34 | Binding ≤ 10μM |
| KPCD3_HUMAN | O94806 | Protein Kinase C Nu, Human | 190 | 0.34 | Binding ≤ 10μM |
| KPCT_HUMAN | Q04759 | Protein Kinase C Theta, Human | 190 | 0.34 | Binding ≤ 10μM |
| Z50607 | Z50607 | Human Immunodeficiency Virus 1 | 0.1 | 0.50 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Acetylcholine regulates insulin secretion | |
| Activation of NF-kappaB in B cells | |
| Apoptotic cleavage of cellular proteins | |
| Ca2+ pathway | |
| Calmodulin induced events | |
| DAG and IP3 signaling | |
| Depolymerisation of the Nuclear Lamina | |
| Disinhibition of SNARE formation | |
| Downstream TCR signaling | |
| Effects of PIP2 hydrolysis | |
| EGFR Transactivation by Gastrin | |
| FCERI mediated NF-kB activation | |
| G alpha (z) signalling events | |
| HuR stabilizes mRNA | |
| Inactivation, recovery and regulation of the phototransduction cascade | |
| Interferon gamma signaling | |
| Netrin-1 signaling | |
| Regulation of KIT signaling | |
| Response to elevated platelet cytosolic Ca2+ | |
| Role of phospholipids in phagocytosis | |
| Signaling by SCF-KIT | |
| Sphingolipid de novo biosynthesis | |
| Syndecan interactions | |
| Trafficking of GluR2-containing AMPA receptors | |
| VEGFR2 mediated cell proliferation | |
| WNT5A-dependent internalization of FZD4 |
