| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| April 14th, 2010 | 23 | No |
Popular Name: DNC014808 DNC014808
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 1.76 | -1.69 | -57.98 | 5 | 9 | -1 | 168 | 321.217 | 4 | ↓ |
| Hi High (pH 8-9.5) | 1.76 | -0.62 | -112.04 | 4 | 9 | -2 | 170 | 320.209 | 4 | ↓ |
| Hi High (pH 8-9.5) | 1.76 | -0.65 | -119.04 | 4 | 9 | -2 | 170 | 320.209 | 4 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| DPOLA-1-E | DNA Polymerase Alpha Subunit (cluster #1 Of 2), Eukaryotic | Eukaryotes | 830 | 0.37 | Binding ≤ 10μM |
| DPOLB-3-E | DNA Polymerase Beta (cluster #3 Of 3), Eukaryotic | Eukaryotes | 390 | 0.39 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| DPOLA_HUMAN | P09884 | DNA Polymerase Alpha Subunit, Human | 830 | 0.37 | Binding ≤ 1μM |
| DPOLB_HUMAN | P06746 | DNA Polymerase Beta, Human | 390 | 0.39 | Binding ≤ 1μM |
| DPOLA_HUMAN | P09884 | DNA Polymerase Alpha Subunit, Human | 830 | 0.37 | Binding ≤ 10μM |
| DPOLB_HUMAN | P06746 | DNA Polymerase Beta, Human | 390 | 0.39 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activation of the pre-replicative complex | |
| Base-free sugar-phosphate removal via the single-nucleotide replacement pathway | |
| DNA replication initiation | |
| E2F mediated regulation of DNA replication | |
| G1/S-Specific Transcription | |
| Inhibition of replication initiation of damaged DNA by RB1/E2F1 | |
| Leading Strand Synthesis | |
| Polymerase switching | |
| Polymerase switching on the C-strand of the telomere | |
| Processive synthesis on the lagging strand | |
| Removal of DNA patch containing abasic residue | |
| Removal of the Flap Intermediate | |
| Resolution of AP sites via the single-nucleotide replacement pathway | |
| Telomere C-strand synthesis initiation |
